Red Sox vs. Astros 2021 MLB ALCS Game 6 Odds, Preview, and Prediction

On the strength of back-to-back wins in Fenway Park, the Houston Astros are now just one win away from advancing to the 2021 World Series. With the last two games shifting back to the Lone Star State, will the Boston Red Sox be able to force a winner-take-all Game 7 with a win in Friday night’s elimination road game?

NitroBetting is here to deliver the latest Major League Baseball news and coverage from the 2021 MLB playoffs and beyond. This time, let’s take a look at the crucial matchup between the Boston Red Sox and the Houston Astros in Game 6 of the ALCS. Be on top of all the developments by tuning in to the MLB odds, previews, and predictions for all the exciting postseason baseball action ahead.

Red Sox vs. Astros 2021 MLB ALCS Game 6 Information

  • When: Friday, October 22, 2021, 8:08 PM ET
  • Where: Minute Maid Park, Houston, Texas
  • TV: FS1
  • Radio: WEEI-FM 93.7 FM (Red Sox) // 790AM KBME (Astros)
  • Live Stream: MLB.tv
  • MLB Odds: Red Sox (+105) / Astros (-115)

Why bet on the Boston Red Sox?

After a massive 12-run explosion in Game 3 to get their three-game playoff homestand off on the right foot, the Boston Red Sox have since stumbled towards two consecutive losses to the Houston Astros. Wednesday’s 9-1 loss marked the second-straight game that the Red Sox have allowed nine runs to the Astros, whereas Alex Cora’s boys from Beantown have mustered up just a total of three runs and eight hits across those two defeats.

Starting pitcher Nathan Eovaldi has the tough task of limiting a resurgent Houston offense this Friday night. Eovaldi is making his third appearance in the series, with his recent stint as a reliever in Game 4 going horribly, as he allowed four runs on two hits in less than an inning of work as the Astros cruised to an easy 9-1 win.

Can the Red Sox get any more playoff magic from Kike Hernandez? Boston’s franchise playoff record-setting leadoff hitter went 0-for-4 on Wednesday and is 1-of-9 across his team’s last couple of losses. Hernandez will need to provide a spark on offense for the Sox to stand a chance at living to fight another day.

Why bet on the Houston Astros?

The Houston Astros’ redemption saga is going according to plan, as their big bats have woken up just in time to hopefully capture the 2021 ALCS title on a strong note. They’re averaging a whopping 6.2 runs per game this series and are in prime position to send the Red Sox home with the last two games in their own home field.

While it’s great to see Houston’s superstars Jose Altuve, Yordan Alvarez, Carlos Correa, and Yuri Gurriel all having a blast on the attack, it’s the team’s pitching unit that deserves a lot more credit. The Astros were also susceptible to giving up tons of runs to Boston earlier in the series, but that has all changed over their last two outings.

Unfortunately, Luis Garcia is on tap as their starter on Friday. Garcia had an early second-inning exit in Game 2’s loss to the Red Sox due to discomfort in his knee. That injury occurred after the 24-year-old Venezuelan righty gave up a grand slam to Boston’s J.D. Martinez in the very first inning.

Red Sox vs. Astros MLB Betting Trends

  • The Red Sox are 5-2 in their last seven road games.
  • The Sox are also 5-2 in postseason games wherein they were slated as underdogs.
  • The run totals have gone over in all three of Boston’s most recent playoff games on the road.
  • The Astros won five consecutive postseason games at home prior to their aforementioned Game 2 defeat.
  • The Astros are 8-4 against the Red Sox this season, including their ALCS matchups.
  • The totals have gone over in seven straight meetings between Houston and Boston.

Red Sox vs. Astros Series Betting Prediction

There’s no question that the Astros have fantastic momentum and home-field advantage to give them a significant edge in Game 6. On the other hand, the entire ALCS have swung wildly with runs aplenty being scored by both teams, and the Red Sox in desperation mode can certainly heat up in a hurry in order to save their season. Considering the high-scoring affairs in the series, perhaps placing stakes on the over-under would be a better move in order to better enjoy what could be the conclusion of this intense series.

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*All odds stated are subject to change without prior notice.