2021 College Football Week 2 Preview, Odds and Picks

There were a handful of wild upsets around during Week 1 of the 2021 College Football season, including a few Power 5 schools being stunned by FCS programs. Will things even out in Week 2? Here’s a look at some of the bigger matchups – sans Oregon vs. Ohio State, which we will preview individually.

Be sure to check out the latest 2021 College Football odds and lines at our online Bitcoin sportsbook before placing your bets this season!

Top 2021 College Football Week 2 Preseason Games to Bet On

Texas A&M Aggies at Colorado Buffaloes

  • When: Saturday, September 11th, 2:30pm ET
  • Where: Empower Field at Mile High, Denver, Colorado
  • 2021 College Football Week 2 Odds: Texas A&M Aggies -17

Texas A&M was ranked No. 6 in Week 1 and might move up a spot in the new polls. The Aggies opened with an easy 41-10 win over MAC school Kent State. After a tightly contested first half, the Aggies outscored the Golden Flashes 31-7 after the intermission, including 17-0 in the third quarter.

Texas A&M had 595 total yards of offense, the most since Lamar in 2019. A&M’s Devone Achane, Isaiah Spiller and Ainias Smith gave the Aggies two 100-yard rushers and one 100-yard receivers in a game for the first time since September 23, 2017 when Kellen Mond (109 rush), Keith Ford (102 rush) and Christian Kirk (110 receiving) did the deed against Arkansas. Haynes King went 21-for-33 passing for 292 yards and two touchdowns in his first career start at QB.

The Aggies have won nine straight games, which ties them for the second longest active win streak in the FBS with Oklahoma and behind Alabama. This is also the most consecutive wins since the 1998 season (10).

Colorado beat Northern Colorado 35-7. The Buffs finished with 383 yards total offense, including an overwhelming 281-20 edge on the ground as four different CU running backs found the end zone. The last time four different running backs scored in a game was on Sept. 26, 2015. CU freshman quarterback Brendon Lewis completed 10 of 15 attempts for 102 yards and a touchdown in his starting debut, and he also ran for 44 yards.

2021 College Football Week 2 Pick: Texas A&M

Washington Huskies at Michigan Wolverines

  • When: Saturday, September 11th, 7:00pm ET
  • Where: Michigan Stadium, Ann Arbor, Michigan
  • 2021 College Football Week 2 Odds: Michigan Wolverines -4

Michigan routed Western Michigan 47-14 in Week 1 but it was costly as top receiver and punt returner Ronnie Bell suffered a season-ending injury.

The Wolverines had up 334 yards on the ground and had three running backs with at least 70 yards rushing and a touchdown apiece, headlined by sophomore Blake Corum, who recorded career highs with 14 carries and 111 rushing yards, and scored a pair of touchdowns — one rushing and one receiving. Junior quarterback Cade McNamara completed nine of 11 passes for 136 yards and two scores.

Bell led the receiving corps with 76 yards and a touchdown – on one play — before exiting with injury in the second quarter with a knee injury while returning a punt. His season-ending diagnosis was confirmed Monday. Bell had been the team’s leading receiver each of the last two years. He had 48 catches for 758 yards and one touchdown in 2019 and caught 26 passes for 401 yards and one touchdown during the shortened 2020 season. Cornelius Johnson was second on the team in receiving yards in 2020, with 254 yards and three touchdowns and likely will take over as the featured receiver.

Washington was ranked No. 20 entering Week 1 but will fall out of the Top 25 after suffering one of the worst losses in school history, 13-7 at home to FCS school Montana. It was the first FCS team to beat a ranked FBS team since North Dakota State won at No. 13 Iowa 23-21 early in the 2016 season, and the fifth time it has happened since Appalachian State’s famous upset of No. 5 Michigan in 2007. It was the fewest points scored by the Huskies since Oct. 14, 2017 in a 13-7 loss at Arizona State. It was the fewest at home since a 31-0 shutout vs. Stanford on Oct. 30, 2010. Pick: Michigan.

2021 College Football Week 2 Pick: Michigan

Toledo Rockets at Notre Dame Fighting Irish

  • When: Saturday, September 11th, 1:30pm ET
  • Where: Notre Dame Stadium, Notre Dame, Indiana
  • 2021 College Football Week 2 Odds: Notre Dame Fighting Irish -16

The Irish could move up from No. 9 after their wild 41-38 OT win at Florida State on Sunday – this could be a trap game for Notre Dame on a short week and that exhausting victory. It was Notre Dame’s first overtime road win. The overtime rule changes were introduced in 1996. Jonathan Doerer hit a 41-yard field goal to clinch the game in the first overtime after Florida State missed their field goal attempt.

Wisconsin transfer Jack Coan threw for 366 yards, the most by a Notre Dame QB in a season opener. The previous record was 346 yards by Tommy Rees in 2013. Coan is the first Irish QB to have 300 yards and four touchdowns since Jimmy Clausen in 2009. The Irish won their 33rd consecutive game against an unranked opponent, a streak that dates back to the 2016 season.

Toledo is a good MAC program that beat Norfolk State 49-10 in Week 1. Toledo’s special teams blocked two punts that were returned for touchdowns, and also recovered a fumble on a kickoff. It was the first time in school history that Toledo scored on two blocked punts.

Toledo is 9-17 all-time vs. teams in the Top 25. Its last win against a Top 25 team was vs. No. 24 Temple in the 2015 Boca Raton Bowl, Jason Candle’s very first game as the Rockets’ head coach.

2021 College Football Week 1 Pick: Toledo

READ MORE: 2021 NFL Week 1 Preview, Odds and Picks

Check out our latest sports betting guides for the 2021 College Football season. Stay tuned for more Football previews and articles and don’t forget to check out the latest Football betting odds at our online Bitcoin sportsbook.

*All odds stated are subject to change without prior notice.