2025 College Football Week 11 Betting Preview
College Football Week 11 promises to be as exciting as College Football Week 10. Reeling LSU heads to Tuscaloosa to take on rival Alabama, while Indiana hopes to keep its winning streak alive versus Penn State in Happy Valley. Oregon faces a tough road test versus Iowa, and the two best teams in the Big 12 battle when Texas Tech hosts BYU. Check out college football odds, analysis, and free picks for what promises to be a wild Week 11.
Top 2025 College Football Week 11 Games to Bet On
Notre Dame is back in the top 10 after a two-month absence. Oklahoma and Texas make the biggest upward moves. See where other top teams land.https://t.co/7dTTUiSC1j
— AP Top 25 (@AP_Top25) November 2, 2025
Indiana vs. Penn State
- When: Saturday, November 8th. 12:00 p.m. ET
- strong>College Football Week 11 Odds: Indiana -714 / Penn State +480
Penn State’s awful season continued in Week 10 when the top team in the nation, Ohio State, blasted the Nittany Lions 38-14. Things won’t get easier for State this Saturday.
Even though they’re at home, the Lions face Fernando Mendoza, the likely Heisman Trophy winner, and the Indiana Hoosiers, one of the best teams in the nation. Indiana knows how to play one way, dominate from beginning to end—the Hoosiers cover.
2025 College Football Week 11 Pick: Indiana
Oregon vs. Iowa
- When: Saturday, November 8th. 3:30 p.m. ET
- strong>College Football Week 11 Odds: Oregon -222 / Iowa +180
Oregon QB Dante Moore projects as the NFL’s top draft pick in April. But that doesn’t mean Moore will beat a stingy Iowa defense on the road.
The Hawkeyes held Mendoza and Indiana to 20 points in a 20-15 loss. Oregon must win this game to ensure a CFP spot. Winning is not a sure thing. The Hawkeyes could pull off the ML upset, but taking the points is the smartest play.
2025 College Football Week 11 Pick: Iowa
BYU vs. Texas Tech
- When: Saturday, November 8th. 12:00 p.m. ET0
- strong>College Football Week 11 Odds: BYU +300 / Texas Tech -385
Tech versus BYU should be fun. The Red Raiders should undoubtedly be the favored team, but we can’t jump all over the home squad knowing that they face one of the better teams in college football. BYU is legit.
The Cougars beat Utah in Utah a couple of weeks ago. Then, in their last, BYU beat Iowa State 41-7. The point spread is too high for a BYU team that can certainly get it done. Take the points and consider a small moneyline play.
2025 College Football Week 11 Pick: BYU
Texas A&M vs. Missouri
- When: Saturday, November 8th. 3:30 p.m. ET
- strong>College Football Week 11 Odds: Texas A&M / Missouri -143
A couple of weeks ago, the A&M Aggies struggled to a 45-42 win over one of the worst teams in the SEC, Arkansas. Don’t let the domination of LSU fool you.
Brian Kelly knew he was out the door, and the LSU offense has been a disaster since Week 1. So, beating LSU by a significant margin should have happened. Beating Missouri by three will be tough. Heck, winning this game won’t be easy for A&M because Mizzou is one of the top teams in the SEC. Aggies lose their first straight up.
2025 College Football Week 11 Pick: Missouri
Auburn vs. Vanderbilt
- When: Saturday, November 8th. 4:00 p.m. ET
- strong>College Football Week 11 Odds: Auburn +230 / Vanderbilt -286
Diego Pavia and the Vandy Commodores almost upset the Texas Longhorns in a 34-31 loss. It took Arch Manning and the Horns to play one of their best games of the season, maybe their best, for the Longhorns to prevail.
The Commodores should have no trouble against Auburn. Teams that beat Vandy do so by going head-to-head with Pavia and the Vanderbilt offense. Auburn can’t score as much as Vanderbilt will in this game. It’s that simple. This one could be a blowout.
2025 College Football Week 11 Pick: Vanderbilt
LSU vs. Alabama
- When: Saturday, November 8th. 7:30 p.m. ET
- strong>College Football Week 11 Odds: LSU +310 / Alabama -417
It isn’t easy seeing LSU do much more than show up and hand the win over to the Alabama Crimson Tide. Alabama is the toughest team in the country after escaping with wins on the road versus Missouri, Georgia, and South Carolina.
The Tide wins. They often don’t win pretty. One thing that’s different in this game? LSU is one of Alabama’s top rivals, on par with Auburn. So expect the Tide to roll.
2025 College Football Week 11 Pick: Alabama
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*All stated odds are subject to change without prior notice.
