There’s bound to be a huge shakeup in the Big 12 Conference after Saturday’s game from Waco. The 14th-ranked Iowa Cyclones look to keep their winning ways going and avoid their second loss of the season against the undefeated Baylor Bears, who will likely garner plenty of votes as a Top 25-worthy team with an upset of their conference rivals.

NitroBetting is ready to equip its bettors with all the latest previews and odds for Week 4 of the 2021 college football season. This time, we look at the upcoming Big 12 clash between the Iowa State Cyclones and the Baylor Bears. Find out more about the teams and the key players, event information, the latest College Football odds, and of course, helpful betting trends and expert betting predictions.

Iowa State vs. Baylor Game Information

The "heart and soul" of the team.

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— Cyclone Football (@CycloneFB) September 19, 2021

• When: Saturday, September 25, 2021, 3:30 PM ET
• Where: McLane Stadium, Waco, TX
• TV: CBS
• Radio: 95.9 KCHA (Iowa State) / ESPN 1420 (Baylor)
• Live Stream: FOX Sports Live
• College Football Odds: Iowa State (-7) / Baylor (+7)

READ MORE: Texas A&M vs Arkansas 2021 College Football Week 4 Odds and Pick

Why Bet on the Iowa State Cyclones?

Thanks to a favorable matchup against the UNLV Rebels this past week, the Iowa State Cyclones got back in the win column with an easy 48-3 victory. That win was a huge boost for Cyclones, who were outclassed by neighboring and fellow ranked program the Iowa Hawkeyes in Week 2.

Iowa State’s Heisman Trophy candidate, third-year running back Breece Hall, finally breached the 100-yard rushing mark for the first time this season in the game against UNLV with 21 carries for exactly 100 rushing yards and a pair of touchdowns. It was also the 15th straight game that Hall found the end zone, and he could set a new school record if he gets a TD against the Bears this Saturday.

Even better news for the Cyclones is that quarterback Brock Purdy got his mojo back as well, throwing for 288 passing yards and three scores against the Rebels after having no TDs and three interceptions in his first two starts. Can the dynamic duo do enough work on offense once more to put an end to Baylor’s unbeaten run?

Why Bet on the Baylor Bears?

The Baylor Bears have taken full advantage of a cakewalk schedule to start their 2021 campaign, going a perfect 3-0 and capped off by last Saturday’s 45-7 demolition of conference archenemy the Kansas Jayhawks.

Kansas is far from an elite competition, and neither were their first two opponents from mid-major conferences in Texas State and Texas Southern. Nevertheless, Baylor has outscored their first three opponents by a combined score of 140-34, with quarterback junior QB Gerry Bohanon playing lights out. Bohanon threw two passes against the Jayhawks to bring his season total to six TDs without a single pick nor sack.

He’s connected with senior wideout Abram Smith time and again, as Smith is now up to 366 receiving yards and five trips to the end zone. Baylor’s own tandem on offense appears to be just as prolific as Iowa State’s top two players mentioned earlier, but the Bears will face a true powerhouse program defense for the first time this season.

Iowa State vs. Baylor State Betting Trends

• The Cyclones are 6-2 in their last eight road games (5-3 ATS).
• The Cyclones are 3-1 in their last four meetings against Baylor, but just 1-3 against the spread.
• The totals have gone under in five of Iowa State’s last eight games away from home.
• The Bears are 8-3 at home since the start of the 2019 season (6-5 ATS).
• The Bears have lost seven straight games as underdogs, but went 4-2-1 against the spread in those contests.
• The totals have gone over in three of Baylor’s last four games played in Waco.

Iowa State vs. Baylor Expert Betting Predictions

The Cyclones have gotten the better of the Bears over the past half decade or so and still have the more talented offensive unit despite Baylor’s scoring tear over the first three weeks. Then again, the Bears are playing with much more energy and confidence than Iowa State, as well as having a decent record against the spread under most circumstances. That being said, chalk this Big 12 matchup as a more of a coin flip in terms of moneyline wagers.

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