2025 Champions League Quarterfinals Leg 2 Betting Preview

The 2025 Champions League Quarterfinals Leg 2 matches are here. On Tuesday, Paris Saint-Germain, a favorite to lift the CL trophy, heads to England to take on Premier League squad Aston Villa, and Barcelona heads to Germany to battle Bundesliga team Dortmund. Then, on Wednesday, Inter Milan hosts Bayern Munich, a slight favorite, and Real Madrid is the heavy chalk versus Arsenal. Which teams notch their tickets to the Champions League Semifinals? Check out the 2025 Champions League odds, analysis, and picks for this week’s leg 2 quarterfinal matches.

2025 Champions League Quarterfinals Leg 2 Game Previews

We go again #UCL pic.twitter.com/xtvRDKLcfw

— UEFA Champions League (@ChampionsLeague) April 14, 2025

Aston Villa vs. Paris Saint-Germain

• When
• 2025 Champions League Odds Aston Villa (+220) / PSG (+115) / Draw (+270)

PSG can coast in the second leg. Paris Saint-Germain has built a 3-1 aggregate lead after dominating Aston in the first leg. It will be nearly impossible for Aston Villa to overcome a 2-goal deficit versus a motivated Paris Saint-Germain side that wants to prove it can win the Champions League without Kylian Mbappe or Neymar.

The chemistry on this PSG team makes the Ligue 1 power more dangerous than ever. Aston could score a 1-goal victory, especially with Marcus Rashford finding new life in an Aston Villa kit. Still, the best play is the draw because PSG isn’t going to push the pace, fearing an injury to one of their players, and they are a great defensive team. 0-0 or 1-1 is the likeliest outcome.

2025 Champions League Quarterfinals Leg 2 Pick: Draw

Borussia Dortmund vs. Barcelona

• When
• 2025 Champions League OddsBorussia Dortmund (+250) / Barcelona (-120) / Draw (+340)

This year, Barcelona means business. The House that Messi built has put their past behind them by not only working into first place and a likely La Liga trophy win, but also playing like the best squad left in the Champions League.

It doesn’t matter who starts up front for Barcelona. Lewandowski, young Lamine Yamal, even younger Toni Fernandez, Raphinha, Ansu Fati, and Pau Victor are all capable. The great Dani Olmo and Frenkie de Jong take care of the middle of the field, and the defense is solid.

Dortmund may not score a goal. So even though Barcelona has the 4 goals lead, we shouldn’t look past the La Liga squad in this. Barca wins 1-0 or 2-0 at a decent payout.

2025 Champions League Quarterfinals Leg 2 Pick: Barcelona

Inter Milan vs. Bayern Munich

• When
• 2025 Champions League OddsInter Milan (+165) / Bayern Munich (+145) / Draw (+270)

The thinking is that since Bayern is down 2-1 on the aggregate, the team from Munich steps it up and beats Inter. Ah, but this happens at the Guisseppe Meazza, where Inter is almost impossible to beat.

Besides that, man-to-man, how much better is Bayern than Inter Milan? Yes, Bayern has the ageless Thomas Mueller, Kingsley Coman, Leroy Sane, and striker extraordinaire Harry Kane. But Inter boasts Lautaro Martinez, who scored the first goal in the first leg.

Martinez plays better at home, which makes Inter an exciting prospect at +165. Knowing how aggressive Bayern must be, Inter can’t rest on their laurels in this match. Give Inter a big chance to put the Bundesliga squad away until next season’s Champions League.

2025 Champions League Quarterfinals Leg 2 Pick: Inter Milan

Real Madrid vs. Arsenal

• When
• 2025 Champions League OddsReal Madrid (-155) / Arsenal (+390) / Draw (+320)

Arsenal is up 3-0 on the aggregate, so it makes sense to back Real, which must be ultra-aggressive to have a shot at reaching the semifinals. Still, it’s tough to back Real because the franchise is reeling.

Real will head into this match on a stunning 3-loss streak. There isn’t any cohesiveness with the La Liga power. So if Arsenal pulls off the big-time upset, don’t be surprised since the Gunners are playing much better than their rivals.

The draw, though, feels like the right play. Arsenal will protect their 3-goal lead. Real will take their chances, which could lead to an Arsenal equalizer. A 1-1 match might be the result.

2025 Champions League Quarterfinals Leg 1 Pick: Draw

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