Colts vs. Bills 2021 NFL Week 11 Odds, Analysis and Prediction

By Carlos Chacon • November 16, 2021

The Indianapolis Colts and the Buffalo Bills square off in Week 11. We’re past the halfway mark of the season and both teams will try to improve, if not hold, their record for a place in the postseason. The visitors try to build on a two-game winning streak. Meanwhile, the hosts return home from a convincing win against the Jets.

NitroBetting brings you the hottest NFL previews this week, including the upcoming Colts vs. Bills game. Find all the information you need below. From event details, team and player statistics, and the latest NFL betting odds, we have everything you need. Furthermore, we provide timely betting trends and expert betting predictions that help you lock in on the best picks. Check out the latest sports betting odds and lines at our online Bitcoin sportsbook.

Colts vs. Bills Game Information

We’ve activated QB Mitch Trubisky from the Reserve/Covid-19 list.

WR Austin Proehl has been released from the practice squad. #BillsMafia pic.twitter.com/RnVkwaFWXU
— Buffalo Bills (@BuffaloBills) November 15, 2021

When: Sunday, November 21, 2021, 1:00 PM ET
Where: Highmark Stadium, Orchard Park, New York
TV: CBS
Radio: WFNI 107.5 FM (Colts) / WGR 550 (Bills)
Live Stream:NFL Game Pass
NFL Odds: Colts (+6.5) / Bills (-6.5)

Why Bet on the Indianapolis Colts?

The Colts currently hold second place in the AFC South division. It took a few weeks before the team found its stride. In their last seven games, they managed to secure five wins. However, there’s work to be done if the Colts want to improve their 2-2 road record this season.

The side managed to win by double-digits in their two road wins. It puts less pressure on the team knowing that they can deliver good results in uncharted territory. As a team, they record 371.0 (12th) total yards and allow 367.2 opponent yards (20th) per game.

Despite not having the best passing statistics and only average 233.7 passing yards per game, the Colts manage to find their stride on the rushing side. It is one of the stronger areas of their offense. They average 137.3 rushing yards per game (fifth).

Defensively, the Colts have to improve their numbers if they want to put pressure on the Bills this weekend. The team allows 260.8 passing yards (23rd) per game. Moreover, the Colts have to work on defending rushing plays better as they take on a team that executes rushing plays well. They currently allow 106.4 rushing yards (13th) per game.

We expect the Colts to come in with a healthy starting lineup. Only right cornerback Xavier Rhodes remains out of the list following a calf injury.

Why Bet on the Buffalo Bills?

The Bills demolished the Jets in a 45-17 victory in Week 10. What gives the home team confidence is that they only lost a game in four road contests. A win gives more breathing room from a Patriots team breathing down their necks in the AFC East division.

The hosts have one of the most impressive statistics in the league right now. They feature a well-balanced offense and defense. The side averages 390.1 yards (eighth) and 270.4 passing yards (seventh) per game. Rushing is not the team’s forte, but they do enough to record 119.8 rushing yards (11th) in nine games.

Defense is where the Bills shine the most. We can argue that they are the best defensive team in the league right now. The team limits opponents to 262.6 yards (first) and 177.0 passing yards (first) per game. On top of that, they hold teams to 85.6 rushing yards per game (fourth).

Two defensive players will sit the game out. Right defensive tackle Star Lotuleilei and middle linebacker Tremaine Edmunds are out with injuries.

Colts vs. Bills Betting Trends

The Colts are 3-3 in the last six regular-season road games against the Bills (3-4 ATS).
The Colts are 6-4 in the last ten regular-season road games (7-3 ATS).
The totals went over in five of the Colts’ last six regular-season games.
The Bills are 7-3 in the last ten regular-season home games against the Colts (6-4 ATS).
The Bills are 6-4 in the last ten regular-season home games (4-6 ATS).
The totals went under in five of the Bills’ last ten regular-season games at the Highmark Stadium.

Colts vs. Bills Expert Betting Predictions

The Bills hold a significant advantage over the two in this matchup. Having the home-field advantage and a better overall record makes them favorites in the game. There’s no arguing that head coach Sean McDermott does an excellent job making the team Super Bowl LVI contenders.

On the other hand, the Colts can put pressure on the home team. This is their chance to gain some momentum on the road before Week 12. Covering the spread should be doable for the team. If everything falls in place for the Bills, we might even see the team go for the win this Sunday.

Check out our latest sports betting guides for the 2021 NFL Regular Season. Stay tuned for more Football previews and articles and don’t forget to check out the latest Football betting odds at our online Bitcoin sportsbook.

*All odds stated are subject to change without prior notice.