2025 MLB Divisional Round Odds and Preview

The 2025 MLB Divisional Round is here! Early MLB odds suggest that the Milwaukee Brewers and LA Dodgers will make their way to the NLCS, while the New York Yankees and Toronto Blue Jays will face off in the ALCS. The Cubs, Tigers, Phillies, and Blue Jays are underdogs to win their divisional round matchups. Will the favorites prevail, or are we in for a couple of shockers? Check out MLB odds, analysis, and picks for the four divisional round 5-games series.

A Closer Look at the 2025 MLB Divisional Round

And then there were eight. #ALDS #NLDS pic.twitter.com/ZwvyfweGyw

— MLB (@MLB) October 3, 2025

NLDS

Chicago Cubs vs. Milwaukee Brewers

• 2025 NLDS Series Odds: Cubs -105 / Brewers -115

Milwaukee is the favorite because during the regular season, they stormed their way to an NL Central Division title. But the Brewers enter the postseason cold, having gone 4-6 in their last 10 and being outscored by 15 runs.

In contrast, the Cubbies are hot. Chicago went 6-4 in their last 10 with a 2.64 ERA and outscored their opponents by 19 runs. During the regular season, they finished with a 7-6 record. This can go either way. So it makes sense to take the odds on the Cubs.

2025 MLB Divisional Round Pick: Chicago Cubs

LA Dodgers vs. Philadelphia Phillies

• 2025 NLDS Series Odds: Dodgers -130 / Phillies +110

The Dodgers rocked the Cincinnati Reds. Still, this is a betting line that has a lot to do with name recognition. Shohei Ohtani will take the mound for LAD in Game 1 versus the Phillies.

For sure, The Natural can lock down on opposing lineups. But the Phils boast a healthy .282 batting average versus Shohei. They’ve nailed Ohtani for nine home runs in 85 at-bats. Philadelphia can rally in any game in this series versus the Dodgers’ weak bullpen. +106 makes Philly an overlay.

2025 MLB Divisional Round Pick: Philadelphia Phillies

ALDS

Detroit Tigers vs. Seattle Mariners

• 2025 ALDS Series Odds: Tigers +165 / Mariners -192

In 6 games this season, the Seattle Mariners went 4-2 versus the Detroit Tigers. Seattle went 51-30 at home this season, while the Tigers went 40-41 on the road in 2025.

The Mariners are hot, going 7-3 straight up in their last 10. Home park advantage will mean something in this game. Although the +142 on Detroit is tempting, we have to side with the favorites.

2025 MLB Divisional Round Pick: Seattle Mariners

New York Yankees vs. Toronto Blue Jays

• 2025 ALDS Series Odds: Yankees -147 / Blue Jays +127

The favored Yankees went 5-8 straight up versus the Blue Jays during the regular season. The odds suggest NYY is a slam dunk, but the Jays more than held their own in the regular season series and are a good team at home.

Ah, but here’s the thing. No team heads into the divisional round as hot as the Yankees. NYY is a scintillating 9-1 in their last 10. The Yanks have posted a 1.98 ERA during the blistering 10 games and outscored opponents by a ridiculous 29 runs. Home park won’t mean as much because the Yankees, who look like the top play to win the World Series, are on fire.

2025 MLBMLB Divisional Round Pick: New York Yankees

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