2022 NFL Week 13 Odds, Overview & Picks

By Hank Blaine

NFL Week 13 is almost here, which means it’s time for us to check out the week’s top pro football matchups. Things kick off on Thursday when the Bills take on the Patriots. Then on Sunday, Deshaun Watson returns to lead the Cleveland Browns versus the Houston Texans and the Tennessee Titans take to the gridiron to throw down against the Philadelphia Eagles.

Check out the latest NFL odds, analysis, and free picks for eight of the best games happening in NFL Week 13.

Top 2022 NFL Week 13 Games to Bet

READ MORE: 2022 NFL Week 13 Fantasy Waiver Wire Picks

Buffalo Bills vs. New England Patriots

  • When: Thursday, December 1st, 2022. 8:15pm EST.
  • Where: Gillete Stadium, Foxborough, MA
  • NFL Odds: Bills (-3.5) // Patriots (+3.5)

This is an important game for both teams. The Bills are 8-3 straight up and tied with Miami for first place in the AFC East. The Patriots are two games behind at 6-5.

Buffalo remains one of the better teams in the league, but the Bills are just 5-5-1 against the spread. More importantly, they’ve gone 1-4 ATS in their last 5. So taking the points on New England makes sense.

2022 NFL Week 13 Pick: New England Patriots

Cleveland Browns vs. Houston Texans

  • When: Sunday, December 4th, 2022. 1:00pm EST.
  • Where: NRG Stadium, Houston, TX
  • NFL Odds: Bills (-7) // Patriots (+7)

Most expect Deshaun to start against the Texans. All indications are Watson has looked great in practice.

Houston shouldn’t keep up versus a Deshaun Watson led offense. The Texans have gone 1-5 ATS in their last 6 and have scored under 17 points in 4-of-5. Cleveland should roll to an easy win and cover.

2022 NFL Week 13 Pick: Cleveland Browns

Washington Commanders vs. New York Giants

  • When: Sunday, December 4th, 2022. 1:00pm EST.
  • Where: NRG Stadium, Houston, TX
  • NFL Odds: Commanders (-7) // Giants (+7)

The Giants hope to end a 2-game losing streak when NYG hosts NFC East rival Washington. Beating D.C. won’t be easy.

Washington has won 5-of-6 straight up. 1 of the victories includes handing the Eagles their first loss of the season. Not only that, but D.C. is the hottest team in the NFL against the spread, going 6-0-1 ATS in their last 7. The road team gets the nod.

2022 NFL Week 13 Pick: Washington Commanders

New York Jets vs. Minnesota Vikings

  • When: Sunday, December 4th, 2022. 1:00pm EST.
  • Where: U.S. Bank Stadium, Minneapolis, MN
  • NFL Odds: Jets (+3) // Vikings (-3)

The Jets switched quarterbacks from Zach Wilson to Mike White and it turned out to be the right move. White went 22-of-28 for 315 yards and threw 3 TD passes in a win against Chicago.

No doubt that after the scintillating performance, Wilson is on the trading block. The Vikings played well on Thanksgiving night versus New England but the Jets’ offense has more weapons. If White plays versus Minny the way he did against Chicago, NYJ should win again.

2022 NFL Week 13 Pick: New York Jets

Tennessee Titans vs. Philadelphia Eagles

  • When: Sunday, December 4th, 2022. 1:00pm EST.
  • Where: Lincoln Financial Field, Philadelphia, PA
  • NFL Odds: Titans (+5) // Eagles (-5)

Philly shows a single straight up loss on the record but against the spread, the Eagles have struggled going 1-3 ATS in their last 4.

Tennessee lost to Cincinnati in a home game as a 1-point underdog in their last. Before the week 12 loss, the Titans had gone 7-1 SU and 8-0 against the spread. The 6.5 points make the road team an overlay.

2022 NFL Week 13 Pick: Tennessee Titans

Tennessee Titans vs. Philadelphia Eagles

  • When: Sunday, December 4th, 2022. 1:00pm EST.
  • Where: Lincoln Financial Field, Philadelphia, PA
  • NFL Odds: Titans (+5) // Eagles (-5)

Philly shows a single straight up loss on the record but against the spread, the Eagles have struggled going 1-3 ATS in their last 4.

Tennessee lost to Cincinnati in a home game as a 1-point underdog in their last. Before the week 12 loss, the Titans had gone 7-1 SU and 8-0 against the spread. The 6.5 points make the road team an overlay.

2022 NFL Week 13 Pick: Tennessee Titans

Miami Dolphins vs. San Francisco 49ers

  • When: Sunday, December 4th, 2022. 4:05pm EST.
  • Where: Levi’s Stadium, Santa Clara, CA
  • NFL Odds: Dolphins (+5) // 49ers (-5)

Fins versus Niners could be a prelude to this season’s Super Bowl. Like in 1984, Dan Marino’s rookie year with the Dolphins, the 49ers have a great defense and the Fins boast a terrific offense.

SF is rolling with 4 straight victories and a 3-1 spread line record in their last four. Miami has won 5 straight and has also gone 3-1 against the spread in their last 4. SF’s defense is good enough to contain Tua and Miami’s offense. But 4.5 points are too many to give up. Miami is the play.

2022 NFL Week 13 Pick: Miami Dolphins

Los Angeles Chargers vs. Las Vegas Raiders

  • When: Sunday, December 4th, 2022. 4:25pm EST.
  • Where: Allegiant Stadium, Paradise, NV
  • NFL Odds: Chargers (-1) // Raiders (+1)

The Raiders have won two straight both SU and ATS. The 22-16 overtime victory against Denver was nice but the 40-34 win against Seattle impressed more.

The Los Angeles Chargers are 2-2 straight up in their last four but have gone 3-1 ATS. Also, the Raiders should be gassed in the fourth quarter after two straight overtime games.

2022 NFL Week 13 Pick: Los Angeles Chargers

Kansas City Chiefs vs. Cincinnati Bengals

  • When: Sunday, December 4th, 2022. 4:25pm EST.
  • Where: FirstEnergy Stadium, Cleveland, OH
  • NFL Odds: Chiefs (-1) // Bengals (+1)

Chiefs versus Bengals is a rematch of last season’s AFC Championship. Kansas City heads into the game after going 1-5-1 ATS in their last 7.

The Bengals are on fire. Cincinnati has won 7-of-9 and have gone 8-1 ATS. Considering KC’s spread line record, the Bengals are an easy pick. Back Cincinnati to cash.

2022 NFL Week 13 Pick: Cincinnati Bengals

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*All stated odds are subject to change without prior notice.