2022 College Football Week 8 Odds, Overview & Picks

By Hank Blaine

We’ve reached about the halfway point of the 2022 college football regular season and for the first time there’s a team not named Alabama or Georgia favored to win the national title. That would be unbeaten Ohio State, which is actually off this week. Here are two marquee Week 7 matchups.

Before everything else, NitroBetting arms you with everything you need to kick things off on a positive note. Below, we provide event details, team and player statistics, and the latest NCAAF odds. More than that, we go the extra mile and share timely betting trends and predictions that help you secure the best picks. Check out for more sports betting odds and lines, exclusively at our online BTC sportsbook.

Top 2022 College Football Week 8 Games to Bet

Syracuse Orange vs. Clemson Tigers

  • When: Saturday, October 22nd, 2022. 12:00pm EST.
  • Where: Memorial Stadium, Clemson, SC
  • College Football Odds: Syracuse (+13.5) // Clemson (-13.5)

In their last 3 games, Clemson has made a statement. The Tigers beat and covered the spread versus NC State, Boston College, and Florida State.

Syracuse has also rocked it. The difference is that the Orange is 6-0 straight up and 5-1 against the spread. Clemson should win, but laying -13.5 is tough. Syracuse takes the ATS victory.

2022 College Football Week 8 Pick: Syracuse

Texas Longhorns vs. Oklahoma State Cowboys

  • When: Saturday, October 22nd, 2022. 3:30pm EST.
  • Where: Boone Pickens Stadium, Stillwater, OK
  • College Football Odds: Texas (-6.5) // Oklahoma State (+6.5)

In what world are the Texas Longhorns -6.5 road favorites versus Oklahoma State? Yes, there is a trend that says the Longhorns win and cover, but OSU is 5-1 straight up and 4-2 ATS. The Pokes have a big edge because this happens at Boone Pickens Stadium. The Horns will make it close, but giving up 6.5 on the road makes zero sense.

2022 College Football Week 8 Pick: Oklahoma State

Ole Miss Rebels vs. LSU Tigers

  • When: Saturday, October 22nd, 2022. 3:30pm EST.
  • Where: Tiger Stadium, Baton Rouge, LA
  • College Football Odds: Ole Miss (+2.5) // LSU (-2.5)

Slowly but surely, LSU is turning into a solid team. But although the Tigers have played well in recent contests, they’re up against it versus one of the best teams in the SEC. Like Tennessee and Georgia, Ole Miss is undefeated. The Rebels average close to 41 points per game. The spread line makes Mississippi an overlay.

2022 College Football Week 8 Pick: Ole Miss

UCLA Bruins vs. Oregon Ducks

  • When: Saturday, October 22nd, 2022. 3:30pm EST.
  • Where: Autzen Stadium, Eugene, OR
  • College Football Odds: UCLA (+2.5) // Oregon (-2.5)

Who would have thought that at this point of the season Oregon and UCLA would be ranked in the top ten? UCLA surprised big time in their last when upsetting Utah 42-32.

Chip Kelly’s squad is playing great football. Since an embarrassing first game loss to Georgia, Oregon has won 5 straight. This happens in Autzen. So there is a reason the Ducks are the favorite. But -6 points are too many to give to a Bruins squad that is good enough to win straight up.

2022 College Football Week 8 Pick: UCLA

Mississippi State Bulldogs vs. Alabama Crimson Tide

  • When: Saturday, October 22nd, 2022. 7:00pm EST.
  • Where: Bryant-Denny Stadium, Tuscaloosa, AL
  • College Football Odds: Mississippi State (+21) // Alabama (-21)

Bama’s loss to Tennessee last Saturday makes sense. Tennessee is a good team and the game happened on their field. Mississippi State is a good team. But this Saturday’s game happens in Tuscaloosa. Bryce Young should carve up the Bulldogs’ D while Miss State’s offense will struggle versus Will Anderson, Dallas Turner, and Bama’s defensive line. The Tide covers.

2022 College Football Week 8 Pick: Alabama

Mississippi State Bulldogs vs. Alabama Crimson Tide

  • When: Saturday, October 22nd, 2022. 7:00pm EST.
  • Where: Bryant-Denny Stadium, Tuscaloosa, AL
  • College Football Odds: Mississippi State (+21) // Alabama (-21)

Bama’s loss to Tennessee last Saturday makes sense. Tennessee is a good team and the game happened on their field. Mississippi State is a good team. But this Saturday’s game happens in Tuscaloosa. Bryce Young should carve up the Bulldogs’ D while Miss State’s offense will struggle versus Will Anderson, Dallas Turner, and Bama’s defensive line. The Tide covers.

2022 College Football Week 8 Pick: Alabama

Minnesota Golden Gophers vs. Penn State Nittany Lions

  • When: Saturday, October 22nd, 2022. 7:30pm EST.
  • Where: Beaver Stadium, University Park, PA
  • College Football Odds: Minnesota (+4) // Penn State (-4)

Since starting the season going 4-0, Minnesota has since fallen apart, losing 2 straight to Purdue and Illinois. The problem with backing the Golden Gophers is that Minny hasn’t even competed in their last couple of games.

Penn State lost their first game of the season last week but the loss happened against CFP contender Michigan and it happened on the road. The Lions bounce back with a win and cover.

2022 College Football Week 8 Pick: Penn State

Pittsburgh Panthers vs. Louisville Cardinals

  • When: Saturday, October 22nd, 2022. 8:00pm EST.
  • Where: Cardinal Stadium, Louisville, KY
  • College Football Odds: Pittsburgh (+2.5) // Louisville (-2.5)

4-2 Pittsburgh heads to 3-3 Louisville in a key matchup on Saturday. The Panthers have won 3-of-4. Pitt is 2-4 against the spread this season, though. That’s not a great sign.

A good sign for Louisville is Malik Cunningham’s status. The Cardinals starting QB is listed as probable. Malik should play, which means Louisville wins and covers.

2022 College Football Week 8 Pick: Louisville

Kansas State Wildcats vs. TCU Horned Frogs

  • When: Saturday, October 22nd, 2022. 8:00pm EST.
  • Where: Amon G. Carter Stadium, Fort Worth, TX
  • College Football Odds: Pittsburgh (+2.5) // Louisville (-2.5)

5-1 Kansas State is also 4-1-1 against the spread. The road underdog in this averages 28.7 points per game, but proved in their last, a 10-9 win against Iowa State, that they could secure a victory with their defense.

TCU doesn’t play defense. Not only that, but the Horned Frogs head into this after a couple of tough wins against Kansas and Oklahoma State. The Frogs could bounce. K-State is the play.

2022 College Football Week 8 Pick: Kansas State

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*All stated odds are subject to change without prior notice.

READ MORE: 2022 College Football Week 9 Odds, Overview & Picks