The San Diego Padres travel to Illinois to take on the Chicago Cubs in the third faceoff of a four-game series. San Diego hit the hosts hard with two consecutive wins and a seven-run victory in their most recent meeting. The Cubs are now on an eight-game losing streak and are eager to recover from the series of defeats.

Nitrobetting gives you a low down of the upcoming Padres vs. Cubs contest. We highlight important game information, team and player stats, and the latest MLB betting odds. You can also find timely betting odds and predictions that help you secure the best possible picks.

Padres vs. Cubs Game Information

Final: Padres 12, Cubs 5. pic.twitter.com/jNCT7AqGvZ

— Chicago Cubs (@Cubs) June 15, 2022

• When: Wednesday, June 15, 2022, 8:05 PM ET
• Where: Wrigley Field, Chicago, IL
• TV: Bally Sports San Diego, Marquee Sports Network
• Radio: 106.7 The Fan (Padres) / WFRX 95.5 FM (Cubs)
• Live Stream: MLB.tv
• MLB Odds: Padres (+112) / Cubs (-118)

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Why bet on the San Diego Padres?

The Padres have a stellar record of 39-24 this season and top the NL West division. They won seven of the last three games they played with an even impressive 22-11 road record. It’s clear that this team knows how to handle the pressure of playing in uncharted territory as seen in the first two games.

San Diego won the first two games of this series by three runs or more. The team’s pitching staff records a 3.30 ERA, 1.13 WHIP, and a 2.17 opponent batting average since the beginning of their campaign. The Padres scored 284 runs on top of a .237 batting average this season. They also have a .313 on-base percentage.

Manny Machado is batting .315 with ten home runs and 38 RBIs for his side this season. Looking at the possible starting pitcher for the team on Wednesday night, Ryan Weathers is slated to take the mound and make his first appearance of the season.

Why bet on the Chicago Cubs?

The Cubs currently hold fourth place in the NL Central division. The team hasn’t been all that impressive at home with an 11-22 record. Their recent loss in the hands of the Padres marks their ninth defeat in the last ten games. Before losing the first two games of the series, Chicago was swept by the Yankees in a three-game series.

At the moment, the Cubs average 4.23 runs while allowing 4.98 runs per game. The pitching staff registers a 4.70 ERA, 1.34 WHIT, and a .252 opponent batting average. Chicago has 259 runs with a .242 batting average and .318 on-base percentage this season. Patrick Wisdom has been the most relevant player on the team since the calendar began, hitting 12 home runs and driving in 31 RBIs.

Starting for the Cubs on Wednesday night is Caleb Kilian. This marks his first start of the year and comes in with a clean slate. He holds a 5.40 ERA and a 1.00 WHIP over five innings pitched this season.

Padres vs. Cubs MLB Betting Trends

• The Padres are 6-4 in their last ten road games.
• The Padres are 4-6 in their last ten road games against the Cubs.
• The totals have gone over in three of the Padres’ last five road games.
• The Cubs are 4-6 in their last ten games at Wrigley Field.
• The Cubs are 6-4 in their last ten games against the Padres.
• The totals have gone under in three of the Cubs’ last five home games.

Padres vs. Cubs Betting Prediction

Both teams have some uncertainty looking at their starting pitchers. The Padres starting Ryan Weathers remains a gamble despite holding onto a 5.32 career ERA and a 1.38 career WHIP. For the hosts, going with Caleb Kilian who allowed three runs over five innings pitched might work to their disadvantage seeing as they struggled in their recent games. It also doesn’t help that San Diego has been on form in the past few weeks. The Padres have a slight edge over the Cubs but don’t overlook a hopeful Chicago Cubs team covering.

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*All odds stated are subject to change without prior notice.