Top MLB Betting Picks of the Week (April 11th, 2022)

By Hank Blaine • April 11, 2022

Major League Baseball heads into their first week with great matchups happening all the way to Sunday. On Tuesday, the two favorites to win the AL East clash when the Yankees host the Blue Jays. St. Louis battles Milwaukee this week and the Rays head to Chicago to take on the White Sox. See below for analysis and free MLB betting picks for six of this week’s most important matchups.

Top MLB Betting Picks of the Week (April 11th, 2022)

MLB Power Rankings: Unbeaten Rays at No. 1 following first weekend of 2022 https://t.co/KOPDNzvGe4
— CBS Sports MLB (@CBSSportsMLB) April 11, 2022

Toronto Blue Jays vs. New York Yankees

When: Tuesday, April 12th, 2022. 7:05pm ET
Where: Yankee Stadium, New York City, NY
TV: SNET, SNET-1, YES
Radio: Sportsnet 590 The FAN (Blue Jays) / WFAN 101.9 FM (Yankees)
MLB Betting Odds: TBA

Toronto lists Yusei Kikuchi as Tuesday’s starting pitcher. Kikuchi went 7-9 with a 4.41 ERA last season. He’s faced Yankee batters 54 times. NYY hits .291 versus Kikuchi. The Yankees plan on starting Nestor Cortes. In 2021, Cortes went 2-4 but he posted a very good 2.90 ERA. Both teams should have success at the plate. Give the Yankees the nod because this happens in their stadium and their bats are familiar with Kikuchi.

MLB Betting Pick: Yankees

San Diego Padres vs. San Francisco Giants

When: Wednesday, April 13th, 2022. 3:45pm ET
Where: Oracle Park, San Francisco, CA
TV: Bally Sports San Diego, MLBN, NBCS BA
Radio: Sportsnet 590 The FAN (Padres) / WFAN 101.9 FM (Giants)
MLB Betting Odds: TBA

On Wednesday, former Oakland A’s ace Sean Manaea steps to the mound for the second time in a Padre uniform. In his first start for San Diego, Manaea dominated, throwing 7 innings, giving up 0 hits, and striking out 7.

The Giants counter Manaea with one of their top pitchers, Logan Webb. Webb gave up 5 hits, struck out 3, and gave up an earned run in his first start. This should be a tight match, which means the Friars get the call because they should offer slightly better odds than the Giants.

MLB Betting Pick: Padres

St. Louis Cardinals vs. Milwaukee Brewers

When: Thursday, April 14th, 2022. 5:14pm ET
Where: American Family Field, Milwaukee, WI
TV: Bally Sports Midwest, Bally Sports Wisconsin
Radio: KMOX 1120 AM (Cardinals) / 620 AM WTMJ (Brewers)
MLB Betting Odds: TBA

Cardinals versus Brewers is one of the week’s best series. On Thursday, St. Louis starts Mike Mikolas. The St. Louis righty didn’t throw badly in his first foray to the mound. The Cardinals did struggle to beat Miami, though. But Mikolas holds the Brewers to less than a .200 batting average. Brewers starter Corbin Burnes was horrible versus the Cubs in his first start. The Cards are worth a look to pull off the upset win.

MLB Betting Pick: Cardinals

Tampa Bay Rays vs. Chicago White Sox

When: Friday, April 15th, 2022. 7:10pm ET
Where: Guaranteed Rate Field, Chicago, IL
TV: Apple TV+
Radio: WDAE 95.3 FM (Rays) / ESPN WMVP AM 1000 (White Sox)
MLB Betting Odds: TBA

Last season, Corey Kluber, who the Rays plan on sending to the mound in this, went 5-3 with a 3.83 ERA. There’s no telling if Kluber will show up with his best stuff. We do know Chicago pitcher Dylan Cease will. In his first start, Cease threw 5 innings, struck out 8, walked 3, and gave up a run. The White Sox look tough. But Chicago figures to be overplayed in this spot. The Rays should offer overlay odds, making them a nice choice.

MLB Betting Pick: Rays

Minnesota Twins vs. Boston Red Sox

When: Saturday, April 16th, 2022. 2:10pm ET
Where: Fenway Park, Boston, MA
TV: Bally Sports North, NESN
Radio: News Talk 830 WCCO (Twins) / WEEI-FM 93.7 FM (Red Sox)
MLB Betting Odds: TBA

Minnesota listed starter Bailey Ober went 3-3 with a 4.19 ERA last season. Ober should have a tough time dealing with a strong Boston batting lineup. The Red Sox, though, aren’t a lock. Tanner Houck had a decent ERA in 2021, 3.52, but he went 1-5. Still, Boston will be happy not to have to play the rival Yankees this weekend like they did opening weekend. The Red Sox get the win.

MLB Betting Pick: Red Sox

Philadelphia Phillies vs. Miami Marlins

When: Sunday, April 17th, 2022. 2:10pm ET
Where: loanDepot park, Miami, FL
TV: NBCSP, Bally Sports Florida
Radio: WIP FM 94.1 (Phillies) / WAMR-FM 710 (Marlins)
MLB Betting Odds: TBA

Phillies’ expect Zach Wheeler to take the mound on Sunday. Wheeler went 14-10 with a 2.78 ERA last season. In their first couple of games versus the Oakland Athletics, the Phillies were terrific. Philadelphia blasted the A’s 9-5 and 4-2. The bats should be there versus Miami starter Elieser Hernandez. The Phils win by at least 2 runs.

MLB Betting Pick: Phillies

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*All odds stated are subject to change without prior notice.