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2022 NFL Week 16 Odds, Overview & Picks

By Hank Blaine

Because Christmas falls on a Sunday this year, the National Football League will play most of their NFL Week 16 games on Saturday, Dec. 24. On Saturday, the scorching Bengals travel to New England a road favorite versus the Patriots. New England must win to keep their playoff hopes alive.

Check out the latest NFL odds, analysis, and free picks for the best games happening in NFL Week 16.

Top 2022 NFL Week 16 Games to Bet

READ MORE: 2022 NFL Week 16 Fantasy Waiver Wire Picks

Jacksonville Jaguars vs. New York Jets

  • When: Thursday, December 22nd, 2022. 8:15pm EST.
  • Where: MetLife Stadium, East Rutherford, NJ
  • NFL Odds: Jaguars (+1) // Jets (-1)

Jacksonville played great when beating the Dallas Cowboys in a stunning walk off overtime victory. But although the Jags played fantastic football to beat Dallas, the situation changes on Thursday.

The Jags hosted the Boys at home. On Dec. 22, Trevor Lawrence and Jacksonville’s offense face one of the league’s top defenses. The Jets’ should handle Trevor and his mates.

2022 NFL Week 16 Pick: New York Jets

New Orleans Saints vs. Cleveland Browns

  • When: Saturday, December 24th, 2022. 1:00pm EST.
  • Where: FirstEnergy Stadium, Cleveland, OH
  • NFL Odds: Saints (+3) // Browns (-3)

Everybody is dumping on the Browns, which sort of makes sense because Cleveland beat the Baltimore Ravens in NFL Week 15.

On the other hand, the Saints’ beat the Falcons in their last game. Ah, but New Orleans ranks twenty-third against the rush. Browns’ RB1 Nick Chubb should dominate. Cleveland wins and covers.

2022 NFL Week 16 Pick: Cleveland Browns

Seattle Seahawks vs. Kansas City Chiefs

  • When: Saturday, December 24th, 2022. 1:00pm EST.
  • Where: GEHA Field at Arrowhead Stadium, Kansas City, MO
  • NFL Odds: Seahawks (+9.5) // Chiefs (-9.5)

The only stat we’re looking at when it comes to this game is Kansas City against the spread. The Chiefs have a fantastic moneyline record. Their record against the spread leaves much to be desired.

KC is 3-10-1 ATS overall this season. Kansas City is 0-5-1 ATS at home. Seattle gets the nod.

2022 NFL Week 16 Pick: Seattle Seahawks

New York Giants vs. Minnesota Vikings

  • When: Saturday, December 24th, 2022. 1:00pm EST.
  • Where: U.S. Bank Stadium, Minneapolis, MN
  • NFL Odds: Giants (+3) // Vikings (-3)

The Giants played a fantastic game when beating the Washington Commanders 20-12 in NFL Week 14’s Sunday night matchup. To be fair, D.C. did get hosed on the last play of the game. No doubt, that was pass interference.

In any case, the Giants head to Minnesota to take on a Vikings team that beat the Indianapolis colts 39-36 in OT after falling behind 33-0. Minnesota should use momentum from that victory to win and cover in this.

2022 NFL Week 16 Pick: Minnesota Vikings

Cincinnati Bengals vs. New England Patriots

  • When: Saturday, December 24th, 2022. 1:00pm EST.
  • Where: Gillette Stadium, Foxborough, MA
  • NFL Odds: Bengals (-3.5) // Patriots (+3.5)

New England blew a late game lead versus the Las Vegas Raiders in their last, which is why the Pats are in desperation mode. Another loss sends the Patriots to 7-8, which would make it very difficult to make the playoffs.

Unfortunately for Bill Belichick’s squad, the Pats face the hottest team in the NFL. The Bengals are 9-1 SU and ATS in their last 10. Cincinnati has gone 6-0 straight up and against the spread in their last 6. On Saturday, the Bengals make it 7 straight.

2022 NFL Week 16 Pick: Cincinnati Bengals

Philadelphia Eagles vs. Dallas Cowboys

  • When: Saturday, December 24th, 2022. 4:25pm EST.
  • Where: AT&T Stadium, Arlington, TX
  • NFL Odds: Eagles (+5.5) // Cowboys (-5.5)

The Boys are the big time chalk because Eagles’ starting quarterback Jalen Hurts has a sprained shoulder. Hurts won’t play in this game.

Back up Gardner Minshew knows how to run the offense. Not only that, but Big D hosts Philly almost a week after blowing a game versus Jacksonville. The Eagles may not win with Minshew under center. They should keep it closer than the spread.

2022 NFL Week 16 Pick: Philadelphia Eagles

Tampa Bay Buccaneers vs. Arizona Cardinals

  • When: Sunday, December 25th, 2022. 4:25pm EST.
  • Where: State Farm Stadium, Glendale, AZ
  • NFL Odds: Buccaneers (-6.5) // Cardinals (+6.5)

Arizona is a lousy team. The Cards couldn’t hang with the Denver Broncos and backup quarterback Brett Rypien, losing 24-15.

Tampa has had problems this season, but the Cards should have no shot in this. Brady and his mates get it done SU and ATS.

2022 NFL Week 16 Pick: Tampa Bay Buccaneers

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*All stated odds are subject to change without prior notice.

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