The second of two scheduled meetings between the San Francisco 49ers and the Los Angeles Rams is just days away, as the former looks to upend its division rival yet again in their annual regular-season matchups. The 49ers are slipping in the standings, though, and the Rams are coming off their bye more refreshed and ready to put their regular-season slump against the Niners to rest.

Nitrobetting is ready to equip its bettors with the latest news, NFL betting odds, and special features for the entire duration of the 2022 NFL season. This time, let’s take a closer look at the upcoming Week 8 showdown between the Green Bay Packers and the Buffalo Bills.

Packers vs. Bills Game Information

"We know we have to be prepared for everything."@GoBonnies | #GBvsBUF

— Buffalo Bills (@BuffaloBills) October 27, 2022

• When: Sunday, October 30, 2022, 8:20 PM ET
• Where: Highmark Stadium, Orchard Park, NY
• TV: NBC
• Radio: WRNW-FM 97.3 FM (Packers) // WGR 550 (Bills)
• Live Stream: NFL Game Pass
• NFL Odds: Packers (+11) // Bills (-11)

READ MORE: Bengals vs. Browns 2022 NFL Week 8 Odds, Preview & Pick

Why Bet on the Green Bay Packers?

This looked like a possible Super Bowl preview when the schedule first came out and while Buffalo remains the Super Bowl favorite at 5-1, the Packers are a hugely disappointing 3-4.

The Packers are on their first three-game skid under Coach Matt LaFleur after a 23-21 upset at Washington last Sunday. Nursing a sore thumb and out of sync with receivers, Aaron Rodgers was 23 of 35 for 194 yards and the Packers went 0 of 6 on third down. Green Bay had just 232 total yards of offense to Washington’s 364 and lost Allen Lazard to a shoulder injury, making him the team’s third wide receiver to go down during this skid. Lazard is very much in question for this one. Through six games, Lazard has 26 catches, 340 receiving yards and four touchdowns. He trails only rookie Romeo Doubs in total targets (41). He’s catching 63.4 percent of targets and averaging 8.3 yards per target.

The offense simply looks broken. Rookie receivers Doubs and Christian Watson have not helped. Watson has missed the past two games because of a hamstring injury and has played in only four of the seven games so far. Doubs had his worst game on Sunday, failing to catch any of the four balls thrown his way.

“We scored 14 points [on offense against Washington] — seven in a two-minute [situation], seven on a short field,” Rodgers said. “Last week, we scored 10 points — three in a two-minute, seven in a no-huddle. It hasn’t been winning football on offense.”

While the last two games may have been the low points for the Packers offensively, moving the ball and putting points on the board has been a struggle all season long. Green Bay enters Week 8 ranked 23rd in points per game and 20th in total yards.

Why Bet on the Buffalo Bills?

Buffalo comes off its bye week and thus should be healthy. Under head coach Sean McDermott, the Bills are unbeaten coming off of a bye week. Since 2017, Buffalo is 5-0 after bye weeks and have wins over the Bucs, Dolphins, Chargers and more. McDermott averages 27.6 points per game, 349.8 total yards per game and has forced 10 takeaways following a bye week. Buffalo Josh Allen leads the NFL averaging 330 passing yards per game and is second with 19 total touchdowns and a 109.1 passer rating.

One interesting storyline will be the fact that the No. 1 passing offense in the NFL will be going up against the No. 1 passing defense in the league. Buffalo is averaging 323 passing yards per game, while the Packers are giving up a slim 168.9 passing yards per game. If you look at the total yardage, the Bills are averaging 440.8 yards per game (1st) and the Packers are giving up 308.4 yards per game (8th).

Buffalo Pro Bowl cornerback Tre’Davious White won’t play Sunday. White, who’s rehabbing from an ACL injury last season, was designated to return from the physically unable to perform list ahead of Week 6 and has returned to practices, but he’s yet to be activated to the 53-man roster. If the star cornerback isn’t added to the active roster ahead of Buffalo’s Nov. 6 matchup against the Jets, White would revert back to the PUP list for the remainder of the campaign.

Green Bay and Buffalo have alternated wins in the series since 1994 with each club winning four contests. Only four of the 13 previous contests in the series have been decided by single digits. Green Bay won the last matchup, a 22-0 victory at home in 2018. It will be the Packers first regular-season game at Buffalo since 2014.

Neither team has won a road game in the series since 1991, a 34-24 victory by the Bills. The Packers will be looking for their first-ever win at Buffalo. The Bills are the only team in the NFL that the Packers have not won a road game against.

Packers vs. Bills Betting Trends

• Packers are 1-4 ATS in the last 5 games following a straight up loss.
• Packers are 1-5 ATS in the last 6 games following a ATS loss.
• The total went under in 9 of Green Bay’s last 12 games played in October.
• Bills are 8-2-2 ATS in the last 12 games overall.
• Bills are 4-1-2 ATS in the last 7 games following a bye week.
• The total went under in 5 of Buffalo’s last 6 games.

Packers vs. Bills Expert Betting Predictions

Packers ATS.

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*All stated odds are subject to change without prior notice.