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Jaguars vs. Bills 2023 NFL Week 5 Odds, Preview & Pick

By Jeff Stinger

European NFL fans will be spoiled for the second straight week, as the Jacksonville Jaguars pull an encore in London. This time around, the Jaguars will face the Buffalo Bills in a preview of a possible playoff showdown this season. Can the Jags get back to a winning record, or will it be the Bills who stay red hot?

Nitrobetting is ready to take your bets into the end zone this 2023 NFL season. Let’s take a closer look at the upcoming Week 5 international clash between the Jacksonville Jaguars and the Buffalo Bills.

Jaguars vs. Bills Game Information

  • When: Sunday, October 8, 2023. 9:30 AM ET
  • Where: Tottenham Hotspur Stadium, London
  • TV: NFL Network
  • Radio: WJXL AM 1010 (Jaguars) // WGR 550 SportsRadio (Bills)
  • Live Stream: NFL+
  • NFL Odds: Jaguars (+5.5) // Bills (-5.5)

Why Bet on the Jacksonville Jaguars?

Although far from unbeatable whenever they make their annual trip to the United Kingdom, the Jacksonville Jaguars were anointed kings of the NFL’s international scene in Week 4 after routing the Atlanta Falcons, 23-7. Jacksonville snapped its brief two-game skid as its offense found a bit more consistency.

Trevor Lawrence threw just seven incompletions out of his 30 pass attempts, finishing with 207 passing yards and a touchdown to Calvin Ridley, who’s been held quiet since busting back into the NFL scene in Week 1. The Jaguars did struggle to gain momentum on the ground, though, averaging just 3.3 yards on 30 carries against Atlanta.

On a more positive note, the Jags’ defense stepped up in London, sacking Desmond Ridder four times and forcing two Falcons turnovers. Jacksonville’s D has been middle of the pack through four weeks and will face one of the AFC’s most potent offenses in Buffalo. The Jaguars did hold the Chiefs to just 17 points in Week 2, so it’s more than possible that this unit can relatively contain the Bills’ assault on Sunday morning.

Why Bet on the Buffalo Bills?

It was another clinical offensive performance for the Buffalo Bills, who blasted the Miami Dolphins out of the water, 48-20, to claim seize control of first place in the AFC East from the Fins. Over the last three weeks, Buffalo has averaged a whopping 41 points per contest and their defense hasn’t slowed down either, even against a Miami offense that hung up 70 points on the Broncos in Week 3.

Josh Allen was masterful under center, going 21-of-25 for 320 passing yards and four passing TDs with no picks. Top wideout Stefon Diggs had himself a hat trick in the end zone while hauling in six of seven targets for 120 receiving yards to put the Dolphins’ offense to shame.

With an average of just 13.8 points allowed per game to their opponents, the Bills are currently ranked second in the league in that department. Their 16 sacks are also tied for the most in the NFL along with the Chargers, and this stellar stop unit should have its way against a Jacksonville offense that has yet to reach its full potential.

Jaguars vs. Bills Betting Trends

  • Jacksonville currently on a four-game road winning streak (SU/ATS), not including their London game last week as a virtual home game.
  • The Jaguars are 5-3 in the last eight games against AFC East teams (SU/ATS).
  • The totals went under in five of Jacksonville’s last seven games in general.
  • Buffalo is 9-1 in the last 10 regular-season games as favorites to win (7-3 ATS).
  • The Bills are 4-2 in its last six meetings against Jthe Jags since 2012 (3-3 ATS).
  • The totals went over in six of the last seven games between these two teams.

Jaguars vs. Bills Expert Betting Predictions

The Jaguars’ London luck should run out this weekend, as the Bills are firing on all cylinders right now and are looking more like the best team in the AFC. Chalk this up as a comfortable win by Buffalo in double-digits to easily cover the spread and even despite sacrificing a home game for this international spectacle in the fabled Tottenham Hotspur Stadium.

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*All stated odds are subject to change without prior notice.