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2021 NFL Week 3 Preview, Odds and Picks

By Hank Blaine

NFL Week 3 starts off on Thursday night when the 2-0 Carolina Panthers head to Houston to take on the 1-1 Texans. Top matchups in Week 3 include the KC Chiefs hosting the L.A. Chargers, Tampa traveling to Inglewood to take on the Rams, the Titans hosting the Colts, and the New Orleans Saints heading to the Northeast to take on the Patriots. Check out odds, analysis, and NFL Week 3 free picks! Be sure to check out the latest 2021 NFL odds and lines at our online Bitcoin sportsbook before placing your bets this season!

Top 2021 NFL Week 3 Betting Picks

READ MORE: 2021 NFL Week 2 Recap

Thursday, Sep. 23

Carolina Panthers vs. Houston Texans

  • 2021 NFL Week 3 Odds: Carolina Panthers -8

The Panthers are undefeated after 2 games. When was the last time we could say that? In any case, a question remains about whether or not Sean Payton and Jameis Winston blew the Saints chances or if the Panthers are really better than New Orleans. In any case, Tyrod Taylor is on IR, which means the Carolina rocks Houston.

NFL Week 3 Pick: Panthers

Sunday, Sep. 26

Indianapolis Colts vs. Tennessee Titans

  • 2021 NFL Week 3 Odds: Tennessee Titans -5.5

Carson Wentz sprained both his left and right ankles last Sunday. That’s bad news. Even if Wentz plays, he’ll have trouble turning his foot, which means he won’t have as much zip on the ball. Titans cover.

NFL Week 3 Pick: Titans

Los Angeles Chargers vs. Kansas City Chiefs

  • 2021 NFL Week 3 Odds: Kansas City Chiefs -6.5

At first glance, it looks as if the Chiefs should easily cover the spread. But KC is a bad covering team. Also, the Chiefs’ defense may be the worst in the NFL. Justin Herbert will light up KC’s secondary, which means the Chiefs could win while the Bolts cover.

NFL Week 3 Pick: Chargers

Atlanta Falcons vs. New York Giants

  • 2021 NFL Week 3 Odds: New York Giants -3

Atlanta played well against Tampa Bay until everything fell apart. But in no way are the Falcons a better team than the Giants. New York lost against the WFT, last season’s NFC East Division winners. The Giants should roll the ATL.

NFL Week 3 Pick: Giants

Chicago Bears vs. Cleveland Browns

  • 2021 NFL Week 2 Odds: Cleveland Browns -7

Chicago will either start a limping Andy Dalton or young Justin Fields. Either way, Cleveland has a massive edge at the quarterback position. Browns should blow past this overlay spread.

NFL Week 3 Pick: Browns

Cincinnati Bengals vs. Pittsburgh Steelers

  • 2021 NFL Week 3 Odds: Pittsburgh Steelers -4.5

Last Sunday, the Steelers bounced. Pittsburgh had no energy in a loss to the Las Vegas Raiders. Pittsburgh should show up with a lot of energy in this division game versus the rival Bengals. Cincy can hang, but the line doesn’t represent how much better the Steelers’ defense is than Cincinnati’s. Pittsburgh wins by at least 6.

NFL Week 3 Pick: Steelers

Baltimore Ravens vs. Detroit Lions

  • 2021 NFL Week 3 Odds: Baltimore Ravens -7.5

The Ravens tend to play down to their competition. Not only that, but Baltimore laid it all on the line in the victory over the Kansas City Chiefs. There’s a chance the Lions win this on the moneyline.

NFL Week 3 Pick: Eagles

New Orleans Saints vs. New England Patriots

  • 2021 NFL Week 3 Odds: New England Patriots -3

Kyler Murray and the Cardinals dominated the Tennessee Titans in their first game of the season. Let’s not read more into the victory than we should, though. The Titans had no energy in that game. Minnesota fell to the Bengals. So, it makes sense why the Cards are more than 3-point favorites. The Vikings are a solid bunch, though. Here’s another where the NFL betting line appears to stem from a week 1 overreaction.

NFL Week 3 Pick: Saints

Washington Football Team vs. Buffalo Bills

  • 2021 NFL Week 3 Odds: Buffalo Bills -8

The odds make the Bills an underlay. Buffalo jumped on the Dolphins in week 2. Tua Tagovailoa went down and the Fins never recovered. The WFT is more consistent on offense while D.C.’s defensive line should keep Josh Allen and the Bills offense somewhat contained. WFT covers.

NFL Week 3 Pick: Washington

Seattle Seahawks vs. Minnesota Vikings

  • 2021 NFL Week 3 Odds: Seattle Seahawks -2

Minnesota is a last second, missed field goal away from being 1-1. The Vikings should take this game straight up because Seattle’s defense can’t stop the run or the pass. Derrick Henry dominated the Hawks on the ground. In NFL Week 3, Seattle faces another awesome running back in Dalvin Cook. Minnesota wins this.

NFL Week 3 Pick: Vikings

Tampa Bay Buccaneers vs. Los Angeles Rams

  • 2021 NFL Week 3 Odds: Tampa Bay Buccaneers -1.5

The line opened Rams -1. In less than two days, it’s flipped so that the Buccaneers are -1.5. As good as the Rams are, they don’t have the consistency on either side of the ball to beat a team like Tampa. Not yet anyhow. Give Brady and the Bucs the nod.

NFL Week 3 Pick: Buccaneers

Monday, Sep. 27

Philadelphia Eagles vs. Dallas Cowboys

  • 2021 NFL Week 3 Odds: Dallas Cowboys -4

This is a much tougher game to handicap than many believe. Both teams have solid defenses. Both teams start decent quarterbacks. The Cowboys would be the play at -3. But the extra point is an issue. We’ll take the 4 points.

NFL Week 3 Pick: Eagles

Check out our latest sports betting guides for the 2021 NFL season. Stay tuned for more Football previews and articles and don’t forget to check out the latest Football betting odds at our online Bitcoin sportsbook.

*All odds stated are subject to change without prior notice.