The 49ers prepare to hit the road this weekend to face the Jaguars. Head coach Kyle Shanahan will build on a 31-10 road win against the Rams in Week 10. Meanwhile, the hosts have plenty of ground to cover if they want to improve their 2-7 overall record. They look to bounce back from a 23-17 loss to the Colts.

That said, we share a complete preview of the 49ers vs. Jaguars game. It’s an interesting matchup as the visitors hold the upper hand coming into the game. Find the latest NFL betting odds, trends, and predictions down below. In addition, we provide team and player statistics along with event details down below.

49ers vs. Jaguars Game Information

#SFvsJAX on deck.

— San Francisco 49ers (@49ers) November 19, 2021

• When: Sunday, November 21, 2021, 1:00 PM ET
• Where: TIAA Bank Field, Jacksonville, Florida
• TV: FOX
• Radio: KNBR 680 AM (49ers) / WJXL AM 1010 (Jaguars)
• Live Stream:NFL Game Pass
• NFL Odds: 49ers (-6.0) / Jaguars (+6.0)

READ MORE: Washington vs. Panthers 2021 NFL Week 11 Odds, Preview and Pick

Why Bet on the San Francisco 49ers?

The side did well against the Rams last weekend, grabbing a 31-10 victory against the No 2. NFC West team. They completed an unanswered 14-point run in the first quarter and kept the 20-point lead until the final quarter. The 49ers produced 335 total yards by the end of the game. Overall, this brings the team’s yards per game record to 362.2 (13th).

We saw the team improve their rushing plays. The 49ers record 117.9 rushing yards (13th) per game. As for their passing game, the team averages 244.3 passing yards (13th) in nine games.

Previewing the defense, the visitors allow 23.6 points (17th) per game. They don’t do particularly well when it comes to defending rushing play. The team records 122.8 opponent rushing yards (23rd) per game. However, they hold opponents to 208.7 passing yards (sixth) per game. This is a problem for a Jaguars team that maintains mediocre passing yards per game record.

Running back Elijah Mitchell (finger) and wide receiver Deebo Samuel (knee) are on the team’s questionable list this Sunday. If the two fail to recover in time, Jeff Wilson Jr. and Trent Sherfield covers the starting positions.

Why Bet on the Jacksonville Jaguars?

The Jaguars have to start winning games if they want a shot at a postseason appearance. They secured their first two wins of the season in four games, which shows improvement. But despite that, the team has to recuperate from a 23-17 loss in Week 10.

The team holds one of the worst points per game records in the league. The Jaguars average just 16.6 points (31st) per game. They are yet to finish a game with 30 points or more this season. Offensively, they average 332.7 total yards (23rd), 119.0 rushing yards (11th), and 213.7 passing yards (24th) per game. If they want a shot at scoring in this game, head coach Urban Meyer needs to exploit the 49ers’ vulnerable rushing defense.

The Jaguars’ defense also has its struggles. The team averages 25.8 opponent points (27th) and 260.4 opponent passing yards (25th) per game. They do a little better dealing with rushing plays. The Jaguars average 106.0 opponent rushing yards (11th) per game.

Running back James Robinson is dealing with a heel injury. The starter might miss the game, along with right inside linebacker Myles Jack who is afflicted with a knee injury.

49ers vs. Jaguars Betting Trends

• The 49ers are 2-0 in the last two regular-season road games against the Jaguars (1-1 ATS).
• The 49ers are 6-4 in the last ten regular-season road games (5-5 ATS).
• The totals went under in six of the 49ers’ last ten regular-season road games.
• The Jaguars are 2-3 in the last five regular-season games at the TIAA Bank Field (2-3 ATS).
• The Jaguars held opponents to 20 points or less in two of the last five regular-season home games.
• The totals went over in four of the Jaguars’ last ten regular-season home games.

49ers vs. Jaguars Expert Betting Predictions

The 49ers enter the game in high spirits after positive results in previous games. They are the better team on paper and the favorites of the contest. There are a few rough patches, but the visitors can pressure the hosts if they start the game right. On the other hand, don’t discount the Jaguars in this one. Covering the spread is not an impossible task for the team with the numbers provided. Furthermore, the Jaguars did a few good things against the Colts in their last game.

Check out our latest sports betting guides for the 2021 NFL Regular Season. Stay tuned for more Football previews and articles and don’t forget to check out the latest Football betting odds at our online Bitcoin sportsbook.

*All odds stated are subject to change without prior notice.