The most important game in the Big 12 Conference happens on Saturday when the Oklahoma State Cowboys host the Oklahoma Sooners. Heading into both teams’ final game, Oklahoma is #10 on the College Football Playoff Rankings, while Oklahoma State is #7.

Check out the College Football odds, analysis, and a free pick for Oklahoma vs. Oklahoma State. Check out for more sports betting odds and lines, exclusively at our online BTC sportsbook.

Oklahoma vs. Oklahoma State Game Information

Ready for this energy ⚡️#LetsRide I #GoPokes pic.twitter.com/tNSnF5s536

— OSU Cowboy Football (@CowboyFB) November 23, 2021

• When: Saturday, Nov. 27 at 7:30 pm ET
• Where: Boone Pickens Stadium, Stillwater, Oklahoma
• TV: ABC
• Radio: KOKC AM 1520 (Oklahoma) / 680 AM (Oklahoma State)
• Live Stream: WatchESPN
• College Football Odds: Oklahoma Sooners (+5) / Oklahoma State Cowboys (-5)

READ MORE: Alabama vs. Auburn 2021 College Football Week 13 Odds, Preview & Pick

Why Bet on the Oklahoma Sooners?

The Sooners’ offense is one of the better units in the nation. Oklahoma averages 442.2 yards per game. The Sooners score 38.9 points each contest. Oklahoma runs and passes the ball equally well. Caleb Miller is more of a run-pass quarterback, while Spencer Rattler is a drop back passer. Lincoln Riley could play both in this game. If Oklahoma wins, they march into the Big 12 Championship with a terrific 11-1 record. So expect Riley to use both of his starting quarterbacks.

Oklahoma’s defense has played well this season. Opponents average just 24.2 points per game versus Alex Grinch’s D. Opposing teams only amass 384.5 total yards per game, which isn’t bad in college football. Teams pass for more yards, 262.1, than they do rush, 122.4. The one area where Oklahoma has struggled is takeaways. The Sooners have just 8 takeaways this season.

Why Bet on the Oklahoma State Cowboys?

Year in and year out, Mike Gundy fields one of the best offenses in college football. The Oklahoma State Cowboys average 413.7 yards per game. The yardage arrives from both the passing attack, 218.0 per, and rushing game, 195.7 each contest. Oklahoma State averages 31.4 points per. The Cowboys have turned the ball over just 5 times.

The Cowboys defense is one of the best in the country. Oklahoma State allows 14.9 points per game from 261.3 total yards. The yardage allowed ranks third in the nation. The points allowed each game also ranks third. Opponents pass for just 178.6 yards each game. Opposing teams rush for just 82.6 yards per contest. If Oklahoma State is to beat Oklahoma, they will do so because of their defense.

Oklahoma vs. Oklahoma State Betting Trends

• Sooners are 4-1 ATS in the last 5 games in November.
• Oklahoma is 7-3 TS in the last 10 games as an underdog.
• Under is 6-1 in Oklahoma’s last 7 games in November.
• Cowboys are 9-0 ATS in the last 9 conference games.
• Oklahoma State is 4-0 ATS in the last 4 home games.
• Under is 4-0 in Oklahoma State’s last 4 versus a team with a winning record.

Oklahoma vs. Oklahoma State Expert Betting Predictions

If Oklahoma wins, the two will dance again in the Big 12 Conference Championship next Saturday. If the Pokes beat the Sooners, though, Oklahoma State will face Baylor in the Big 12 Conference title game. More importantly for Oklahoma State, if they win this week and then win next week, and with some luck, the Cowboys could make the College Football Playoff.

A lot would have to happen for that to occur, but it’s possible. Mike Gundy’s squad should win and cover in this matchup. The bottom line is that Oklahoma State is the better team. It’s all about defense in this game.

The Pokes field the best defense in the conference and one of the best defenses in the nation. Oklahoma showed in the loss to Baylor that when they must face a strong defense, they have trouble. Gundy’s team is primed to end Oklahoma’s season on a sour note. Expect the Pokes to step it up enough for an impressive win and cover.

Where to Bet On College Football with Bitcoin

College Football odds are available all year round here at Nitrobetting. Create a Nitrobetting account now to win tons of Bitcoin from the 2022 College Football offseason with our up-to-date NCAAF futures odds, as well as our special Bitcoin Squares and Picks contests throughout the upcoming regular season!

Check out our latest sports betting guides for the 2022 College Football season. Stay tuned for more football previews and articles, and don’t forget to check out the latest NCAAF betting odds at our online Bitcoin sportsbook.