The NFL Divisional Playoffs are set. All four seeds in the American Football Conference advanced. On Saturday, the 4-Cincinnati Bengals head to Nissan Stadium in Nashville to take on the 1-Tennessee Titans. Then on Sunday, the 2-Kansas City Chiefs host the 3-Buffalo Bills at Arrowhead Stadium. Check out against the spread odds, analysis, and a free pick for this weekend’s AFC Divisional Round games.

2022 AFC Divisional Playoff Betting Prediction

READ MORE: 2022 NFC Divisional Round Betting Prediction

Cincinnati Bengals vs. Tennessee Titans

• When: Saturday, Jan. 22. 4:30pm ET
• NFL Odds: Tennessee Titans -3.5

Cincinnati played great defense to beat the Las Vegas Raiders 26-19 in their first playoff victory since 1991. The key for Cincinnati, like always, will be how well Joe Burrow plays. If Burrow lights it up, forget it. The Stripes should challenge the Titans. But that may not happen because of key injuries to defensive tackle Larry Ogunjobi, who Cincy placed on IR, and end Trey Hendrickson.

Hendrickson suffered a concussion in the victory over the Raiders. If Hendrickson can’t go, Ryan Tannehill could have more time than expected to find open receivers. Tennessee is the type of team that thrives when they mustn’t throw the football. The Titans get Derrick Henry back, which means they’ve got a serious 1-2 punch at running back. While Henry was on the bench due to an injury, D’Onta Foreman quietly rushed for 566 yards and a 4.3 per rush average.

Knowing coach Mike Vrabel, he might instruct his staff to use both Foreman and Henry in the backfield at the same time. Doing so should open the middle of the field for A.J. Brown, one of the most talented wide receivers in the league.

All-in-all, the Titans are the better team. This betting line doesn’t do Tennessee justice. Burrow is fantastic, but the right side of the offensive line should put Joe in danger from the outset. Titans win and cover.

AFC Divisional Round Pick: Tennessee Titans

Buffalo Bills vs. Kansas City Chiefs

• When: Sunday, Jan. 23. 6:30pm ET.
• NFL Odds: Kansas City Chiefs -2.5

These two faced off in Week 5 with the Bills providing a stunning 38-25 win as a, wait for it . . . +2.5 underdog. Oddsmakers apparently don’t have much of an opinion because they’ve copied themselves from the line they set in the first game.

In any case, a repeat, at least in the sense of strategy, could be in order. The Bills will use Allen’s legs to temper Kansas City’s defense. If Allen is successful, it’s difficult seeing pressure not landing on Patrick Mahomes and KC’s offense.

That wouldn’t be a bad thing. Once Mahomes and the offense got it going, they decimated a decent Pittsburgh defense. The Chiefs’ offensive line was terrific at picking up Pittsburgh’s blitz. More importantly, Jerrick McKinnon, the former Minnesota Viking, was a revelation. McKinnon had 8 catches for 81 yards and a touchdown. He adds another element to an already scary offense.

Both teams have good defenses. If you think this goes under, though, take another look. The Bills’ and Chiefs’ send skill players to the field that both defenses are going to have trouble covering.

Kansas City has the slight edge due to home field, but the betting line should be even. Buffalo linebacker Tremaine Edmunds is as good as there is at covering tight-ends. He’ll do a decent enough job on Travis Kelce to keep Mahomes’ favorite target from burning the Bills.

Not only that, but the Bills used their tight-end, Dawson Knox, to great effect against the New England Patriots. This game could come down to who has the ball last, so as long as Buffalo is more than +110 on the moneyline, they’re the play. Right now, the Bills are at +116, which means Allen and his mates are an overlay.

AFC Divisional Round Pick: Buffalo Bills moneyline

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*All odds stated are subject to change without prior notice.