The biggest surprise team in the Big Ten last season was Indiana, and this year it’s No. 10 Michigan State, which was terrible in 2020. The Spartans look to remain unbeaten as they visit the unranked Hoosiers on Saturday in a possible trap game.

Several Big Ten games are for a silly trophy and the winner of this one gets the Old Brass Spittoon. The Spartans lead the all-time series against the Hoosiers, 48-17-2, including a 22-10-1 record in Bloomington.

Last year in East Lansing, Sparty was destroyed 24-0 when it was unranked and Indiana was No. 10. The 24-point victory was the largest margin of victory for Indiana at Michigan State in the history of the rivalry, besting the previous mark of 16 (16-0) set in 1969.

Before everything else, Nitrobetting arms you with everything you need to kick things off positively. Below, we provide event details, team and player statistics, and the latest NCAAF odds. More than that, we go the extra mile and share timely betting trends and predictions that help you secure the best picks. Check out for more sports betting odds and lines, exclusively at our online Bitcoin sportsbook.

Michigan State vs. Indiana Game Information

Attack the week #RELENTLESS pic.twitter.com/56oddtoLMZ

— Michigan State Football (@MSU_Football) October 12, 2021

• When: Saturday, October 16, 2021, 12:00 PM ET
• Where: Memorial Stadium , Bloomington, Indiana
• TV: FS1
• Radio: CBS SPORTS RADIO 96.5 (Michigan State) / 100.7 The Fox (Indiana)
• Live Stream: FOX Sports Live
• College Football Odds: Michigan State Spartans (-4.5) / Indiana Hoosiers (+4.5)

Why Bet on the Michigan State Spartans?

Hoosiers QB Michael Penix Jr. completed 25-of-38 passes for 320 yards, two touchdowns and two interceptions. Receiver Ty Fryfogle had the best game of his career with 11 catches for 200 yards and two scores. Fryfogle’s 178 first-half receiving yards marked the most by a Big Ten player since 2010.

Fryfogle, the 2020 Big Ten Receiver of the Year, is still going with the 2021 Hoosiers (2-3), having caught 26 passes for 272 yards and a TD, but it’s not clear if Penix will play Saturday. Indiana has been off since a 24-0 loss to Penn State on Oct. 2 and Penix suffered a separation to the AC joint in his left shoulder. Coach Tom Allen called Penix Jr.’s availability due to the injury as “week-to-week” each Saturday. He added, “you’ll find out at kickoff.”

Penix Jr. has 939 yards, four touchdowns, seven interceptions and a 53.7% completion percentage this season. Backup Jack Tuttle eight of 18 passing for 168 yards, one touchdown and one interception. In his career (11 games), Tuttle has 564 yards, three touchdowns, two interceptions and a 57.4% completion percentage.

All three of Indiana’s losses have come to ranked teams: Iowa, Cincinnati and Penn State. The offense has disappointed overall in averaging 23.8 points with seven starters back from 2020. Saturday is homecoming in Bloomington and the Hoosiers own a 45-56-6 record on homecoming.

Why Bet on the Indiana Hoosiers?

Hoosiers QB Michael Penix Jr. completed 25-of-38 passes for 320 yards, two touchdowns and two interceptions. Receiver Ty Fryfogle had the best game of his career with 11 catches for 200 yards and two scores. Fryfogle’s 178 first-half receiving yards marked the most by a Big Ten player since 2010.

Fryfogle, the 2020 Big Ten Receiver of the Year, is still going with the 2021 Hoosiers (2-3), having caught 26 passes for 272 yards and a TD, but it’s not clear if Penix will play Saturday. Indiana has been off since a 24-0 loss to Penn State on Oct. 2 and Penix suffered a separation to the AC joint in his left shoulder. Coach Tom Allen called Penix Jr.’s availability due to the injury as “week-to-week” each Saturday. He added, “you’ll find out at kickoff.”

Penix Jr. has 939 yards, four touchdowns, seven interceptions and a 53.7% completion percentage this season. Backup Jack Tuttle eight of 18 passing for 168 yards, one touchdown and one interception. In his career (11 games), Tuttle has 564 yards, three touchdowns, two interceptions and a 57.4% completion percentage.

All three of Indiana’s losses have come to ranked teams: Iowa, Cincinnati and Penn State. The offense has disappointed overall in averaging 23.8 points with seven starters back from 2020. Saturday is homecoming in Bloomington and the Hoosiers own a 45-56-6 record on homecoming.

Michigan State vs. Indiana Expert Betting Predictions

Iowa looks to be the safer pick of the two thanks to a more consistent lineup and hole-field advantage. Both teams are coming from dominant performances, documenting over 400 total yards each. Penn State can threaten to cover the spread and even take the win if Iowa put its guards down. Having a well-balanced and methodical strategy they displayed in their previous contest can help them overcome the challenge. Ultimately, this should be an interesting matchup for football and betting fans.

Where to Bet On College Football with Bitcoin

College Football odds are available all year round here at Nitrobetting. Create a Nitrobetting account now to win tons of Bitcoin from the 2022 College Football offseason with our up-to-date NCAAF futures odds, as well as our special Bitcoin Squares and Picks contests throughout the upcoming regular season!

Check out our latest sports betting guides for the 2022 College Football season. Stay tuned for more football previews and articles, and don’t forget to check out the latest NCAAF betting odds at our online Bitcoin sportsbook.