2025 College Football Week 7 Betting Preview

By Hank Blaine • October 6, 2025

After a massive College Football Week 6 where the Florida Gators upset the Texas Longhorns and Alabama left no doubt that they’re the team to beat in the SEC, the odds are out for College Football Week 7. The Gators travel to College Station to battle Texas A&M, while Bama heads to Mizzou to take on the Tigers. This Saturday marks the annual Red River Rivalry between the Longhorns and the Sooners. Check out college football odds, analysis, and free picks for College Football Week 7.

Top 2025 College Football Week 7 Games to Bet On

Penn State and Texas dropped out of the AP Top 25 Poll for the first time since 2022 and Miami is back at No. 2. See where other top teams landed.https://t.co/7dTTUiT9QR
— AP Top 25 (@AP_Top25) October 6, 2025

Florida vs. Texas A&M

When: Saturday, October 11th. 7:00 p.m. ET
strong>College Football Week 7 Odds: Florida +235 / Texas A&M -323

A&M should be favored in this game, but the line suggests the Aggies trounce Florida. That’s not going to happen. Sometimes, all it takes is a single player to get an offense going.

D.J. Lagway is ecstatic that Dallas Wilson is finally healthy enough to take to the field for the Gators. Wilson was instrumental, flat-out excellent, versus the Longhorns’ defense, which is one of the best in the nation. Lagway to Wilson could lead to another Florida upset win. For sure, take the points.

2025 College Football Week 7 Pick: Florida

Georgia vs. Auburn

When: Saturday, October 11th. 7:30 p.m. ET
strong>College Football Week 7 Odds: Georgia -4.5 / Auburn +4.5

Auburn is good enough to hang with a Georgia squad that doesn’t rush the ball all that well and doesn’t have nearly the talent on defense that a Kirby Smart team often possesses. Still, it isn’t easy seeing the Tigers winning this.

But we can’t lay the points on the Dawgs in a road game versus a traditional rival. Auburn will do enough to scare UGA fans into thinking another loss is going to happen before the Dawgs, like they did against Tennessee, rally for the 3-point victory.

2025 College Football Week 7 Pick: Auburn

Ohio State vs. Illinois

When: Saturday, October 11th. 12:00 p.m. ET
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strong>College Football Week 7 Odds: Ohio State -833 / Illinois +480

Illinois is a quality football program. However, the Illini have a significant issue in this regard. Illinois allowed Purdue to score 27 points. The Boilermakers might be one of the worst teams in any Power 4 Conference.

On Saturday, the Illini must find a way to put up points versus a defense that has allowed a combined total of 25 points in 6 games. We know the Buckeyes will score. Will Illinois? Maybe not. Lay it.

2025 College Football Week 7 Pick: Ohio State

Alabama vs. Missouri

When: Saturday, October 11th. 12:00 p.m. ET
strong>College Football Week 7 Odds: Alabama -172 / Missouri +133

Alabama has now beaten two ranked SEC opponents in a row, the Georgia Bulldogs and Missouri Tigers. What impresses isn’t how the offense has played, although Ty Simpson is excelling, but how the defense looked shutting down the Dawgs and then Diego Pava and Vandy this past Saturday.

Missouri is a good football team, but Bama might be the best squad in the nation. The Tide are back with a vengeance and want to beat every team they face in the deep SEC. Crimson Tide covers the spread.

2025 College Football Week 7 Pick: Alabama

Indiana vs. Oregon

When: Saturday, October 11th. 3:30 p.m. ET
strong>College Football Week 7 Odds: Indiana +255 / Oregon -357

It’s challenging to lay -9.5 against an Indiana Hoosiers team that is scoring almost at will. However, the Ducks have a significant advantage in this regard. First, Oregon is at home playing on its field at Autzen Stadium.

Oregon rarely plays a bad game on its field. Second, Dante Moore, one of the top recruits in his high school class, pilots Oregon’s offense. Moore is the Heisman favorite after his scorching start to the season. Ducks cover.

2025 College Football Week 7 Pick: Oregon

Oklahoma vs. Texas

When: Saturday, October 11th. 3:30 p.m. ET
strong>College Football Week 7 Odds: Texas Tech -500 / Houston +340

If John Mateer were playing, the Oklahoma Sooners would be the -3.5 chalk. Without Mateer, the onus falls on A.J. Hawkins to get it done for Oklahoma.

But here’s the thing, Hawkins doesn’t have to get it done. Oklahoma’s elite defense faces a mentally fragile quarterback in Arch Manning and a foul Texas offensive line. Also, C.J. Baxter might be out again. The Sooners’ D should carry the day in a win and cover. Take the points for sure.

2025 College Football Week 7 Pick: Oklahoma

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*All stated odds are subject to change without prior notice.