This year’s final March Madness Sweet 16 game tips-off at 9:59 pm ET in Chicago on Friday night when 10-seed Miami takes on 11-seed Iowa State. The winner goes against the Providence versus Kansas winner on Sunday. Miami has proven they’re a legit ACC power. Iowa State has shown they’re for real. Which Cinderella continues to wear the glass slipper?

Before all else, Nitrobetting takes a peek at important game details that help you lock in on the best picks. Below, you can find event information, team and player stats, and the latest College Basketball odds. We also have timely betting trends and predictions at your disposal.

Iowa State vs. Miami (FL) 2022 March Madness Sweet 16 Game Information

Sweet Sixteen bound ? pic.twitter.com/gUPpsjc164

— Canes Hoops (@CanesHoops) March 23, 2022

• When: Friday, March 25, 2022, 9:29 PM ET
• Where:United Center, Chicago, IL
• TV: TBS
• Radio: KCCQ-FM 105.1 (Iowa State) / 560 WQAM-AM (Miami)
• Live Stream: March Madness Live
• NCAAB Betting Odds: iowa State (+2) / Miami (-2)

READ MORE: Providence vs. Kansas NCAAB Odds and Preview – March 25th, 2022

Why Bet on the Iowa State Cyclones?

Most regard the Big 12 as this season’s best men’s college basketball conference. Although Baylor fell to North Carolina in their second round game, Kansas, Texas Tech, and Iowa State all made the Sweet 16. The Cyclones didn’t end their season on a high note. But so far in the tournament, they’ve rocked it. The Cyclones’ defense allowed LSU to score just 54 points. Then versus highly-regarded Wisconsin, Iowa State held the Badgers to 49 points. Miami should have a tough time breaking down the Cyclones’ defense.

Why Bet on the Miami Hurricanes?

Before the tournament tipped, most college basketball fans though it was a down year for the ACC. It turns out, the ACC is just as dominant as it’s always been. North Carolina, Duke, and Miami are all in the Sweet 16. Miami finished the regular season with a 22-9 record, third best in the conference behind the Blue Devils and Tar Heels. The Hurricanes outlasted USC in the first round and then blew out 2-seed Auburn in the second. Miami is getting better with each game. Iowa State will find it difficult to contain all of Miami’s shooters.

Iowa State vs. Miami (FL) Betting Trends

• Cyclones are 6-1 ATS in their last 7 neutral site games as an underdog.
• Iowa State is 5-1 ATS in their last 6 games as an underdog.
• Under is 4-0 in the Cyclones’ last 4 neutral site games.
• Hurricanes are 6-1-1 ATS in their last 8 games.
• Miami is 3-1-1 ATS in their last 5 games following an ATS win.
• Over is 4-0 in the Hurricanes’ last 4 games as a favorite.

Iowa State vs. Miami (FL) Expert Betting Predictions

The spread line says this is a close game. But after much handicapping, it’s difficult to make a case for the Cyclones. Yes, Iowa State held Wisconsin to 49 points. However, the Badgers shoot less than 42% from the field and less than 32% from three on average. Also, Wisconsin is a one-man team. If you stop, or even just contain, Jonathan Davis, you can beat Wisconsin. Davis scored 17 against the Cyclones. That wasn’t nearly enough.

In Iowa State’s first NCAA Tournament game, they beat an overrated LSU squad. The entire SEC is overrated. Only Arkansas made it to the Sweet 16. So Iowa State beat a couple of teams that the Selection Committee gave too much respect while Miami dropped the third-best team in the Pac-12, USC, and dominated the best team or second-best team from the SEC, Auburn. Not only that, but the Hurricanes beat a couple of Sweet 16 teams this season, Duke on the road 76-74 and North Carolina at home 85-57. The Canes should roll the Cyclones. The -2.5 makes Miami an overlay.

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This is just one of the many sports betting guides that you can read here at Nitrobetting news. Stay tuned for more 2021-22 NCAAB season previews and articles, and don’t forget to check out the latest college basketball odds on our online BTC sportsbook.