The closer we get to the NFL Playoffs, the more important each NFL game becomes. NFL Week 15 is no exception. Things start with a bang on Thursday night when the LA Rams head to Levi’s Stadium to take on the rival San Francisco 49ers. On Sunday, Cincinnati hopes to keep their playoff hopes alive against the Titans, and the Denver Broncos hope to keep their playoff path open in a home game versus the Colts. See below for NFL Week 15 odds, analysis, and picks for six of this week’s best NFL betting picks.

Top Picks to Bet on NFL Week 15

Week 15 Power Rankings pic.twitter.com/e9BO5BCm7Q

— NFL on FOX Podcast (@NFLonFOXPod) December 10, 2024

LA Rams vs. San Francisco 49ers

• When: Thursday, December 12th, 2024. 8:15pm EST
• NFL Week 15 Odds: Rams (+2.5) // 49ers (-2.5)

Going moneyline on the underdog Rams makes the most sense. Mathew Stafford, Puka Nucua, Kyren Williams and Cooper Kupp were hot against the Buffalo Bills in NFL Week 14 when ending the Bills’ 7-game winning streak.

The Rams scored 44 points versus the Bills’ D. The 49ers’ defense is healthy, but the offense doesn’t have the players to keep up with Staff and his buds. Rams win in what will be a shootout.

Cincinnati Bengals vs. Tennessee Titans

• When: Sunday, December 15th, 2024. 1:00pm EST
• NFL Week 15 Odds: Bengals (-5) // Titans (+5)

Joe Burrow and Ja’Marr Chase are blitzing defense. The Titans’ offense faces a Bengals’ D they will score points against, but it won’t be enough.

Tennessee’s problem is that the defense folds when it faces strong offenses. Jared Goff and the Lions scored 52, Jayden Daniels and the Commanders scored 42, and Josh Allen and Buffalo scored 34. Burrow, Chase, and the Bengals should drop 35 to 40 or even more when covering the -5.

Miami Dolphins vs. Houston Texans

• When: Sunday, December 15th, 2024. 1:00pm EST
• NFL Week 15 Odds: Dolphins (+3) // Texans (-3)

Houston won their last game, but in recent week’s the Texans haven’t looked close to being the feared team that they looked like earlier in the season. CJ Stroud and his mates have gone 2-3 in their last 5.

The 32-27 loss to the Titans in NFL Week 13 wasn’t good. Tua Tagovailoa and Miami have won 3-of-4 with the loss coming on Thanksgiving versus the Packers at Lambeau. The Fins win straight up.

New England Patriots vs. Arizona Cardinals

• When: Sunday, December 15th, 2024. 4:25pm EST
• NFL Week 15 Odds: TBA

The Patriots catch the Cardinals at the right time. Arizona looked like the best team in the NFC West during a 4-game winning streak, but in their last 3, the Cards have fallen apart.

Arizona has lost to the Seahawks twice and the Vikings in their last 3. The home loss to Seattle in a 30-18 game in NFL Week 14 was the worst loss of the bunch.

New England isn’t a good football team, but Drake Maye has gotten better each week. Also, the Pats hung with the Colts in a 25-24 loss in their last. Give New England the nod to cover the spread.

LA Chargers vs. Tampa Bay Buccaneers

• When: Sunday, December 15th, 2024. 4:25pm EST
• NFL Week 15 Odds: Chargers (-3) // Buccaneers (+3)

Baker Mayfield is having a good season, but on Sunday the Bucs face one of the better teams in the AFC on the road. The Bolts have gone 8-5 so far in Jim Harbaugh’s first season as head coach.

Although LAC is 1-2 straight up in their last 3, the losses came against the Ravens and the Chiefs. The Chargers’ boast the better defense, while Justin Herbert should have no trouble torching a Bucs’ defense that gave up 41 points to the Ravens, over 30 points to the Falcons twice, and 30 points to Kansas City this season. Bolts cover.

Denver Broncos vs. Indianapolis Colts

• When: Sunday, December 15th, 2024. 4:25pm EST
• NFL Week 15 Odds: Broncos (+2.5) // Colts (-2.5)

Beware a Sean Payton coached team after a bye. That’s the situation in Denver versus Colts. Before the bye, the Broncos were solidifying their position as this season’s Cinderella with wins over the Falcons, Raiders, and Browns.

Indianapolis is going to have a tough time dealing with Bo Nix, who is making a late season push to challenge Jayden Daniels for the NFL Offensive Rookie of the Year Award. The Denver D is going to be all over Colts’ starting quarterback Anthony Richardson. Broncos win by 6 or more.

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