For the third straight year, the Green Bay Packers will visit the San Francisco 49ers in the regular season as the NFC contenders clash in the Sunday night game of Week 3. The Niners are short favorites in their home opener.

Examining the upcoming NFL games this weekend, this Packers vs. 49ers game brings plenty of thrill to the table. With that, the NitroBetting team goes the extra mile to provide you with accurate event information, team and player statistics, and the latest NFL betting odds. Additionally, we present timely betting trends and betting predictions geared to bring you closer to the best possible picks. Be sure to check the latest 2021 NFL odds at out online Bitcoin sportsbook.

Packers vs. 49ers Game Information

The #49ers have made the following roster moves.

— San Francisco 49ers (@49ers) September 22, 2021

• When: Sunday, September 26, 2021, 8:20 PM ET
• Where: Levi’s Stadium, Santa Clara, California
• TV: NBC
• Radio: WTMJ 620 (Packers) / KNBR 680 (49ers)
• Live Stream:NFL Game Pass
• NFL Odds: Green Bay Packers (+3.5) / San Francisco 49ers (-3.5)

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Why Bet on the Green Bay Packers?

This is the fourth consecutive season Green Bay has faced the 49ers in a prime-time game and the third consecutive year on the road. Since the AFL/NFL merger 1970, it is the first time the Packers have played at the 49ers in the regular season in three straight years.

Last season in Week 9, the Packers rolled at the Niners 34-17 as Aaron Rodgers threw for 305 yards and four scores. He grew up not far from San Francisco and of course starred in college at Cal in the Bay area. There was some speculation that Rodgers wanted to be traded to the 49ers this offseason. San Francisco’s QB that day was the forgettable Nick Mullens because Jimmy Garoppolo was injured. Jimmy G is healthy now and Mullens is long gone.

The head coaches of these teams are friends. Green Bay’s Matt LaFleur and San Francisco’s Kyle Shanahan were on the same offensive coaching staffs with the Texans (2008-09), Washington (2010-13) and the Falcons (2015-16), and LaFleur brought the Shanahan-style offense to Green Bay when he was hired as Packers coach in 2019.

Green Bay (1-1) is on a short week after beating the Lions 35-17 on Monday. Rodgers completed 22 of 27 passes (81.5 pct.) for 255 yards and four touchdowns with no interceptions for a 145.6 rating in last week’s win. He enters Week 3 with 416 career touchdown passes and with four more can tie Hall of Famer Dan Marino (420 touchdown passes) for the sixth-most in NFL history.

Rodgers has played the 49ers 11 times, including the postseason, and has registered a passer rating of 90-plus in 10 of those games and a passer rating of 100-plus in five contests.

The NFL’s best receiver, Davante Adams, had eight catches for 121 yards vs. the Lions but didn’t score. That likely will end here as Adams has a touchdown reception in nine consecutive games on Sunday Night Football, the longest such streak in NFL history. Adams has played in four games against the 49ers (including playoffs), averaging nine receptions, 121.5 yards and a TD per game.

Why Bet on the San Francisco 49ers?

San Francisco has started 2-0 for the third time in 10 seasons, and second under Shanahan. In each of their previous 2-0 starts – 2012 and 2019 – the 49ers advanced to the Super Bowl.

The Niners won in Philadelphia 17-11 last Sunday but lost its top three running backs, JaMycal Hasty and rookies Elijah Mitchell and Trey Sermon to injuries. As of this writing, it’s not clear if any of them will play Sunday. It sounds like Mitchell will at a minimum. Hasty will not. The team also lost starter Raheem Mostert to a season-ending knee injury in Week 1, and Jeff Wilson Jr., the team’s leading rusher from 2020, suffered a meniscus tear in the offseason.

Sunday will be the first time the 49ers have had fans in their stadium since throttling the Packers in the NFC title game following the 2019 season.

Each of the last three games between these teams (including postseason) has been decided by at least 17 points. One or both teams have scored 30-plus points in each of the last four games they have played against each other (including postseason).

Green Bay carries an eight-game primetime win streak (7-1 ATS) into this matchup, easily the longest such active streak in the league and longest since Steelers won 13 straight from 2015-18. The Pack are 5-1 SU & ATS on the road in primetime under LaFleur and went 3-0 SU & ATS on Sunday Night Football last season.

Packers vs. 49ers Betting Trends

• Packers are 5-2 ATS in their last 7 games when playing on Sunday following a Monday night game.
• Packers are 8-2 ATS in their last 10 games in September.
• The total went over in 5 of Green Bay’s last 6 games.
• 49ers are 10-25-1 ATS in their last 36 games as a favorite.
• 49ers are 2-6 ATS in their last 8 home games.
• The total went over in 9 of San Francisco’s last 12 games against Green Bay.

Packers vs. 49ers Expert Betting Predictions

Pick: Niners 30, Packers 27

Check out our latest sports betting guides for the 2021 NFL Regular Season. Stay tuned for more Football previews and articles and don’t forget to check out the latest Football betting odds at our online Bitcoin sportsbook.

*All odds stated are subject to change without prior notice.