The 2024 Major League Baseball Season threw first pitch on March 20 when the San Diego Padres fell to the L.A. Dodgers. The regular season for all other teams begins this Thursday, March 28 on opening day. Which underdogs have the best chance of scoring victories in their first games of the season? Check out six of the best underdog plays happening on Major League Baseball Opening Day 2024.

A Closer Look at 2024 MLB Opening Day

️ days until #OpeningDay ⚾️ pic.twitter.com/VXv6gMJ0Iv

— MLB Network (@MLBNetwork) March 23, 2024

Milwaukee Brewers vs. New York Mets

Jose Quintana, the New York Mets’ listed opening day starter, went 3-6 last season. But Quintana’s ERA, 3.57, was comparable to Freddy Peralta’s, which is why the assumption is that since this happens in Queens, the Mets will be the chalk.

No matter if the Brewers are the favorite at the time you wager on this one. Milwaukee went through major changes. So if they are favored over the Mets, it won’t be by much. In any case, change is good and Peralta should be sharp in his first official outing.

2024 MLB Opening Day Pick: Milwaukee Brewers

Los Angeles Angels vs. Baltimore Orioles

Baltimore is World Series contender while most believe there’s a change the Angels finish in last place in the deep AL West. Seattle, Houston, and Texas are three ALCS and Fall Classic quality teams.

Yes, the Halos should finish ahead of the A’s. But that won’t help them on opening day against the Orioles. Still, Corbin Burnes, the O’s starter on Thursday, posted a 3.39 ERA throwing in the NL in 2023. Changing leagues can be as tough on pitchers as it is on hitters. The Angels have a shot.

2024 MLB Opening Day Pick: Los Angeles Angels

St. Louis Cardinals vs. Los Angeles Dodgers

Talk about distractions. Shohei Ohtani lends, or gives, his interpreter to pay off gambling debts to an illegal book operator in California under FED investigation?

Can you think of more distracting way for the Dodgers to start the season? On paper, LAD takes Miles Mikolas, St. Louis’ starter, to task. But Tyler Glasnow comes off a great performance last week. So Glasnow could bounce, which means the Cards can get it done given the Dodgers’ Shohei issue.

2024 MLB Opening Day Pick: St. Louis Cardinals

Toronto Blue Jays vs. Tampa Bay Rays

Jays’ starter Jose Berrios is a terrific pitcher. However, this is a home game for the Rays, which always seem to contend even though they go through big changes every offseason.

Still, it will be rare to see Toronto take on Tampa as a dog in 2024. The only reason they will be the dog on Thursday is because Zach Eflin picks up the ball for the Rays and Eflin had a good 2023.

2024 MLB Opening Day Pick: Toronto Blue Jays

Chicago Cubs at Texas Rangers

The Rangers will be the big time chalk because the defending champs send Nathan Eovaldi and his 12-5 2023 record and 3.63 ERA to the hill.

But the Cubs counter with Justin Steele, who could take the next step into starting pitcher superstardom after a stellar 2023 where he posted a stellar 3.06 ERA. The Cubbies are legit. They prove it on Thursday.

2024 MLB Opening Day Pick: Chicago Cubs

Boston Red Sox vs. Seattle Mariners

Seattle starter Luis Castillo is one of the favorites to win the Cy Young in 2024. Castillo hopes to get off to a good start.

However, the Red Sox might have an ace on their hands. Brayan Bello is just 24 years old. He posted a decent ERA last season, 4.24, in his first in the majors. If Bello improves in 2024, he could lead the Red Sox to the postseason. Boston is worth a look.

2024 MLB Opening Day Pick: Boston Red Sox

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READ MORE: 2024 MLB Opening Day Favorite Betting Picks