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2022 NFL Week 10 Fantasy Waiver Wire Picks

By Jeff Stinger

After six teams went on bye in Week 9, Week 10 is more forgiving for fantasy managers, with only the Ravens and Bengals taking their scheduled break. Nevertheless, each week is crucial in the fantasy world, especially with the playoffs approaching ever so closer. Good thing that there will be some prominent names on this week’s waiver wires to bolster fantasy managers’ rosters as early as now.

Nitrobetting is ready to equip its bettors with the latest news, odds, and special features for the entire duration of the 2022 NFL season. This time, let’s take a closer look at the hottest waiver wire targets in fantasy football heading into Week 10.

Top Fantasy Football Waiver Wire Targets in 2022 NFL Week 10

READ MORE: 2022 NFL Week 10 Odds, Overview & Picks


Jimmy Garoppolo – 49ers

  • Pct. Owned: 18.4%

Considering that the Niners just had their bye in Week 9, there’s a great chance that Jimmy Garoppolo is on the waiver wire market heading into the new week. What’s more surprising is that the notoriously handsome gunslinger hasn’t been as terrible under center at all, be it in fantasy or real-life football.

Over his past four starts, Garoppolo averaged 17 fantasy points per game. While that number isn’t eye-popping, it’s certainly a cut above the rest of the QB free market pack right now. The 49ers will face a middle-of-the-road Chargers Defense in Week 10 and are currently (-7.0) favorites to win at home on Sunday night, which boosts Jimmy G’s value even more as a superb streaming QB option this week.

Running Back

Jeff Wilson Jr. – Dolphins

  • Pct. Owned: 44.6%

A former 49er, Jeff Wilson Jr. has found greener pastures from his solid stint in the Bay Area to his debut in South Beach this past week. Wilson split carries with his former San Fran teammate Raheem Mostert out of the Dolphins’ backfield and finished with nine carries for 51 rushing yards.

Mostert was the one who found the end zone with his nine totes against the Bears Sunday, but Wilson was the more productive back in terms of yards-per-carry (5.7 YPC). Head coach Mike McDaniel likes what he sees in his team’s backfield duo that he’s all too familiar with having been the 49ers’ OC last season himself. This makes Wilson a high-upside RB2/FLEX pickup indeed, especially if Wilson’s previous fantasy owners were quick to drop the 26-year-old back right after the Niners traded for Christian McCaffrey.

Kyren Williams – Rams

  • Pct. Owned: 14.3%

It’s hard to find quality mid-tier running backs in fantasy this season and there’s been a rising trend of managers taking a shot at fifth-round rookie Kyren Williams as a speculative stash. It’s clear that neither Darnell Henderson Jr. nor Cam Akers was the answer to the Rams’ running game woes, and this suddenly puts the fantasy spotlight on the young Notre Dame product.

An ankle injury suffered during the season opener placed Williams on the shelf and spoil his professional debut. Multiple sources are claiming that Williams’ return from the injured reserve list could happen as soon as this week. Fantasy managers in desperate need of running back depth should consider taking a flyer on the former ACC Player of the Year, who could end up being a late-season surprise and a valuable supporting piece on a playoff-bound fantasy team.

Wide Receiver

Mecole Hardman – Chiefs

  • Pct. Owned: 36.1%

Not to state the obvious, but the Chiefs’ offense is just as explosive as ever. A huge part of KC’s success can be attributed to the rise of third-year wideout Mecole Hardman, who has emerged as the heir apparent to the void left by speedy All-Pro receiver Tyreek Hill.

In Week 9, hardman set new season-highs of nine targets, six catches, and 79 receiving yards along with a trip to the end zone. Granted, KC was embroiled in an overtime battle that saw Patrick Mahomes throw over 60 passes in the contest. Then again, Hardman has sneakily been a big end-zone threat for the Chiefs, as the former second-round pick out of Georgia has a total of six TDs (four receiving, two on the ground) this season already. Better check your waiver wire still has Hardman sitting there and snag him at all costs even if it costs a hefty FAAB price for those leagues that make waiver-wire pickups more challenging.

Terrace Marshall Jr. – Panthers

  • Pct. Owned: 8.4%

Ever since P.J. Walker has been appointed the starting QB in Carolina, sophomore wide receiver Terrace Marshall Jr. has finally gotten to show what he’s made of as well. The Panthers drafted Marshall in the second round of last year’s draft and it’s only been lately that the LSU product has been involved in his team’s offense.

Marshall made his presence felt in Week 8 with nine targets, four catches, and 87 receiving yards. This past Sunday, he scored his first NFL touchdown and finished with six targets, three catches, and 53 more yards. The Panthers’ offense is still relatively inept but they’ll be facing a Falcons defense in Week 10; one that’s allowed opponents to score 20 or more points against them in all but one of their games this season. Carolina is merely a (+3.0) home dog against Atlanta in their Thursday Night Football showdown on tap.

Tight End

Cole Kmet – Bears

  • Pct. Owned: 27.0%

We’d best not miss Cole Kmet on the waiver wires this week considering that the Bears’ offense has suddenly improved of late. After putting up bagels in his first two starts of the season, Kmet is back to his high-TD-upside potential that many fantasy owners who drafted him this year had hoped for.

Kmet is available in nearly three-fourths of fantasy leagues and that won’t be the case for long. The 6-foot-6 tight end out of Notre Dame has three TDs in his last two starts and is averaging close to eight fantasy points (PPR) over his last seven games. Kmet is a low-end TE start for as long as Justin Fields continues to impress, albeit only for points-per-reception leagues as his total targets still leave a lot to be desired.

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*All stated odds are subject to change without prior notice.

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