It’s been over a decade since two former Big 12 Conference rivals, the Nebraska Cornhuskers and the Oklahoma Sooners, collided on the gridiron to decide the conference champion of the 2010 season. The Sooners won that game and denied the Cornhuskers a shot at the Big 12 title in their final season in the conference before transferring to the Big Ten the year after. The two decorated programs will face one another in what should be an instant classic.

Nitrobetting is ready to equip its bettors with all the latest previews and odds for Week 3 of the 2021 college football season. This time, we look at the “Battle of the Big Reds” rematch between the Nebraska Cornhuskers and the Oklahoma Sooners. Find out more about the teams and the key players, event information, the latest 2021 NCAAF odds, and of course, helpful betting trends and expert betting predictions. Check the out latest 2021 College Football odds at our online Bitcoin sportsbook.

Nebraska vs. Oklahoma Game Information

• When: Saturday, September 18, 2021, 12:00 PM ET
• Where: Gaylord Family-Oklahoma Memorial Stadium, Norman, Oklahoma
• TV: FOX
• Radio: 98.1 FM (Nebraska) / 107.7 FM (Oklahoma)
• Live Stream: Fox Sports Live
• College Football Odds: Nebraska (+22.5) / Oklahoma (-22.5)

READ MORE: Fresno State vs. UCLA 2021 College Football Week 3 Odds and Pick

Why Bet on the Nebraska Cornhuskers?

After their season-opening loss to Illinois, Scott Frost and the Nebraska Cornhuskers got back on the right track with back-to-back wins against a couple of FCS teams and outscoring them by a combined margin of 80-10.

It’s been two years since Nebraska won two straight contests, with the Buffalo Bulls being the team’s latest victim by way of a 28-3 rout last weekend. Quarterback Adrian Martinez played his best game of the season, connecting on a couple of long touchdown passes to wideout Samori Toure and finishing with 296 passing yards and 112 yards on the ground.

The Huskers’ defense also got a huge boost from linebacker Luke Reimer, who racked up a new career-high 16 tackles as well as his first-ever interception. All these amazing performances from Nebraska’s top stars will need to have similar outstanding performances in Week 3 to stand a chance against a top-five program in Oklahoma. During the Frost era, the Huskers are winless in seven meetings against ranked opponents.

Why Bet on the Oklahoma Sooners?

Following a narrow five-point victory over Tulane in Week 1, the Oklahoma Sooners finally woke up in Week 2 and took their frustrations out on the poor Western Carolina Catamounts, who were on the losing end of a 76-0 shutout.

Thanks to that utter annihilation of the Catamounts, Oklahoma climbed up one rung and are now the No. 3 team in the nation after two weeks of action. Sophomore Quarterback Spencer Rattler was spectacular, going 20-of-26 for 243 passing yards and five TDs. The Sooners also piled up a whopping 278 rushing yards and five more scores through the ground.

Not to mention that they held Western Carolina to under 180 yards of total offense and forced three turnovers as well. Considering Nebraska’s lackluster showings of late against ranked programs, the Sooners should prevail over their third straight non-conference opponent to start the season before their Big 12 matchups commence starting in Week 4.

Nebraska vs. Oklahoma Betting Trends

• The Cornhuskers are 2-4 in their last six regular-season road games (SU/ATS)
• The Huskers are 0-4 in games as double-digit underdogs since 2019 (1-3 ATS).
• The totals have gone under in seven of the Huskers’ last eight road games, with the lone exception resulting in a push.
• The Sooners have only one loss over their last 20 regular-season home games, but went just 11-9 against the spread.
• The Sooners have won nine straight regular-season games as favorites in a given matchup (7-2 ATS).
• The totals have gone over in five of the Sooners’ last seven regular-season home games.

Nebraska vs. Oklahoma Expert Betting Predictions

All signs point to a gimme win for the cruising Sooners, who have outbattled the Cornhuskers in their aged rivalry despite not facing each other for over 10 years. Then again, the Huskers did just reel off two consecutive wins for the first time in what feels like forever. This gives Nebraska some added fuel to the fire that may just be enough to cover the four-touchdown spread laid against them. But with Norman being the setting of this Week 3 showdown, Oklahoma could just as easily coast to another blowout victory.

Where to Bet On College Football with Bitcoin

College Football odds are available all year round here at Nitrobetting. Create a Nitrobetting account now to win tons of Bitcoin from the 2022 College Football offseason with our up-to-date NCAAF futures odds, as well as our special Bitcoin Squares and Picks contests throughout the upcoming regular season!

Check out our latest sports betting guides for the 2022 College Football season. Stay tuned for more football previews and articles, and don’t forget to check out the latest NCAAF betting odds at our online Bitcoin sportsbook.