NCAAF handicappers can expect big time college football upsets each and every season. The 2021 season is no different. After scouring schedules, we discovered the biggest eight potential college football upsets of the year. The games listed below are moneyline upsets, which means we believe the underdog beats the favorite straight up.

Predicting College Football Biggest Betting Upsets in 2021

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Northern Arizona beats Arizona on Sep. 18

The Arizona Wildcats’ over/under win total is 2 ½. We don’t think AZ wins a single game this season, which means even interstate FCS squad Northern Arizona beats the Wildcats. Before calling us crazy, don’t forget that Arizona most likely has a less talented roster than the Lumberjacks. The Wildcats must start a freshman at quarterback, either Gunner Cruz or Will Plummer, while NAU will start Oklahoma State graduate student Keondre Wudtee.

Wisconsin upsets Notre Dame on Sep. 25

Notre Dame won’t be a horrible team, but Wisconsin should be the best, at worst second-best, team in the Big Ten. The Badgers start four seniors, including Tyler Beach, along the offensive line, a redshirt freshman running back in Jalen Berger who averaged 5 yards per carry last season, and a defense with 7 seniors, 3 juniors, and a sophomore. Again, Notre Dame isn’t a bad team. But we’re dreaming if we don’t think the Badgers can beat the Irish.

Indiana upsets Ohio State Oct. 23

Ohio State always replenishes. So that’s not the reason to like Indiana. The main reason to believe the Hoosiers upset the Buckeyes is because Michael Penix Jr. returns to play quarterback. Penix Jr. is a dark horse Heisman Trophy candidate. He’s got skills for days. The fact Penix Jr. faces the Buckeyes on Indiana’s field should give Hoosier fans confidence. Don’t be surprised if Indiana upsets mighty Ohio State.

North Carolina upsets Notre Dame on Oct. 30

Sam Howell Jr. is one of the best overall players in college football. He may be the best quarterback, or at least the second-best, in NCAAF this season. Notre Dame hosts UNC, which gives them the edge. But the Irish play Wisconsin, Cincinnati, are at Virginia Tech, and host USC in the four games before taking on the Tar Heels. Notre Dame will lose at least 2 games in the 5-game gauntlet. The Heels and the Badgers should provide the 2 losses.

Ole Miss upsets LSU on Oct. 23

This year’s surprise SEC team will be Lane Kiffin coached Mississippi. The Rebels are loaded on offense, and the defense sends mostly seniors to the field. More importantly, LSU may not bounce back from a disappointing 2020 the way, so many expect they will. The Tigers from Baton Rouge are down to a couple of quarterbacks and both are underclassmen, sophomore Max Johnson and freshman Garrett Nussmeier. Also, even though Louisiana State sends the top overall defensive player in college football to the gridiron, cornerback Derek Stingley Jr., the rest of the D is unproven. Kiffin’s loaded offense should have no trouble scoring TD after TD against LSU.

Ole Miss upsets Texas A&M on Nov. 13

The Rebels won’t just upset LSU. Ole Miss will also beat Top 10 ranked Texas A&M. The Aggies defense should be great. But Kiffin’s offense will score close to 40 points per, if not more than 40 each game. Even if A&M holds Ole Miss to 28 or 35, the offense will have trouble scoring because Jimbo Fisher doesn’t have a quarterback that is as talented as last year’s starter, Kellen Mond.

Iowa State beats Oklahoma on Nov. 20

Oklahoma quarterback Spencer Rattler is the Heisman Trophy favorite. Under defensive coordinator Alex Grinch, the Sooners defense has improved the past couple of seasons. What’s not to like about Oklahoma? Nothing except on Nov. 20, the Sooners face the senior and junior laden Iowa State Cyclones. While Rattler is the overall favorite, Iowa State sends a couple of Heisman Trophy contenders, QB Brock Purdy and RB Breece Hall, to the field.

Not only that, but the Cyclones start 3 seniors, a junior, and a sophomore along the offensive line. Also, the defense shows a graduate transfer, 7 seniors, 2 juniors, and a sophomore. If this is Iowa State’s season, and on paper it looks like it is, the Cyclones will beat Oklahoma straight up.

Michigan upsets Ohio State Nov. 27

We saved our biggest betting upset for last. Ohio State has owned coach Jim Harbaugh and the Wolverines. It’s gotten so bad that Michigan fans don’t even mention trying to beat the rival Buckeyes anymore.

Most Wolverine fans chalk up the final game of the season as a loss. But this season, things could turn around for Michigan and the maize and blue faithful. Ohio State is talented, but they’re also, like in every season, ultra-young. Michigan starts 4 seniors, 6 juniors, and a sophomore on offense. On defense, the Wolverines start 6 seniors and 5 juniors.

If Harbaugh is ever going to beat the Ohio State Buckeyes, this is the season he does it.

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