A huge ranked-versus-ranked clash will take place in Ames this weekend, as the No. 9 Iowa State Cyclones host the No. 10 Iowa Hawkeyes. These two neighboring teams will renew their annual Cy-Hawk rivalry, with the Cyclones looking to finally break its relatively long losing spell against the Hawkeyes. Both programs are coming off victories to start the season, marking the first time that the two will meet as ranked teams in the AP polls.

NitroBetting is ready to equip its bettors with all the latest previews and odds for Week 2 of the 2021 college football season. This time, we look at the upcoming matchup between the Iowa Hawkeyes and the Iowa State Cyclones. Find out more about the teams and the key players, event information, the latest NCAAF odds, and of course, helpful betting trends and expert betting predictions. Don’t forget to check the latest 2021 College Football odds at our online Bitcoin sportsbook.

Iowa Hawkeyes vs. Iowa State Cyclones Game Information

Onto the next.

??? pic.twitter.com/Ro5pYXQAgV

— Cyclone Football (@CycloneFB) September 7, 2021

• When: Saturday, September 11, 2021, 4:30 PM ET
• Where: Jack Trice Stadium, Ames, Iowa
• TV: ABC
• Radio: AM 600 WMT (Iowa) / KASI-AM 1430 (Iowa State)
• Live Stream: WatchESPN
• College Football Odds: Iowa (+4) / Iowa State (-4)

READ MORE: Texas A&M vs. Colorado 2021 College Football Week 2 Odds and Pick

Why Bet on the Iowa Hawkeyes?

The Iowa Hawkeyes will be in a similar situation in Week 2 as with their season opener, as they’ll be facing a team that’s one rank higher than them in the polls for the second-straight week. The Hawkeyes won’t likely be fazed by this challenge, especially after their 34-6 rout of the now-unranked Indiana Hoosiers last week.

Having both a strong run offense and defense remains Iowa’s keys to success. The team ran the ball 36 times against Indiana to offset the mediocre showing of starting junior quarterback Spencer Petras (13-of-27 for 145 passing yards). Third-year running back Tyler Goodson was one-yard shy of a 100-yard rushing performance, but still found the end zone for one of the Hawkeyes’ two rushing touchdowns in Week 1.

On the other side of the ball, meanwhile, their defense was simply phenomenal, allowing just two Hoosiers field goals and with standout senior defensive back Riley Moss having two pick-sixes for a total of 85 return yards.

Why Bet on the Iowa State Cyclones?

Unfortunately for the Iowa State Cyclones, their 2021 season debut did not go entirely as planned. They had to escape with a 16-10 victory over the Northern Iowa Panthers after struggling to convert on third down, going just 5-of-14 in such situations.

On the bright side, Iowa State’s superstar running back Breece Hall still had a nice day on the ground, finishing with 69 rushing yards and a TD. Hall has a rushing touchdown in 13 consecutive games and will be the focal point of the Cyclones’ attack once more. However, they’ll need more out of quarterback Brock Purdy, who had just 199 passing yards against the Panthers despite extending his own school record of wins in Iowa State to 24 games.

Purdy will need to get the passing game going this Saturday if he wants his Cyclones to get their due revenge against a formidable Hawkeyes defense that’s held them to 17 points or fewer in each of their last two head-to-head meetings.

Iowa vs. Iowa State Betting Trends

• As mentioned earlier, the Hawkeyes are undefeated in their last five games against Iowa State (3-1-1 ATS).
• The Hawkeyes are 6-2 in regular-season road games since 2019 (5-4 ATS).
• The totals have gone under in all but one of those five most recent meetings against Iowa State.
• The Cyclones are on a six-game home win streak dating back to last October (4-2 ATS).
• On the other hand, the Cyclones are winless in their last five games against teams from the Big 10 (1-3-1 ATS).
• The totals have gone under in four out of those five matchups against Big 10 opponents.

Iowa vs. Iowa State Expert Betting Predictions

Despite having a more impressive win in Week 1, the Hawkeyes are slight underdogs to win in Ames this Saturday, perhaps because of the Cyclones’ unbeaten run at home of late. But with the Cy-Hawk Trophy having gone to Iowa for the entirety of the last half-decade, the betting lines could drastically shift in favor of the Hawkeyes in the days and hours leading up to kickoff time, meaning that any and all bets for this massive showdown should be made sooner than later.

Where to Bet On College Football with Bitcoin

College Football odds are available all year round here at Nitrobetting. Create a Nitrobetting account now to win tons of Bitcoin from the 2022 College Football offseason with our up-to-date NCAAF futures odds, as well as our special Bitcoin Squares and Picks contests throughout the upcoming regular season!

Check out our latest sports betting guides for the 2022 College Football season. Stay tuned for more football previews and articles, and don’t forget to check out the latest NCAAF betting odds at our online Bitcoin sportsbook.