Cardinals vs. Titans 2021 NFL Week 1 Odds, Preview and Pick

By Carlos Chacon • September 7, 2021

This weekend, the NFL returns to bring us much-awaited action. Among the list of games is a contest between the Pittsburgh Steelers and the Buffalo Bills. The Steelers are coming off a 12-4 record last season, claiming the top spot in the AFC North. During the preseason, the team performed wonderfully as well, ending their run with 3 wins and one loss.

Meanwhile, the Bills finished a strong run in their previous campaign with a 13-3 record and a first-place finish in the AFC East. Looking at their preseason run, the Bills also stood out with an undefeated 3-0 run.

As another football season unfolds before us, NitroBetting graces you with the latest NFL previews. Find the latest event information, key team and player stats, and the latest NFL betting odds. More than that, we make sure you lock in on the best picks with the aid of our latest betting trends and expert betting predictions. Be sure to check out the latest 2021 NFL Season odds at out online Bitcoin sportsbook.

Cardinals vs. Titans Game Information

QB Ryan Tannehill, who was activated from the Reserve/COVID-19 list, was back on the practice field today.

Monday Quick Hits ? » https://t.co/6IQ9OAy4zp
— Tennessee Titans (@Titans) September 6, 2021

When: Sunday, September 12, 2021, 1:00 PM ET
Where: Nissan Stadium, Nashville, Tennessee
TV: CBS
Radio: 98.7 FM (Cardinals) / 104.5 FM The Zone (Titans)
Live Stream:NFL Game Pass
NFL Odds: Cardinals (+3.5) / Titans (-3.5)

Why Bet on the Arizona Cardinals?

Thanks to a very active preseason, the Arizona Cardinals have emerged as a dark horse playoff contender this 2021 NFL regular season. However, there are plenty of mouths to feed over in the crowded NFC West and the Cardinals are still considered to be at the bottom of the pecking order.

Thankfully, the Cards will not face a division rival immediately on opening week. On the other hand, a date against the mighty Titans may send the team off on the back foot to kick start their campaign. Nevertheless, Kyler Murray should be happy with his supporting cast as he continues to evolve into one of the best dual-threat quarterbacks in the league.

Arizona acquired former Bengals Pro Bowl receiver A.J. Green in the offseason to give Murray even more options outside of elite wideout DeAndre Hopkins. Signing two-time Defensive Player of the Year J.J. Watt and drafting stud linebacker Zaven Collins also boosted a Cards defense that gave up six 100-yard rushing performances from opposing running backs over the last seven weeks of the previous season.

Why Bet on the Tennessee Titans?

Over in the AFC, the Tennessee Titans have become a household name in the conference after back-to-back postseason appearances and with a deep run in the playoffs in 2019. And while the Titans have seemingly taken two steps forward and one step back since that banner 2019 campaign, they remain one of the NFL teams expected to excel this upcoming season.

A year after veteran quarterback Ryan Tannehill won the Comeback Player of the Year award, his fellow teammate Derrick Henry would then win Offensive Player of the Year honors in 2020. Henry became just the eighth player in NFL history to breach the 2,000 yards rushing mark at the end of the regular season and his job will be made easier with a huge addition to Tennessee’s receiving corps.

The team signed five-time All-Pro wideout Julio Jones from Atlanta to alleviate the pressure from Henry and the running game. The Cardinals mostly addressed defensive concerns in their front seven, and not so much their secondary, which might be in for a long afternoon against the Titans’ new-look aerial attack with Jones opposite of another receiving stud in A.J. Brown.

Cardinals vs. Titans Betting Trends

The Cardinals are 3-1 against Tennessee since the turn of the millennium (4-0 ATS).
The Cards went an even 4-4 on the road last season (SU/ATS).
The totals have gone under in all but one of those eight road games from 2020.
The Titans went 5-3 at home last season (4-4 ATS).
The Titans are 9-3 against teams from the NFC since 2018 (7-5 ATS).
The totals have gone over in six of the Titans’ last seven games against NFC opponents.

Cardinals vs. Titans Expert Betting Predictions

A matchup between Arizona and Tennessee is a rare occurrence, making this Week 1 contest much tougher to predict. Both teams have also made significant upgrades in the offseason to keep them on an even playing field. The Titans’ home-field advantage could be a huge factor in this game but they were also far from invincible at home last season. That being said, consider this inter-conference clash a virtual coin toss with two prolific offenses each looking to gun their way to victory.

Check out our latest sports betting guides for the 2021 NFL Regular Season. Stay tuned for more Football previews and articles and don’t forget to check out the latest Football betting odds at our online Bitcoin sportsbook.

*All odds stated are subject to change without prior notice.