2025 NFL Week 10 Betting Preview
Odds for NFL Week 10 are out. Teams like the Indianapolis Colts and Green Bay Packers hope to get back on the winning track after suffering straight-up losses as favorites. Other teams, such as the New England Patriots and Los Angeles Rams, are angling to stay hot heading into the final seven weeks of the regular season. Check out NFL odds, analysis, and free picks for what could be a profitable NFL Week 10.
Top 2025 NFL Week 10 Games to Bet On
NFL Power Rankings for Week 10: We’ve seen this Bills movie before https://t.co/9PuAwCr8JY pic.twitter.com/zjW6dPZvuB
— New York Post (@nypost) November 4, 2025
Atlanta Falcons vs. Indianapolis Colts
- When: Sunday, November 9th. 9:30 a.m. ET
- NFL Week 10 Odds: Falcons +210 / Colts -263
Indianapolis came back to earth big time in a 27-20 loss to the Pittsburgh Steelers. The Colts entered the game as a 3.5 fave. On Sunday, Indy faces an Atlanta team that played well against New England, despite falling by a point.
The Falcons yielded 3.3 yards per rush and sacked Drake Maye 6 times. Daniel Jones and Jonathan Taylor should help the Colts get back to their winning ways, but covering a less-than-respectful spread will be tough.
2025 NFL 10 Pick: Falcons
New York Giants vs. Chicago Bears
- When: Sunday, November 9th. 1:00 p.m. ET
- NFL Week 10 Odds: Giants +150 / Bears -182
The Bears finally utilized top draft pick Colston Loveland to rally for a 47-42 win over the Cincinnati Bengals. Loveland was the top pass catcher and caught TDs, including a 58-yarder to cap the comeback win.
Chicago could bounce in this. The Giants lost by 10 to SF in Week 9, but Jaxon Dart and Devin Singletary started to get the running game going, and the Bears’ D is a mess. Take the points.
2025 NFL 10 Pick: Bears
New England Patriots vs. Tampa Bay Buccaneers
- When: Sunday, November 9th. 1:00 p.m. ET
- NFL Week 10 Odds: Patriots +120 / Buccaneers -143
The Patriots appeared to be on track to roll away from the Atlanta Falcons, but the Falcons rallied to lose by a single point. That’s good news for the Pats heading to Tampa Bay, which hosts the G-Men after a bye.
Expect Tampa to come out playing fast, loose, and as healthy as they have been this entire season. Emeka Egbuka could have a good day against the Patriots’ defense, while Drake Maye and New England are due for a letdown after their sixth straight victory.
2025 NFL 10 Pick: Buccaneers
Los Angeles Rams vs. San Francisco 49ers
- When: Sunday, November 9th. 4:25 p.m. ET
- NFL Week 10 Odds: Rams -185 / 49ers +150
Brock Purdy is expected to be healthy for NFL Week 10, and the Niners did upset the Rams in their first matchup, beating L.A. at SoFi. But the Rams’ D is playing like the best unit in the NFL.
Additionally, when it comes to the Rams versus the 49ers, neither team often achieves a 2-game sweep during the regular season. If it happens, it’s been the Rams in recent seasons. Expect Matt Stafford and his buds to get it done.
2025 NFL 10 Pick: Rams
Pittsburgh Steelers vs. Los Angeles Charger
- When: Sunday, November 9th. 8:20 p.m. ET
- NFL Week 10 Odds: Steelers +129 / Chargers -156
The Chargers struggled against the Titans, only beating Tennessee by 7 points in a 27-20 game. The Bolts should have dominated the worst offense in the NFL, which is why the line is at -3.
Pittsburgh held Jonathan Taylor to 3.3 rushing yards. LAC’s D was terrible versus the Steelers. So if the Steeler defense has finally gotten it together, Rodgers and his mates can win this straight up.
2025 NFL 10 Pick: Steelers
Philadelphia Eagles vs. Green Bay Packers
- When: Sunday, November 9th. 8:15 p.m. ET
- NFL Week 10 Odds: Eagles -120 / Packers +100
Philadelphia was on a bye, and Green Bay suffered an upset loss to the Carolina Panthers. So the trend isn’t good for GB heading into this home matchup versus Jalen Hurts and Philly.
The Eagles should pick up their game starting in Week 10 of the NFL season. A.J. Brown may be healthy enough to play. Even if he isn’t, Saquon Barkley should suit up and have a big night, considering Rico Dowdle dominated the Pack with 130 rushing yards, a 5.2 per rush average, and two touchdowns. Eagles SU is the play.
2025 NFL 10 Pick: Eagles
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*All stated odds are subject to change without prior notice.
READ MORE: 2025 NFL Week 11 Betting Preview
