Clemson vs. Wake Forest 2022 College Football Week 4 Odds, Preview & Pick

By Hank Blaine

On Saturday, fifth ranked Clemson puts their undefeated record on the line when the Tigers head to rival Wake Forest to take on the 18-ranked Demon Deacons. Clemson has played well this season, but Wake is last season’s ACC runner up. Will the Deacons cover the spread as a home dog? Or will Clemson show why so many believe a College Football Playoff berth is in their future?

Before everything else, NitroBetting arms you with everything you need to kick things off on a positive note. Below, we provide event details, team and player statistics, and the latest NCAAF odds. More than that, we go the extra mile and share timely betting trends and predictions that help you secure the best picks. Check out for more sports betting odds and lines, exclusively at our online Bitcoin sportsbook.

Clemson vs. Wake Forest Game Information

  • When: Saturday, September 24, 2022, 3:30 PM ET
  • Where: Truist Field, Winston-Salem, NC
  • TV: ABC
  • Radio: WCCP 105.5 FM The Roar (Clemson) // WBRF 98.1 FM (Wake Forest)
  • Live Stream: ESPN+
  • College Footall Odds: Clemson (-7) // Wake Forest (+7)

READ MORE: Florida vs. Tennessee 2022 College Football Week 4 Odds, Preview & Pick

Why Bet on the Clemson Tigers?

Last season, Clemson’s offense struggled in the early going. Not this season. The Tigers average 41.3 points per game from 425 total yards. Quarterback D.J. Uiagalelei has shown mass improvement. Uiagalelei has a TD-to-INT ratio of 5-to-1. If Uiagalelei continues his forward trajectory, the Tigers’ offense should play even better as the season continues.

Like football fans expected, Clemson’s defense has proven to be one of the best in the nation. The Tigers yield an average of 14 points per game. Opponents rush for less than 78 yards per contest. In 3 games, the Tigers have forced 5 turnovers.

Why Bet on the Wake Forest Deacon Demons?

Wake Forest quarterback Sam Hartman, a preseason Heisman Trophy contender, hasn’t disappointed. Hartman has thrown for 625 yards and 7 touchdowns to just 2 picks. One of the reasons Hartman has played so effectively this season is because he can rely on a strong rushing attack. The Demon Deacons average 128 yards per game. Wake Forest averages 42 points per.

Last season, Wake Forest’s Achilles Heel was their defense. So far in 2022, the Demon Deacons have played much better defense than they did in 2021. Opponents average 23.7 points per game versus Wake Forest’s D. The Deacons allow 192 passing yards. Teams average 125 rushing yards each game versus Wake Forest.

Clemson vs. Wake Forest Betting Trends

  • Tigers are 4-0 ATS in the last 4 on the road.
  • Clemson is 1-9 ATS in the last 10 games in September.
  • Under is 5-1 in Clemson’s last 6 on the road.
  • Demon Deacons are 7-3-1 ATS in the last 11 meetings at home.
  • Wake Forest is 1-4 ATS in the last 5 following a straight up win.
  • Over is 7-2 in Wake Forest’s last 9 versus a team with a winning record.

Clemson vs. Wake Forest Expert Betting Predictions

Neither Clemson nor Wake Forest have played a team college football fans would consider elite. Wake Forest’s three wins were against VMI, Vanderbilt, and Liberty. Clemson has beaten Georgia Tech, Furman, and Louisiana Tech. Because neither team has played a strong opponent, it’s difficult to know if their previous performances are mirages. One thing we do know is that Clemson doesn’t always step it up in September. The Tigers are a terrible 1-9 ATS in their last 10 September games.

We also know that this happens on Wake’s turf and that Clemson’s vaunted defense allowed G-Tech to score 10, Furman score 12, and Lousiana Tech post 20. Allowing bad teams to score isn’t a good sign heading into a battle against Wake Forest. Hartman is one of the better quarterbacks in the nation. He should do more than enough for Wake to keep this closer than the spread. Wake Forest covers.

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Check out our latest sports betting guides for the 2022 College Football season. Stay tuned for more football previews and articles and don’t forget to check out the latest NCAAF betting odds at our online Bitcoin sportsbook.

*All stated odds are subject to change without prior notice.