49ers vs. Chargers 2021 NFL Preseason Week 2 Odds and Preview

By Carlos Chacon • August 20, 2021

The San Francisco 49ers and Los Angeles Charges give us an early glimpse into the Battle of California in the NFL preseason. Catch both teams from the SoFi stadium as they try to build some pace before taking on the regular season. Both teams have played one game so far, with the 49ers missing a win by three points against the Chiefs, and the Chargers claiming an opening game victory over other Los Angeles rivals, the Rams.

The preseason is coming to an end and the new 2021 NFL season unfolds before us, and it’s always great to see the teams get into the zone before going all out. With that, NitroBetting gives you an early look at the upcoming 49ers vs. Chargers game. We point you in the direction of the best picks with the help of timely betting trends and our very own expert betting predictions. More than that, we share important game information, team and player facts, and the latest NFL betting odds. Don’t forget to check out the latest 2021 NFL Preseason odds at out online Bitcoin sportsbook.

San Francisco 49ers vs. Los Angeles Chargers Game Information

When: Sunday, August 22, 2021, 7:30 PM ET
Where: SoFi Stadium, Inglewood, California
TV: CBS, Fox, NBC
Radio: KGO 810-AM (49ers) / KYSR 98.7 FM (Chargers)
Live Stream:NFL Game Pass
NFL Odds: San Francisco 49ers (-233) / Los Angeles Chargers (+298)

Why Bet on the San Francisco 49ers?

As San Francisco recovers from an erratic 2020 season, finishing 6-10 overall, they find new light in Trey Lance. But there’s the question if he can handle the pressure of the NFL or not. To silence critics, he gave the Niners a reason to be excited about the year after going 5 of 14 for 128 yards and a touchdown.

He kept the team in the game, despite suffering the 19-16 home loss to the Chiefs. This adds competition into the starting quarterback position, and we expect Jimmy Garoppolo to put in the work. In any case, the team is in good hands.

The Niners also completed 175 rushing yards and a touchdown on 29 carries against Kansas City. That’s a backfield that could put plenty of stress on LA’s defense on Saturday. The 49ers’ offensive line was inconsistent in Week 1 of the preseason, but expect Kyle Shanahan to hold back some of its parts in this game to avoid any risk of injury to his starters. Nevertheless, we look forward to a heated battle between the two California teams this Sunday.

Why Bet on the Los Angeles Chargers?

Meanwhile, the Chargers were in a similar situation as the 49ers last season. San Francisco finished 7-9 for third place in the AFC West. It was the Niners’ second consecutive year not qualifying for the playoffs, but the team was able to improve on their 2019 record with four straight wins to close the season. With Brandon Stanley as head coach, we get to see if he can introduce changes that can make the team more competitive this year.

True enough, the Chargers came away with a 13-6 victory in their first 2021 NFL preseason game. With a solid defensive presence and enough offensive firepower, they were able to deliver. They held their opponents to 197 yards and recorded one interception, while Nick Niemann, Emeke Egbule, and Chris Rumph II made sure that all defensive measures were in play. Furthermore, if we see Justin Herbert suit up in Week 2, the Chargers can close the gap and back the 49ers into a corner.

49ers vs. Chargers Betting Trends

The 49ers are 1-4 in their last 5 games.
The 49ers are 2-3 against the spread in their last 5 games.
The totals have gone under in 2 of the 49ers’ last 5 games.
The Chargers are 4-1 in their last 5 games.
The Chargers are 4-1 against the spread in their last 5 games.
The totals have gone over in 2 of the Chargers’ last 5 games.

49ers vs. Chargers Expert Betting Predictions

The 49ers enter the game as favorites. They had the edge on the Chargers in a few key categories and can extend the gap if they play aggressively again. Of course, that’s not to say that the Chargers are out of the winning discussion. There’s still a good chance they cover the spread, and if everything goes according to plan, even a win is possible. Ultimately, preseason games can be tricky to predict, but we expect great football action coming from both sides.

Check out our latest sports betting guides for the 2021 NFL Preseason. Stay tuned for more Football previews and articles and don’t forget to check out the latest Football betting odds at our online Bitcoin sportsbook.

*All odds stated are subject to change without prior notice.