2021 NFL Week 16 Preview, Odds and Picks

It’s getting down to crunch time. NFL teams hoping to make the league’s postseason must step it up in Week 16. Starting on Thursday, almost over matchup has playoff implications. On Thursday, the 49ers take on the Titans. Then on Saturday, the Browns must beat the Packers in Lambeau to keep their playoff hopes alive while the scorching Colts travel to AZ to go against the floundering Cardinals. Check out the NFL odds, analysis, and free picks for 8 of NFL Week 16’s most important games.

Top 2021 NFL Week 16 Betting Picks

READ MORE: 2021 NFL Week 15 Recap

Thursday, Dec. 23

San Francisco 49ers vs. Tennessee Titans

  • 2021 NFL Week 16 Odds: San Francisco 49ers -3.5

Most NFL handicappers are all over San Francisco, and why not? The 49ers have won 2 straight and are on their way to a playoff berth. But before pounding the Niners, it’s important to realize a couple of things. First, San Francisco got lucky in their 26-23 overtime victory over the Bengals. Second, Seattle beat San Francisco a few games ago. The 49ers could be due for a letdown. Tennessee is 5-2 ATS at home. Titans can win this straight up.

NFL Week 16 Pick: Titans

Saturday, Dec. 25

Cleveland Browns vs. Green Bay Packers

  • 2021 NFL Week 16 Odds: Green Bay Packers -8

Green Bay struggled against the Baltimore Ravens, but in hindsight, we should have known Tyler Huntley would be effective. Huntley is one of the better backup quarterbacks in the league. Even if the Browns get back Baker Mayfield for this, both their starting defensive ends didn’t look good in the loss to the Raiders. Takkarist McKinley almost certainly won’t play. Myles Garrett is banged up. Green Bay should roll in this one. Expect at least a 10-point victory. A blowout win is not impossible.

NFL Week 16 Pick: Packers

Indianapolis Colts vs. Arizona Cardinals

  • 2021 NFL Week 16 Odds: Arizona Cardinals -1

Quarterback Kyler Murray has thrown 3 picks in his last couple of games. On Saturday, Murray and the Cards face the best takeaway defense in the NFL. Also, Zona’s D allowed the Lions to rush for 126 yards in the surprising Week 15 loss. Jonathan Taylor beat up the Patriots’ defense for 170 in Week 15. Colts should win this by at least a touchdown.

NFL Week 16 Pick: Colts

Sunday, Dec. 26

Buffalo Bills vs. New England Patriots

  • 2021 NFL Week 16 Odds: New England Patriots -2.5

The Bills got back on track against the terrible Carolina Panthers. It’s important to note who Buffalo played because beating the Panthers is much different than taking down the Patriots. Bill Belichick and New England should get back on track in this game. Belichick came up with the perfect plan to contain Josh Allen in the first matchup. Why wouldn’t Bill come up with the perfect plan in the second contest?

NFL Week 16 Pick: Patriots

Tampa Bay Buccaneers vs. Carolina Panthers

  • 2021 NFL Week 16 Odds: Tampa Bay Buccaneers -11

Another team that figures to get back on track in NFL Week 16 are the Tampa Bay Buccaneers. The Bucs looked horrible in the loss to the Saints. But Tampa faces a team that threw in the towel around Week 8. The Carolina Panthers might be the worst team in the NFL right now. Okay, the Jaguars are worse, but the Panthers are right there. Tampa dominates.

NFL Week 16 Pick: Buccaneers

Baltimore Ravens vs. Cincinnati Bengals

  • 2021 NFL Week 16 Odds: Cincinnati Bengals -2.5

Baltimore continues to have issues in the secondary. So even though Lamar Jackson will do his best to keep this close, Joe Burrow should light up the scoreboard. Bengals at -2.5 constitutes overlay odds. If the Ravens decide to double Ja’Marr Chase, Joe Mixon should catch the ball 10 times out of the backfield. Baltimore can’t put together two excellent performances in a row versus a couple of the league’s better quarterbacks. Bengals all the way.

NFL Week 16 Pick: Bengals

Chicago Bears vs. Seattle Seahawks

  • 2021 NFL Week 16 Odds: Seattle Seahawks -7

Chicago repeatedly shot themselves in the foot in a 17-9 loss to the Minnesota Vikings on Monday night. Simply put, Justin Fields isn’t ready to be a starter in the NFL. Expect Russell Wilson to dominate the Bears’ defense. This one should get ugly because Seattle’s defense has played well in recent weeks.

NFL Week 16 Pick: Seahawks

Monday, Dec. 27

Miami Dolphins vs. New Orleans Saints

  • 2021 NFL Week 16 Odds: New Orleans Saints -3

Oddsmakers know the Saints often bounce after big wins against the Buccaneers. Monday night could be a trouble game for New Orleans. But although Saints quarterback Taysom Hill isn’t Drew Brees, he doesn’t turn the ball over. Also, Sean Payton should be on the sidelines for this one and the Saints’ D will goad Tua into bad throw after bad throw. New Orleans is surging. The Saints should win and cover.

NFL Week 16 Pick: Saints

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*All odds stated are subject to change without prior notice.