NC State vs. Clemson 2022 College Football Week 5 Odds, Preview & Pick

By Hank Blaine

It’s a top ten clash on Saturday in Clemson when the 5-ranked Tigers host the 10-ranked NC State Wolfpack. Clemson outlasted Wake Forest last Saturday in what will go down as a classic. The Tigers beat Wake 51-45. Clemson can’t rest this week because NC State is as formidable as it gets. Will the Tigers reestablish themselves as the top team in the conference? Or will NC State prove why so many believe they, and not Clemson, wins the ACC?

Before everything else, NitroBetting arms you with everything you need to kick things off on a positive note. Below, we provide event details, team and player statistics, and the latest NCAAF odds. More than that, we go the extra mile and share timely betting trends and predictions that help you secure the best picks. Check out for more sports betting odds and lines, exclusively at our online Bitcoin sportsbook.

NC State vs. Clemson Game Information

  • When: Saturday, October 1, 2022, 7:30 PM ET
  • Where: Memorial Stadium, Clemson, SC
  • TV: ABC
  • Radio: WRAL 101.5 FM (NC State) // WCCP 105.5 FM The Roar (Clemson)
  • Live Stream: ESPN+
  • College Footall Odds: NC State (-17) // Clemson (+17)

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Why Bet on the NC State Wolfpack?

After a tough first game against the East Carolina Pirates, NC State’s offense has rolled. The Wolfpack scored just 21 points versus the Pirates. In their second game, NC State laid 55 onto Charleston Southern. Then in their third game, the Wolfpack blasted Texas Tech 27-14. The Pack followed the win over Tech with a 41-10 beating of Connecticut.

Everything starts with quarterback Devin Leary. Leary completes over 64% of his passes. He’s thrown 8 TDs to just 2 picks. The Wolfpack averages 157 rushing yards per game and over 411 total yards each contest.

This season, NC State’s defense has played lights out. The Wolfpack gave up 20 points to East Carolina in their first game. Since then, the most any team has scored is 14. Texas Tech averages 36.8 points per. Not only that, but the Red Raiders upset Texas 37-34 in NCAAF Week 4.

Holding Tech to 14 points is big. On average, opponents score 11.8 points per game versus the Wolfpack. NC State allows less than 180 passing yards, and less than 82 rushing yards per game.

Why Bet on the Clemson Tigers?

Last season, Clemson’s offense struggled. This season, the Tigers are tearing it up. Clemson averages close to 459 yards per game and over 43 points each contest.

Tigers’ quarterback D.J. Uagielelei has already thrown for over 1,000 yards and 10 touchdowns to a single interception. Running back Will Shipley has rushed for over 350 yards and scored 7 rushing touchdowns. Clemson can beat you through the air or on the ground. Clemson averages 183.5 rushing yards and 275 passing yards each contest.

The Tigers’ defense has played well. Clemson allows 21.8 points per game from 349.8 yards per contest. Clemson defenders have already taken the ball away 5 times. Defensive tackle Ruke Orhorhoro leads the team with 2 sacks. Malcolm Greene has a pick. Opponents rush for less than 83 yards per game versus Clemson’s D.

NC State vs. Clemson Betting Trends

  • Wolfpack is 6-0 ATS in the last 6 games following an ATS loss.
  • NC State is 5-14 ATS in the last 19 road games.
  • Under is 6-1 in the last 7 meetings in Clemson.
  • Tigers are 1-5 ATS in the last 6 games in October.
  • Clemson is 2-8 ATS in the last 10 games at home.
  • Over is 3-1-1 in the Tigers’ last 5 games at home.

NC State vs. Clemson Expert Betting Predictions

Clemson almost lost their one tough matchups. Wake Forest hung 45 points onto Clemson’s defense. In the game before, Louisiana Tech scored 20. Even Furman managed 12. Clemson’s D may not be as good as football analysts believe. The Tigers offense has played well. But of Uiagalelei’s 10 touchdown passes, 5 happened versus the Demon Deacons.

NC State struggled versus East Carolina, but since then the Wolfpack have dominated. Also, East Carolina is an upper classmen heavy squad. The Wolfpack is a better team than Clemson. NC State should win this straight up. The +6.5 makes the Pack an overlay.

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*All stated odds are subject to change without prior notice.