Colts vs. 49ers 2021 NFL Week 7 Odds, Analysis and Prediction

By Carlos Chacon • October 22, 2021

The big question surrounding the Sunday night NFL game in Week 7 is which quarterback starts for the San Francisco 49ers vs. the Indianapolis Colts. Oddsmakers apparently don’t care as the Niners are better than field-goal home favorites.

Not much to go on regarding the last matchup because the teams haven’t played since Oct. 8, 2018, when the Colts beat the visiting 49ers 26-23 in overtime – both teams were pretty bad back then. The starting quarterbacks were Brian Hoyer and Jacoby Brissett, both long gone. Sunday 45th all-time regular season matchup between the teams, with the Colts leading the series at 26-18.

Before anything else, check out this NitroBetting review for a closer look at the Colts vs. 49ers game. We provide the latest information that helps you find the best picks. From essential event details, team and player statistics, the latest NFL betting odds, betting trends, and predictions, we have it all for you. Be sure to check out for the latest sports betting odds and lines at our online Bitcoin sportsbook.

Colts vs. 49ers Game Information

When: Sunday, October 24, 2021, 8:20 PM ET
Where: Levi’s Stadium, Santa Clara, California
TV: NBC
Radio: 107.5 The Fan (Colts) / KNBR 680 AFM (49ers)
Live Stream:NFL Game Pass
NFL Odds: Indianapolis Colts (+4) / San Francisco 49ers (-4)

Why Bet on the Indianapolis Colts?

Indianapolis (2-4) started 0-4 but has won two of three – granted, beating the terrible Dolphins and Texans. Last week’s game vs. Houston was never in doubt, a 31-3 rout. It was the fewest points allowed for an Indianapolis defense since a shutout victory over Dallas in Week 15 of 2018. The Colts tallied three takeaways and have forced a turnover in seven consecutive games, which is the third-longest active streak in the NFL.

Jonathan Taylor rushed 14 times for 145 yards and two touchdowns. He reached 2,000 career scrimmage yards and 1,500 career rushing yards and became just the sixth player in team history to reach each of those plateaus in their first two seasons. Carson Wentz completed 11-of-20 passes for 223 yards and two touchdowns. He has three consecutive games with at least a 115.0 passer rating. Wentz is the fourth Colts quarterback since 2000 to accomplish that feat.

However, three players were injured: receivers Parris Campbell and TY Hilton and safety Julian Blackmon. Campbell could be done for the season with a foot injury and is on IR. In 2021, Campbell saw action in five games (three starts) and caught 10 passes for 162 yards and one touchdown – a 51-yarder vs. Houston. Hilton injured his quad and says he’s 50-50 for Sunday.

Blackmon is done for the year with an Achilles tear. He had 34 tackles, one forced fumble and one pass defended. Blackmon is the 20th player Indy has placed on IR since training camp. One of those, All-Pro guard Quenton Nelson, could be activated this week.

Why Bet on the San Francisco 49ers?

San Francisco (2-3) won its first two games against pretty weak competition but enters on a three-game skid. Starting QB Jimmy Garoppolo missed the team’s Week 5 game, a 17-10 loss at Arizona (Niners come off a bye). In his first NFL start, rookie No. 3 overall pick Trey Lance completed 15-of-29 passes for 192 yards, zero touchdowns and an interception and rushed for 89 yards on 16 carries.

Alas, Lance injured his knee at some point and has not practiced this week through Thursday. “He might have a chance at the end of the week, but I’d be surprised if he’s not ready to go until next week,” Coach Kyle Shanahan said of Lance.

Thus, it’s pretty evident that Garoppolo will be the guy because he has been practicing. He suffered a right calf injury in the first half of the team’s 28-21 loss to the Seahawks in Week 4 but is feeling much better. Pro Bowl left tackle Trent Williams is in question with elbow and ankle injuries but he probably will play.

Meanwhile, Pro Bowl defensive end Nick Bosa’s Nick Bosa’s 5.0 sacks in 2021 are the most by a member of the 49ers in Weeks 1-5 of a season since DT Bryant Young in 2005 (6.0 sacks). The 49ers look for a win coming out of their bye week for the 3rd consecutive season. The team has outscored their opponents 54-23 over the last 2 seasons out of the bye.

Colts vs. 49ers Betting Trends

Colts are 7-2 ATS in the last 9 road games.
Colts are 8-3 ATS in the last 11 games in October.
The total went over in 5 of Indianapolis’ last 6 games on the road.
49ers are 1-4 ATS in the last 5 games following a straight up loss.
49ers are 1-5 ATS in the last 6 home games.
The total went under in 5 of San Francisco’s last 6 games played in October.

Colts vs. 49ers Expert Betting Predictions

Pick: 49ers 24, Colts 23

Check out our latest sports betting guides for the 2021 NFL Regular Season. Stay tuned for more Football previews and articles and don’t forget to check out the latest Football betting odds at our online Bitcoin sportsbook.

*All odds stated are subject to change without prior notice.