Notre Dame vs. USC 2022 College Football Week 13 Odds, Preview & Pick

By Hank Blaine • November 25, 2022

One of college football’s most historic rivalries resumes on Saturday when the Southern California Trojans host the Notre Dame Irish. A lot will be at stake when Notre Dame and USC clash on Nov. 26. USC still has hopes of making the College Football Playoff while the Irish are angling for a traditional New Year’s Day Bowl bid. Which team in this fantastic rivalry gets it done?

Before everything else, NitroBetting arms you with everything you need to kick things off on a positive note. Below, we provide event details, team andplayer statistics, and the latest NCAAF odds. More than that, we go the extra mile and share timely betting trends and predictions that help you secure the best picks. Check out for more sports betting odds and lines, exclusively at our online Bitcoin sportsbook.

Notre Dame vs. USC Game Information

Our final game in @lacoliseum for the 2022 season! ✌️ #PackTheColi

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⌚️ 4:30 PT / 7:30 ET pic.twitter.com/udIXVLybkc
— USC Football ✌️ (@uscfb) November 23, 2022

When: Saturday, November 26, 2022, 7:30 PM ET
Where: Los Angeles Memorial Coliseum, Los Angeles, CA
TV: ABC
Radio: 88.1 FM KWVA (Notre Dame) // 1240 KEJO AM (USC)

Live Stream

WatchESPN

College Footall Odds: Notre Dame (+5.5) // USC (-5.5)

Why Bet on the Notre Dame Fighting Irish?

Early in the season, the Fighting Irish struggled on offense. In recent weeks, Notre Dame’s offense has played great football.

The Irish average over 31 points per game. Notre Dame prefers to rush the ball, averaging 192 yards on the ground each contest. Total averaged yards equals 380.4. Audric Estime leads the team with 11 touchdowns. The Irish have turned the ball over 6 times this season.

HC Marcus Freeman used to coach the Fighting Irish’s defense. Freeman takes pride in the unit and it shows. Notre Dame’s D allows 20.3 points per game from 316.8 total yards.

The Irish have 9 takeaways on the season. Isaiah Foskey has created havoc in 2022 with 9 sacks. Benjamin Morrison has 5 picks.

Why Bet on the Oregon State Beavers?

The Trojans boast one of the top offenses in the nation. Lincoln Riley’s offense averages 513 yards per game, ranking second in the nation. The Trojans rank third in points per game at 42.9.

The system flatters Heisman contender Caleb Williams. Caleb has thrown for 3,480 yards and 33 TDs. USC’s QB has tossed just 3 interceptions. Williams averages 330.8 yards per game. The Trojans rush for 182.2 each contest.

If USC has a flaw, it has to be their defense. The Trojans don’t come close to posting the stats’ that Notre Dame’s D posts. USC allows 26.3 points per game from 405 total yards.

What’s really disturbing if you’re a Trojans fan is that the defense gives up 147.2 rushing yards on average each game. One great thing about USC’s D is that it has 18 takeaways on the season, ranking first in the nation.

Notre Dame vs. USC Betting Trends

Fighting Irish are 6-1 ATS in the last 7 games on grass.
Notre Dame is 13-3 ATS in the last 16 on the road versus a team with a winning home record.
Over is 5-0 in Notre Dame’s last 5 games.
Trojans are 5-1 ATS versus a team with a winning record.
USC is 7-3 ATS in the last 10 games on grass.
Over is 5-0 in the Trojans’ lats 5 games.

Notre Dame vs. USC Expert Betting Predictions

This game should be a contrast in styles. USC is an offensive juggernaut while the Fighting Irish play excellent defense. Not only that, but the Irish are on fire. Notre Dame has won 4 straight. The most impressive victory among the 4 was beating Clemson 35-14.

But Clemson’s offense can’t touch USC’s. The Trojans run and pass the ball equally well. Notre Dame’s offense will struggle to keep up, which is why even though the Fighting Irish will make this close for a while, Williams leads the Trojans to an eventual straight up win and cover.

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Check out our latest bitcoin betting guides for the 2022 College Football season. Stay tuned for more football previews and articles and don’t forget to check out the latest NCAAF betting odds at our online Bitcoin sportsbook.

*All stated odds are subject to change without prior notice.