For the first time since 2016, former ATP Tour heavyweights Andy Murray and John Isner will face one another in a huge tournament. Murray has the backing of the UK home crowd in his favor, while Isner has been a tough out in each tournament he has played in this year. Something’s got to give in this second-round showdown that tennis fans should not miss out on.

Nitrobetting is ready to volley the latest news, tennis betting odds, and updates all year round. This time, let’s break down the upcoming 2022 Wimbledon gentlemen’s singles second-round match between Andy Murray and John Isner, as well as their corresponding odds to win their upcoming battle.

Andy Murray vs. John Isner 2022 Wimbledon Match Information

A moment of mischief from @andy_murray ​​????​#Wimbledon | #CentreCourt100 pic.twitter.com/DM4rAfpVsD

— Wimbledon (@Wimbledon) June 27, 2022

• When: Wednesday, June 29, 2022
• Where: All England Lawn Tennis and Croquet Club, London, England
• TV: ESPN
• Live Stream: ESPN+
• 2022 Wimbledon Betting Odds: Murray (-256) / Isner (+209)

READ MORE: Carlos Alcaraz vs. Tallon Griekspoor 2022 Wimbledon Odds, Preview and Pick

Why Bet on Andy Murray?

A slew of injuries coupled with the global pandemic has put Britain’s very own Andy Murray on the peripheral vision of the ATP Tour scene these past few years. However, with a strong four-set victory over James Duckworth in the first round of the 2022 Wimbledon men’s singles tournament, fans are starting to smell a comeback from the knighted superstar.

Murray held off Duckworth’s 47 winners to just 35 for the former by hitting 16 aces in their first-round battle. The Surrey native also won 48 of a possible 104 points on return against the American, as Murray looks to continue his streak of advancing to the third round of Wimby for the 14th straight time in as many lifetime appearances.

Not only is Murray slowly returning to his “Big Four” form of late, but he’s also been active in grass-court tournaments leading up to the Grand Slam festivities in London. The former two-time Wimbledon champion won seven matches across two prior tournaments on grass this year and nearly defeated Matteo Berrettini in the final round of the BOSS Open in Stuttgart.

Why Bet on John Isner?

Even though John Isner needed all five sets to win his first-round match against Enzo Couacaud, the fact remains that the 20th-seeded entry in the 2022 Wimbledon men’s singles tourney lived up to his high seeding and remains a worthy challenger for the title as we speak.

On the other hand, Isner has been known to crumble in Grand Slam events, considering that he’s never reached the final round of any such tournament across his 15-year career as a pro. Then again, the Greensboro native’s lone semifinal appearance at a Grand Slam tournament did come in London back in the 2018 edition of Wimbledon.

Then again, Isner has to worry less about his Grand Slam performances and more about his next opponent. He has yet win a single match in nine-career showdowns against Murray, albeit with this Wednesday’s match being their first-ever meeting on grass.

Murray vs. Isner 2022 Wimbledon Betting Trends

• Murray is 59-11 lifetime at Wimbledon, with his 84% winning percentage at Wimby being his best amongst all Grand Slam tournaments.
• As hinted upon earlier, Murray is 9-0 lifetime in head-to-head matchups against Isner.
• Isner, meanwhile, has a mere 16-12 record in Wimbledon.
• Isner is 26-17 in his most recent matches, which includes a win at the Atlanta Open last August.

Andy Murray vs. John Isner Expert Betting Prediction

Isner may be the higher seed in this matchup and has put in more work in the ATP Tour scene of late, but tennis fans know better than to bet against Murray at Wimbledon. On the other hand, Murray’s struggles in his bid for a strong comeback has been evident, which may be enough for Isner to finally get one over the smashing Brit for the very first time and also advance to the third round of Wimby for the fifth time in his career.

Where to Bet on 2022 Wimbledon with Crypto

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*All odds stated are subject to change without prior notice.