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Panthers vs. Bills 2021 NFL Week 15 Odds, Preview and Pick

By Carlos Chacon

The Carolina Panthers and the Buffalo Bills clash Sunday in Week 15. The Panthers have a very slim chance of making the playoffs. They have to snap a three-game losing streak to get things back on track. Meanwhile, the Bills are in a more comfortable position at second place in the AFC East division. The team looks to recover from back-to-back losses and a 33-27 defeat to the Buccaneers in Week 14.

Nitrobetting provides a Panthers vs. Bills preview that covers essential game information. We cover the event’s details, team and player statistics, and the latest NFL betting odds. More than that, the team makes it a point to cover timely betting trends and predictions that help you lock in on the best picks.

Panthers vs. Bills Game Information

  • When: Sunday, December 19, 2021, 1:00 PM ET
  • Where: Highmark Stadium, Orchard Park, New York
  • TV: FOX
  • Radio: WBT 1110 AM (Panthers) / WGR 550 AM (Bills)
  • Live Stream:NFL Game Pass
  • NFL Odds: Panthers (TBA) / Bills (TBA)

READ MORE: Cowboys vs. Giants 2021 NFL Week 15 Odds, Preview and Pick

Why Bet on the Carolina Panthers?

The Panthers are eager to break a three-game losing streak. Their most recent loss happened in the hands of the Falcons. The team’s last four remaining games will happen on the road and against tougher sides, including two contests against the Buccaneers.

The Panthers allowed 27 points or more in their last three games. These are underwhelming numbers considering the team averages 21.7 opponent points (eighth) per game since Week 1. The side is known more for its defense and holds a season-high record of 177.7 passing yards per game. The team also limits opponents to 115.3 rushing yards (20th) per game. As a team, they record 293.0 opponent yards per game and are currently the second-best record in the league.

There’s not much to highlight on the offensive end of the Panthers other than the fact that the Bills present a tough challenge for the visitors. The Panthers average south of 20 points per game and have the 24th best record in the NFL this season. The side does not impress on the passing end, documenting 200.9 passing yards (26th) per game. Meanwhile, they do slightly better when it comes to rushing. The unit produces 109.7 rushing yards (18th) in 13 games.

Wide receiver DJ Moore and right cornerback A.J. Bouye is on Sunday’s questionable list due to injury.

Why Bet on the Buffalo Bills?

The Bills still have the upper hand despite losing momentum in the last two weeks. Nevertheless, they lost both games by no more than six points. We expect the side to take every opportunity to close down on the AFC East leaders, the New England Patriots.

The hosts are one of the most versatile teams today. They average 27.9 points (sixth) while allowing 17.6 points (third) per game. These numbers alone tell us that the Bills will be the aggressors.

We expect the team to utilize their passing game. They currently average 261.9 yards (eighth) per game. The team also does enough on the rushing end, recording an average of 121.0 rushing yards (15th) each game.

Defense is also a big key for the Bills. The team leads the league in opponent yards per game. They limit teams to 288.9 yards in 13 games and are currently the league-best record. The side puts up a solid passing defense. The Bills average 179.5 opponent passing yards (second) per game. Additionally, they also have enough firepower to test the Panthers’ rushing plays. The Bills average 109.4 opponent rushing yards (12th) per game.

Josh Allen’s injury is a major factor leading up to the game. The quarterback suffered a foot sprain that left him on the questionable list. He is joined by wide receiver Emmanuel Sanders with a knee injury.

Panthers vs. Bills Betting Trends

  • The Panthers are 2-2 in the last four games against the Bills (1-3 ATS).
  • The Panthers are 4-3 in the last seven road games (4-3 ATS).
  • The totals went over in four of the Panthers’ last seven games against the Bills.
  • The Bills are 3-2 in the last five games at the Highmark Stadium (2-3 ATS).
  • The Bills are 3-1 in the last four home games against the Panthers (2-2 ATS)
  • The totals went under in five of the Bills’ last ten games.

Panthers vs. Bills Expert Betting Predictions

The Panthers can hold long enough to cover the spread. However, a win requires the squad to put their best foot forward. If luck stays on their side and Josh Allen misses the game, it relieves some of the weight off their shoulders. However, a Bills team looking for a win can be difficult to contain. The hosts will enter the Highmark Stadium as favorites. Furthermore, it’s a problem for the Panthers if second-choice quarterback Mitchell Trubisky heats up.

Check out our latest sports betting guides for the 2021 NFL Regular Season. Stay tuned for more Football previews and articles and don’t forget to check out the latest Football betting odds at our online Bitcoin sportsbook.

*All odds stated are subject to change without prior notice.