Two of Major League Baseball’s top rivalries happen on Friday. The Philadelphia Phillies head to Atlanta to take on the Braves and the San Francisco Giants host the Los Angeles Dodgers. Saturday’s top game pits the Yankees versus the Brewers and then on Sunday the Twins take on the Guardians. See below for analysis and free picks for six of this week’s best MLB matchups.

Top MLB Betting Picks of the Week (September 12th, 2022)

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Philadelphia Phillies vs. Atlanta Braves

• When: Friday, September 16, 2022, 7:20 PM ET
• Where: Truist Park, Atlanta, GA
• TV: NBCSP, Bally Sports Southeast
• Radio: 94 WIP (Phillies) // 93.7 FM The Fan (Braves)
• Live Stream: MLB.tv
• MLB Betting Odds: TBA

The Phillies hope starter Ranger Suarez can get it done versus the Braves. Suarez has a decent 3.62 ERA. His 1.33 WHIP is on the high side. Atlanta bats .262 versus Suarez. The ATL sends ace Max Fried to the mound. Fried is 13-6 with a 2.50 ERA.

But although Fried has thrown well, the Phillies have had success versus the Braves ace. The last time Fried faced the Phillies, he allowed 3 earned runs off 9 hits in an Atlanta loss. Philadelphia can repeat the effort.

MLB Betting Pick: Phillies

Los Angeles Dodgers vs. San Francisco Giants

• When: Friday, September 16, 2022, 10:15 PM ET
• Where: Oracle Park, San Francisco, CA
• TV: Apple TV+
• Radio: Dodgers Radio AM570 (Dodgers) // KNBR 680 (Giants)
• Live Stream: MLB.tv
• MLB Betting Odds: TBA

Dodgers versus Giants on Friday could be a pitchers’ duel. LAD sends Julio Urias to the hill. Urias sports a 16-7 record and a 2.30 ERA. San Francisco counters with Logan Webb. Logan is 13-8 with a 2.88 ERA. Webb should throw well.

The Dodgers are still the play because while LAD hits .271 versus Webb, the Giants bat .198 against Julio.

MLB Betting Pick: Dodgers

Baltimore Orioles vs. Toronto Blue Jays

• When: Saturday, September 17, 2022, 3:07 PM ET
• Where: Rogers Centre, Toronto, ON
• TV: Apple TV+
• Radio: 98 Rock FM (Orioles) // SN590 (Blue Jays)
• Live Stream: MLB.tv
• MLB Betting Odds: TBA

Baltimore starter Jordan Lyles is 10-10 with a 4.62 ERA. Lyles failed in his last foray to the mound, giving up 8 earned runs in 7 hits in 3.2 innings of work versus the Boston Red Sox.

The Blue Jays go with Jose Berrios. Jose has a nice 10-5 record but his ERA is 5.07. Although overall the ERA is nothing

MLB Betting Pick: Blue Jays

New York Yankees vs. Milwaukee Brewers

• When: Saturday, September 17, 2022, 7:10 PM ET
• Where: American Family Field, Milwaukee, WI
• TV: YES, Bally Sports Wisconsin, MLBN (out-of-market only)
• Radio: WFAN 660 (Yankees) // WTMJ 620 (Brewers)
• Live Stream: MLB.tv
• MLB Betting Odds: TBA

Baltimore starter Jordan Lyles is 10-10 with a 4.62 ERA. Lyles failed in his last foray to the mound, giving up 8 earned runs in 7 hits in 3.2 innings of work versus the Boston Red Sox.

The Blue Jays go with Jose Berrios. Jose has a nice 10-5 record but his ERA is 5.07. Although overall the ERA is nothing.

MLB Betting Pick: Blue Jays

Minnesota Twins vs. Cleveland Guardians

• When: Sunday, September 19, 2022, 1:40 PM ET
• Where: Progressive Field, Cleveland, OH
• TV: Bally Sports North, Bally Sports Great Lakes
• Radio: TIBN (Twins) // WTAM 1100 (Guardians)
• Live Stream: MLB.tv
• MLB Betting Odds: TBA

Minnesota starter Joe Ryan is 10-8 with a 4.05 ERA. The last time Ryan faced Cleveland, he dominated. The Twins starter threw 6 innings and yielded a single run, a home run, from 4 hits.

Cleveland counters with Cody Morris. The Guardians starter has thrown in 2 games this season. Cleveland lost both games. Ryan and the Twins win this.

MLB Betting Pick: Twins

Seattle Mariners vs. Los Angeles Angels

• When: Sunday, September 19, 2022, 4:07 PM ET
• Where: Angel Stadium, Anaheim, CA
• TV: ROOTNW, Bally Sports West
• Radio: KIRO 710 (Mariners) // KLAA 830 (Angels)
• Live Stream: MLB.tv
• MLB Betting Odds: TBA

It’s almost unfair that Mariners starter Marco Gonzalez has a 10-13 record. Gonzalez has a decent 3.89 ERA. Gonzalez heads into this off a great outing. Marco held Atlanta to 1 earned run in 6 innings of work. The Angels plan on starting 2-6 Tucker Davidson.

The Halos have lost 2 straight when Davidson has made an appearance. Both games were versus top team Houston. Against Seattle, Davidson might have more success. The Angels manufacture a win.

MLB Betting Pick: Angels

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READ MORE: Top MLB Betting Picks of the Week (September 19th, 2022)