2022 College Football Week 10 Odds, Overview & Picks

By Hank Blaine

The first College Football Playoff Rankings of the season landed earlier in the week, which makes Saturday’s top games super important. The three most significant are Alabama against rival LSU, top CFP ranked Tennessee on the road against Georgia and fourth-ranked Clemson versus Notre Dame in South Bend.

Before everything else, NitroBetting arms you with everything you need to kick things off on a positive note. Below, we provide event details, team and player statistics, and the latest College Football odds. More than that, we go the extra mile and share timely betting trends and predictions that help you secure the best picks. Check out for more sports betting odds and lines, exclusively at our online BTC sportsbook.

Top 2022 College Football Week 10 Games to Bet

Texas Tech Red Raiders vs. TCU Horned Frogs

  • When: Saturday, November 5th, 2022. 12:00pm EST.
  • Where: Amon G. Carter Stadium, Fort Worth, TX
  • College Football Odds: Texas Tech (+8) // TCU (-8)

8-0 TCU believes they’re being disrespected. The Horned Frogs have a similar record to Tennessee, Georgia, Michigan, Ohio State, and Clemson.

Bama, who lost to Tennessee, ranks a spot ahead of the Frogs. All 6-1-1 ATS Texas Christian can do to change the selection committee’s mind this weekend is dominate an overmatched Texas Tech team.

2022 College Football Week 10 Pick: TCU

Texas Longhorns vs. Kansas State Wildcats

  • When: Saturday, November 5th, 2022. 7:00pm EST.
  • Where: Bill Snyder Family Stadium, Manhattan, KS
  • College Football Odds: Texas (-2.5) // Kansas State (+2.5)

The love for the Longhorns knows no bounds. The last time Texas faced a top Big 12 rival on the road, Oklahoma State rallied to beat the Horns.

Kansas State dominated Oklahoma State 48-0 in their last. But Wildcats quarterback Adrian Martinez, who it feels like is in his tenth season of eligibility, is banged up and questionable to play. The Horns should cover.

2022 College Football Week 10 Pick: Texas

Baylor Bears vs. Oklahoma Sooners

  • When: Saturday, November 5th, 2022. 3:00pm EST.
  • Where: Memorial Stadium, Norman, OK
  • College Football Odds: Baylor (+3.5) // Oklahoma (-3.5)

After 2 straight losses, 1 of which they had no business losing, the Bears have won their last 2 games. Both wins were also cover victories, 35-23 against Kansas and 45-17 on the road versus Texas Tech.

Oklahoma beat Iowa State 27-13 in their last. The Sooners are 3-5 against the spread. Not only that but the Bears are 9-2 ATS in the last 11 meetings in Oklahoma. Don’t be surprised if Baylor nabs the money line victory.

2022 College Football Week 10 Pick: Baylor

Tennessee Volunteers vs. Georgia Bulldogs

  • When: Saturday, November 5th, 2022. 3:30pm EST.
  • Where: Sanford Stadium, Athens, GA
  • College Football Odds: Tennessee (+3.5) // Georgia (-3.5)

The CFP Selection Committee believes Tennessee is the best team in the nation. So it’s interesting that Georgia is such a huge spread line chalk versus Hendon Hooker and the Vols.

The defending champs, that’s Georgia, are good. But outside of the 49-3 win against Oregon in their first game of the season, UGA hasn’t beaten a team that comes close to Tennessee.

The Volunteers boast the nation’s top-ranked offense in points per and yards per. Volunteers +9 is a solid play.

2022 College Football Week 10 Pick: Tennessee

Alabama Crimson Tide vs. LSU Tigers

  • When: Saturday, November 5th, 2022. 7:00pm EST.
  • Where: Tiger Stadium, Baton Rouge, LA
  • College Football Odds: Alabama (-13.5) // LSU (+13.5)

Since the loss to Tennessee, the Tigers from Baton Rouge have beaten Florida 45-35 and dusted then undefeated Ole Miss 45-20. A win over Bama would put LSU on track to win the SEC West Division.

Ah, but a victory doesn’t seem possible. Bama is too good. Even a cover win doesn’t seem probable because Bama is 4-0 ATS in the last 4 meetings in LSU.

2022 College Football Week 10 Pick: Alabama

Clemson Tigers vs. Notre Dame Fighting Irish

  • When: Saturday, November 5th, 2022. 7:30pm EST.
  • Where: Notre Dame Stadium, Notre Dame, IN
  • College Football Odds: Clemson (-3.5) // Notre Dame (+3.5)

The College Football Playoff Committee believes in Dabo Swinney and the Clemson Tigers. Swinney had hoped he’d be playing against an undefeated Notre Dame squad on Saturday.

Instead, Clemson faces a 5-3 Irish team. But although only 5-3 SU, the Fighting Irish head into this with momentum. Notre Dame beat Syracuse 41-24 in their last. On their field, ND should cover.

2022 College Football Week 10 Pick: Notre Dame

Wake Forest Demon Deacons vs. NC State Wolfpack

  • When: Saturday, November 5th, 2022. 8:00pm EST.
  • Where: Carter-Finley Stadium, Raleigh, NC
  • College Football Odds: Wake Forest (-4) // NC State (+4)

With Sam Hartman under center, Wake Forest has a huge edge at quarterback. NC State starter Dennis Leary got hurt in the victory over Florida State a few weeks back.

Since then, the Wolfpack have dropped a game versus Syracuse and barely beat Virginia Tech 22-21 as a -12 chalk. NC State has lost 5 straight against the spread. The odds make Wake more than playable.

2022 College Football Week 10 Pick: Wake Forest

UCLA Bruins vs. Arizona State Sun Devils

  • When: Saturday, November 5th, 2022. 8:00pm EST.
  • Where: Carter-Finley Stadium, Raleigh, NC
  • College Football Odds: UCLA (-11) // NC State (+11)

UCLA is 4-1 ATS in their last 5. The Bruins average over 500 yards and close to 40 points per game. ASU allows over 400 yards and close to 29 points per on average.

The trends point to a UCLA cover victory. The Bruins are 10-1 ATS in their last 11 versus conference opponents. Bruins roll.

2022 College Football Week 10 Pick: UCLA

Where to Bet On College Football with Bitcoin

College Football odds are available all year round here at Nitrobetting. Create a Nitrobetting account now to win tons of Bitcoin from the 2022 College Football offseason with our up-to-date NCAAF futures odds, as well as our special Bitcoin Squares and Picks contests throughout the upcoming regular season!

Check out our latest sports betting guides for the 2022 College Football season. Stay tuned for more football previews and articles and don’t forget to check out the latest NCAAF betting odds at our online Bitcoin sportsbook.

*All stated odds are subject to change without prior notice.

READ MORE: 2022 College Football Week 11 Odds, Overview & Picks

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