2022 US Open Men’s Round 2 Betting Preview

By Hank Blaine

Top matchups happen at the U.S. Open Women’s Singles tournament on Wednesday. One of the most heated should be Bianca Andreescu throwing down against 15-seed Beatriz Haddad Maia. Also on Wednesday, 3-seed Maria Sakkari steps onto the court a massive favorite versus Xiyu Wang and 5-seed Ons Jabeur takes on Elizabeth Mandik. See below for tennis odds, analysis, and free picks for six fantastic U.S. Open Women’s tennis matches happening in round 2.

Betting Predictions for Round 2 of the 2022 US Open Men’s Singles Tournament

  • When: Wednesday, August 31
  • Where: Flushing Meadows, New York, NY
  • Streaming: ESPN+

READ MORE: 2022 US Open Women’s Round 2 Betting Preview

Daniil Medvedev vs. Arthur Rinderknech

French tennis player Arthur Rinderknech played a great match to get by Quentin Halys. Rinderknech ended Halys’ night in the 5-match slugfest by winning the final two sets 6-3, 6-2.

For his efforts, Arthur must take on the top player on the ATP Tour. Daniil Medvedev handled Stefan Kozlov 6-2, 6-4, 6-0 in his first round match. A similar effort from Medvedev will lead to a win and cover in this.

2022 US Open Pick: Daniil Medvedev -8.5 -118

Nuno Borges vs. Yibing Wu

Underdog Nuno Borges should have zero energy in this match. Borges and opponent Ben Shelton played 8 sets in the first round. Borges won the final set 6-3. Yibing Wu beat 31-seed Nikoloz Basilashvili in straight sets: 6-3, 6-4, 6-0. Wu will take advantage of a tired Borges. The chalk wins.

2022 US Open Pick: Yibing Wu -286

Alejandro Tabilo vs. JJ Wolf

Alejandro Tabilo fought hard to move to the second round. Kamil Machrkaz pushed the underdog in this to 5 sets. On Wednesday, Tabilo can’t take a break because he faces a strong favorite in J.J. Wolf.

Although Wolf is 7-7 in singles titles this season, he finished off 16-see Roberto Bautista Agut in straight sets in round 1. Wolf is playing great tennis. The chalk can cover.

2022 US Open Pick: JJ Wolf -5.0 -111

Karn Khachanov vs. Thiago Monteiro

In his first round match, Thiago Monteiro dropped Alex Molcan 6-4, 4-6, 6-4, 6-1. If Monteiro hopes to beat Karn Khachanov, he must play better in the second round.

After dropping the first set versus Denis Kudla, Khachanov turned it on and won the next three sets 6-1, 6-2, 6-2. Khachanov shouldn’t let up. Lay the games on the chalk.

2022 US Open Pick: Karn Khachanov -5.5 -102

Andy Murray vs. Emilio Nava

Murray played well in his first match, beating Francisco Cerundolo in 4 sets, which is the reason he’s a massive favorite to take down underdog Emilio Nava.

Nava required 7 sets to get by John Millman. No doubt, Murray should win this. But since Nava is 20-years-old, he figures to bounce back after the brutal round 1 match. Nava offers fair odds to end Murray’s U.S. Open run.

2022 US Open Pick: Emilio Nava +373

Hugo Grenier vs. Matteo Berrettini

After dropping the first set in his round 1 match, Hugo Grenier poured it on, ending Tomas Martin Etcheverry’s U.S. Open in 3 straight sets. On August 31, though, Grenier faces a player that can lift the trophy.

Berrettini has won 2 singles titles this season. Matteo is 21-9 in singles matches and beat Nicolas Jarry in straight sets in his first round match. The chalk covers the spread.

2022 US Open Pick: Matteo Berrettini -6.5 -108

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