One of the Champions League’s most anticipated Round of 16 matchups kicks-off on Wednesday, Feb. 22 when Atletico Madrid hosts Manchester United. La Liga power Atletico is a slight underdog to get the victory. Will the Red Devils provide an upset? Or will Atletico protect their pitch?

NitroBetting brings you the Atletico Madrid vs. Manchester United preview, covering everything you need to know about the contest. Below, you will find event details, the latest Soccer odds, and crucial team and player statistics. More than that, we help you lock in on the best picks by providing timely betting trends and expert predictions. Check out for more sports betting odds and lines at our online Bitcoin sportsbook!

Atletico Madrid vs. Manchester United 2022 Champions League Round of 16 Info

? Last time we faced Manchester United. pic.twitter.com/qbi3rlGIeo

— Atlético de Madrid (@atletienglish) February 22, 2022

• When: Wednesday, February 23, 2022, 3:00 PM ET
• Where: Wanda Metropolitano, Madrid, Spain
• TV: CBS
• Live Stream: DAZN.com
• Soccer Odds: Atletico Madrid (+146) / Manchester United (+203) / Draw (+202)

READ MORE: Benfica vs. Ajax 2022 Champions League Odds & Preview (Feb. 23)

Why is Atletico Madrid a safe bet to win?

Atletico may be turning around their form. The Spanish Primera Division squad had lost to Barcelona by 2 goals and to Levante in an upset. But in their last, Atletico blasted Osasuna 3-0. Jao Felix, Luis Suarez, and Angel Correa all scored. Felix got his goal in the first 3 minutes in the victory over Osasuna. The match happened on Feb. 19. So Atletico should enter this with some momentum.

Possible Line-Up

• Oblak
• Savic
• Gimenez
• Reinildo
• Vrsaljko
• Llorente
• Koke
• Kondogbia
• Lodi
• Suarez
• Felix

Atletico Madrid’s Last 5

• Win – 0-3 vs. Osasuna
• Loss – 0-1 vs. Levante
• Win – 4-3 vs. Getafe
• Loss – 4-2 vs. Barcelona
• Win– 3-2 vs. Valencia

Why is Manchester United a safe bet to win?

After struggling versus clubs they should have easily beaten, Man United are back to playing quality soccer. The Red Devils put a 2-0 beating over Brighton & Hove before decimating Leeds United 4-2. Neither Brighton nor Leeds is on the same level as Atletico, but Man U is on fire heading into the match. This is especially true since Bruno Fernandes, Harry McGuire, and Fred scored against Leeds.

Possible Line-Up

• de Gea
• Dalot
• Varane
• Maguire
• Telles
• Fernandes
• McTominay
• Pogba
• Rashford/li>
• Ronaldo
• Sancho

Manchester United’s Last 5

• Win – 2-4 vs. Leeds United
• Win – 2-0 vs. Brighton & Hove
• Draw – 1-1 vs. Southampton
• Draw – 1-1 vs. Burnley
• Loss – 1-1 vs. Middlesbrough

Atletico Madrid vs. Manchester United Betting Prediction

It’s easy to write off Man United because this happens on Atletico’s pitch. Not only that, but United doesn’t always play as a cohesive squad. Sometimes, it seems like the Red Devils aren’t all on the same page.

But before we write off Manchester, it’s important to note that United has played as more of a team in recent matches. The victory over Leeds was a thing of beauty. Everyone seemed to get involved.

When Harry McGuire can score goals before Ronaldo or Jadon Sancho, you know things are going well. The thing about the Red Devils is that when everyone plays together, like Man U did in the win agianst Leeds and Brighton, few teams, not even Man City, can hang with them. United is that deep. What other team can spell Ronaldo with Raphael Varane or Paul Pogba with Fred? Manchester United is deep enough to outlast Atletico in this match. Give the Red Devils the nod on the moneyline.

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