NFL Week 16 kicks off on Thursday with a game that has massive NFC Playoff implications. The New Orleans Saints and L.A. Rams remain playoff contenders. Then on Saturday, Cincinnati hopes to continue their playoff push when the Bengals take on the Steelers in Pittsburgh. Sunday has plenty of playoff implication action, including Detroit hosting Minnesota. Check out against the spread NFL odds, analysis, and free picks for every game on the NFL Week 16 schedule.

Top 2023 NFL Week 16 Games to Bet

NFL Power Rankings for Week 16: Beware of the Bills https://t.co/1WIdARNuhk pic.twitter.com/kuB5YbS99H

— New York Post (@nypost) December 19, 2023

READ MORE: 2023 NFL Week 16 Sleeper Picks

New Orleans Saints vs. Los Angeles Rams

• When: Thursday, December 21st, 2023. 8:15pm EST.
• Where: SoFi Stadium, Inglewood, CA
• NFL Odds: Saints (+4) // Rams (-4)

The Saints defense has begun to really pick things up. For the second straight game, the Saints didn’t allow an opponent, this time it was Tommy DeVito and the Giants, from score double- digits. The Saints D keeps this to within the spread line.

2023 NFL Week 16 Pick: New Orleans Saints

Cincinnati Bengals vs. Pittsburgh Steelers

• When: Saturday, December 23rd, 2023. 4:30pm EST.
• Where: Acrisure Stadium, Pittsburgh, PA
• NFL Odds: Bengals (-1.5) // Steelers (+1.5)

The Saints defense has begun to really pick things up. For the second straight game, the Saints didn’t allow an opponent, this time it was Tommy DeVito and the Giants, from score double- digits. The Saints D keeps this to within the spread line.

2023 NFL Week 16 Pick: Cincinnati Bengals

Buffalo Bills vs. L.A. Chargers

• When: Saturday, December 23rd, 2023. 4:30pm EST.
• Where: SoFi Stadium, Inglewood, CA
• NFL Odds: Bills (-10) // Chargers (+10)

After a stunning road win against the Kansas City Chiefs, many believed the Bills might fall apart versus the Cowboys. Buffalo didn’t, instead, dominating in a blowout win.

The Chargers fired coach Brandon Staley. Still, Justin Herbert remains injured. But the line is a lot. So taking the 10 points is the play.

2023 NFL Week 16 Pick: L.A. Chargers

Detroit Lions vs. Minnesota Vikings

• When: Sunday, December 24th, 2023. 1:00pm EST.
• Where: U.S. Bank Stadium, Minneapolis, MN
• NFL Odds: Lions (-3.5) // Vikings (+3.5)

Detroit stepped it up big time against the scorching Denver Broncos in NFL Week 16, rushing out to a 21-0 halftime lead. Denver couldn’t recover. The Lions will find it more difficult to beat Brian Flores’ defense in what will be a close game.

2023 NFL Week 16 Pick: Minnesota Vikings

Indianapolis Colts vs. Atlanta Falcons

• When: Sunday, December 24th, 2023. 1:00pm EST.
• Where: Mercedes-Benz Stadium, Atlanta, GA
• NFL Odds: Colts (+1.5) // Falcons (-1.5)

Indianapolis is better than the Atlanta Falcons. We know this because in NFL Week 15, the ATL lost to the Carolina Panthers in a 9-6 barn burner. The Colts will score much more than 9, which means Atlanta’s offense will have to keep pace, something it won’t do.

2023 NFL Week 16 Pick: Indianapolis Colts

Cleveland Browns vs. Houston Texans

• When: Sunday, December 24th, 2023. 1:00pm EST.
• Where: NRG Stadium, Houston, TX
• NFL Odds: Browns (+2.5) // Texans (-2.5)

As long as C.J. Stroud is out, the Texans are going to find it difficult to beat quality teams like the Cleveland Browns. Joe Flacco threw for 374 yards against the Bears in the week 15 victory. Flacco may not need to throw for as many yards to beat the Texans.

2023 NFL Week 16 Pick: Cleveland Browns

Seattle Seahawks vs. Tennessee Titans

• When: Sunday, December 24th, 2023. 1:00pm EST.
• Where: Nissan Stadium, Nashville, TN
• NFL Odds: Seahawks (-2.5) // Titans (+2.5)

Tennessee lost their last game versus the Houston Texans. However, the defeat came in overtime. Seattle must play Philadelphia on Monday night. So this won’t be an easy game for the Seahawks after having to face the NFC champs. Titans cover.

2023 NFL Week 16 Pick: Tennessee Titans

Washington Commanders vs. New York Jets

• When: Sunday, Dece mber 24th, 2023. 1:00pm EST.
• Where: MetLife Stadium, East Rutherford, NJ
• NFL Odds: Commanders (-2.5) // Jets (+2.5)

Washington is a disaster, but the Jets may have to play this game without Zach Wilson who got injured in a blowout loss to the Dolphins on Sunday. The Commanders could do just enough to keep this to a 3-point loss.

2023 NFL Week 16 Pick: Washington Commanders

Green Bay Packers vs. Carolina Panthers

• When: Sunday, December 24th, 2023. 1:00pm EST.
• Where: Bank of America Stadium, Charlotte, NC
• NFL Odds: Packers (-3.5) // Panthers (+3.5)

The Panthers could win this straight up. Green Bay did nothing against Baker Mayfield and the Tampa Bay Buccaneers in a home loss. The loss sent Green Bay to 6-8, which means the Green Bay can make the playoff thesis is dead.

2023 NFL Week 16 Pick: Carolina Panthers

Jacksonville Jaguars vs. Tampa Bay Buccaneers

• When: Sunday, December 24th, 2023. 4:05pm EST.
• Where: Raymond James Stadium, Tampa, FL
• NFL Odds: Jaguars (+1) // Buccaneers (-1)

Jacksonville will find it tough to get by the Tampa Bay Buccaneers. Tampa is playing excellent football because Baker has put the Bucs on his back. Jacksonville will continue to have offensive line issues. So Tampa gets the nod.

2023 NFL Week 16 Pick: Tampa Bay Buccaneers

Arizona Cardinals vs. Chicago Bears

• When: Sunday, December 24th, 2023. 4:25pm EST.
• Where: Soldier Field, Chicago, IL
• NFL Odds: Cardinals (+4) // Bears (-4)

For a while, a quarter, almost an entire half, the Cardinals hung with the San Francisco 49ers. But then Arizona remembered who they are, and the Niners remembered who they are.

The Bears played too well to lose against the Cleveland Browns. At home, Chicago should easily beat Zona by 4 or more.

2023 NFL Week 16 Pick: Chicago Bears

Dallas Cowboys vs. Miami Dolphins

• When: Sunday, December 24th, 2023. 4:25pm EST.
• Where: Hard Rock Stadium, Miami Gardens, FL
• NFL Odds: Cowboys (+1.5) // Dolphins (-1.5)

Dallas’s 31-10 loss to Buffalo was flat out embarrassing. Things don’t get easier for the Cowboys because on Sunday, they face the Miami Dolphins on the road.

Yes, Tyreek Hill may not play. Even if he doesn’t, the Boys are a different team on the road than they are at AT&T Stadium, Cowboys lose their second straight SU and ATS.

2023 NFL Week 16 Pick: Miami Dolphins

New England Patriots vs. Denver Broncos

• When: Sunday, December 24th, 2023. 8:15pm EST.
• Where: Empower Field at Mile High, Denver, CO
• NFL Odds: Patriots (+5.5) // Broncos (-5.5)

At one point in their NFL Week 15 game versus the Kansas City Chiefs, the Patriots had a 10-7 lead. The lead didn’t last long. The final score was KC 27 and New England 17.

Denver tried to rally against the Detroit Lions, but the Broncos couldn’t dig themselves out of a 21-0 hole. Denver won’t have so much trouble versus the Patriots at Mile High. Back the Colorado Ponies to cover.

2023 NFL Week 16 Pick: Miami Dolphins

Las Vegas Raiders vs. Kansas City Chiefs

• When: Sunday, December 24th, 2023. 1:00pm EST.
• Where: GEHA Field at Arrowhead Stadium, Kansas City, MO
• NFL Odds: Raiders (+9.5) // Chiefs (-9.5)

The Raiders are good enough to keep this to within a 9 points loss. Las Vegas absolutely dominated the rival Chargers in their last, scoring 63 points in an unbelievable performance. Kansas City should win, but the Chiefs aren’t dominating teams. They haven’t for a while. Take the points.

2023 NFL Week 16 Pick: Las Vegas Raiders

New York Giants vs. Philadelphia Eagles

• When: Monday, December 25th, 2023. 4:30pm EST.
• Where: Lincoln Financial Field, Philadelphia, PA
• NFL Odds: Giants (+10.5) // Eagles (-10.5)

It’s tough to lay so many points on the Eagles. Philadlephia’s defense has struggled in the second half of the season. The issues have been so prevalent that Matt Patricia called the defensive plays versus Seattle in Philly’s NFL Week 15 game.

No matter who calls the defensive plays in this, the Giants, as long as Tommy DeVito steps onto the field, will keep the score closer than the spread line.

2023 NFL Week 16 Pick: New York Giants

Baltimore Ravens vs. San Francisco 49ers

• When: Monday, December 25th, 2023. 8:15pm EST.
• Where: Levi’s Stadium, Santa Clara, CA
• NFL Odds: Ravens (+5.5) // 49ers (-5.5)

The Niners are the best team in the NFL. So although the spread is somewhat high because San Francisco must face Lamar Jackson, no team can hang with the 49ers. Lay the points on San Francisco to make a statement.

2023 NFL Week 16 Pick: San Francisco 49ers

Where to Bet On NFL with Bitcoin

NFL odds are available all year round here at Nitrobetting. Create a Nitrobetting account now to win tons of Bitcoin from the 2023 NFL season with our up-to-date NFL futures odds, as well as our special Bitcoin Squares and Picks contests throughout the upcoming season!

Check out our latest Bitcoin betting guides for the 2023 NFL season. Stay tuned for more football previews and articles, and don’t forget to check out the latest NFL betting odds at our online Bitcoin sportsbook.