Cardinals vs. Browns 2021 NFL Week 6 Odds, Analysis and Prediction

By Carlos Chacon • October 13, 2021

The only undefeated team in the season heads to Ohio to face the Cleveland Browns. In this Cardinals vs. Browns matchup, we might see the visitors get a run for their money now that the Browns picked up some pace along the way.

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Cardinals vs. Browns Game Information

When: Sunday, October 17, 2021, 4:05 PM ET
Where: FirstEnergy Stadium, Cleveland, Ohio
TV: CBS
Radio: Arizona Sports 98.7 FM (Cardinals) / ESPN WKNR 850 AM (Browns)
Live Stream:NFL Game Pass
NFL Odds: Arizona Cardinals (+2.5) / Cleveland Browns (-2.5)

Why Bet on the Arizona Cardinals?

The Cardinals are coming off their lowest-scoring game of the season after a 17-10 victory over the 49ers. It’s also the first game of the season where the team scored less than 30 points. Nevertheless, positive results came out of the performance and a tighter grip on the NFC West’s top spot.

Kyler Murray recorded 239 yards on 22-of-31 passing, including a touchdown. It was an encouraging game for the quarterback. He enjoyed the services of wide receiver DeAndre Hopkins, who led the team with 87 receiving yards and a touchdown on 6 receptions. He was the only player to score a receiving touchdown, enough to keep the Cardinals’ lead. Moreover, Rondale Moore had a team-high 38 rushing yards on 3 carries, while James Conner produced the only rushing touchdown of the side after 29 yards on 10 carries.

Examining how the team fared on defense, Jalen Thompson took charge and collected 6 solo tackles. Bodda Baker pursued him in second with 6 tackles (5 solo) and the only defensive interception of the Cardinals. Zach Allen had 4 solo tackles and the only solo sack of the side, while Isaiah Simmons and Tanner Vallejo shared a sack assist while the former found 2 solo tackles during his stint.

It’s going to be a challenging afternoon for the Cardinals with two starters on the questionable list. Rodney Hudson suffers from a rib injury, which puts Max Garcia on the spot if the starting center fails to return once again. Additionally, left cornerback Byron Murphy Jr. is still out with a rib injury he sustained against the Rams. That said, we expect Anthonio Hamilton to take over the position on Sunday afternoon.

Why Bet on the Cleveland Browns?

At the other end of the spectrum, the Browns are coming off a nail-biter clash against the Chargers in Week 5. Despite falling 6 points short of a victory, there are multiple takeaways the team can bring into this weekend’s game.

Baker Mayfield had his work cut out for him after recording 305 yards on 23-of-32 passing. The star quarterback scored 2 touchdowns for the team and helped keep the scoreline close. David Njoku had a commanding game with 149 yards and a touchdown on 7 receptions while Rashard Higgins crossed the end zone once after 29 yards and 3 receptions.

The Browns excelled in their rushing plays. Nick Chubb led the pack and ran 161 of Cleveland’s 230 rushing total yards. On top of that, the running back produced a touchdown after 21 carries. In addition, Kareem Hunt had a spectacular night following 61 rushing yards and 2 touchdowns on 12 carries.

Andraez Williams worked his way to 10 tackles (7 solo). The duo of A.J. Green and Troy Hill had 5 tackles (4 solo) each, while John Johnson had 4 solo tackles. Myles Garrett sacked the Rams’ quarterback and collected 2 tackles along the way, and at the same time, Malik McDowell earned a sack and a solo tackle. The squad had no defensive interceptions but managed to force the Rams to 1 turnover.

Head coach Kevin Stefanski will have to plug the holes and keep the core lineup competitive since multiple injuries threaten to hold the Browns back this weekend. We begin with the defensive unit, which might not have the services of Jadeveon Clowney, Denzel Ward, and Greg Newsome II. All three players are nursing injuries and listed as questionable for Sunday’s contest. Meanwhile, left tackle Jedrick Wills Jr. did not participate in practice due to an ankle injury.

Cardinals vs. Browns Betting Trends

The Cardinals are 5-1 in their last 6 games against the Browns.
The Cardinals are 4-2 against the spread in their last 6 games against the Browns.
The totals have gone over in 2 of the Cardinals’ last 5 games.
The Browns are 8-2 in their last 10 home games.
The Browns are 2-3 against the spread in their last 5 home games.
The totals have gone under in 5 of the Browns’ last 10 games.

Cardinals vs. Browns Expert Betting Predictions

This is one of the Cardinals’ tougher tests to date, but we expect the squad to keep things close despite being the slight underdogs. They have been stellar in every major offensive category and are on a three-game road streak this season. However, the Browns caught the eye of many this season, and they’re one of the best rushing teams in the league right now. They have the tools to take this one home, but the Cardinals can easily cover the spread and take the victory if they take their eye off the ball. At length, we prepare for a heated skirmish from start to end.

Check out our latest sports betting guides for the 2021 NFL Regular Season. Stay tuned for more Football previews and articles and don’t forget to check out the latest Football betting odds at our online Bitcoin sportsbook.

*All odds stated are subject to change without prior notice.