Major League Baseball’s Opening Day is Thursday, March 28. On opening day, two massive matchups take place when the Atlanta Braves, the second choice to win the 2024 World Series after the L.A. Dodgers, throw down against the NL East rival Phillies in Philadelphia. Also on Thursday, the New York Yankees take on the Astros in Houston. Check out 2024 MLB Opening Day favorite picks for Thursday, March 28.

A Closer Look at 2024 MLB Opening Day

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Atlanta Braves vs. Philadelphia Phillies

Braves versus Phillies should be epic. Sure, it’s game 1 of 162, but who cares? It’s still Braves versus Phillies.

The ATL sends Cy Young chalk Spencer Strider to the mound. Because Strider takes the hill, the Braves should be slight favorites over their NL East rivals. Strider holds Philadelphia to a .192 batting average as a team. Spencer has struck out 79, given up just 38 hits, and allowed just 8 home runs in 198 Philadelphia at-bats.

2024 MLB Opening Day Pick: Atlanta Braves

Minnesota Twins vs. Kansas City Royals

Royals starter Cole Ragans has the makings of a decent starter. But Ragans should be in some trouble facing under the radar World Series contender Minnesota.

Pablo Lopez, who has climbed to second choice to win the AL Cy Young now that Gerrit Cole is on the pine with an injury, heads to the mound for the Twins. Pablo should dominate a KC lineup that lacks power.

2024 MLB Opening Day Pick: Minnesota Twins

New York Yankees vs. Houston Astros

If Gerrit Cole were throwing, it would be a different story in Yanks versus Stros. Cole has an elbow issue with no real timetable on a return.

So the Yankees will go with Nestor Cortes and his 4.97 ERA. Framber Valdez, Houston’s starter, may not have to lock down Yankees’ batters for the Astros to win. Also consider going over even if the line seems too high.

2024 MLB Opening Day Pick: Houston Astros

Detroit Tigers vs. Chicago White Sox

The White Sox hope Garrett Crochet can transition from reliever to starter. The fact Crochet heads to the hill in the Chi-Sox’s opening day game means Chicago doesn’t have much behind him.

Detroit is sneaky good enough to make the postseason. If they do it will be because Tarik Subal, Thursday’s starter, leads the way. Subal contains Chicago’s lineup.

2024 MLB Opening Day Pick: Detroit Tigers

Washington Nationals vs. Cincinnati Reds

This should be an entertaining matchup. Nationals starter Josiah Gray posted a decent 3.91 ERA last season.

The Reds, though, are tough to beat at home. Not only that, but Cincinnati had a great spring training and Cincy tends to start out hot in late March and April only to tail off in the summer. Frankie Montas should throw well enough to set up the bullpen for a save.

2024 MLB Opening Day Pick: Cincinnati Reds

Colorado Rockies vs. Arizona Diamondbacks

Back the run line on the D’Backs. Although Arizona is +4000 to win the World Series, the team is one of the top clubs in MLB.

The Rockies are projected to post the worst record of the season. Also, Zac Gallen, a legit Cy Young contender, takes the mound for Arizona. D’Backs roll.

2024 MLB Opening Day Pick: Arizona Diamondbacks

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READ MORE: 2024 MLB Opening Day Underdog Betting Picks