Patriots vs. Bills 2021 NFL Week 13 Odds, Preview and Pick

By Hank Blaine

One of the most important games of the season takes place on NFL Monday Night Football when the New England Patriots head to Buffalo to face off against the rival Bills. Buffalo and New England are tied atop the AFC East Division. The winner of this gargantuan clash will have the inside track to a division title. Buffalo is a slight home favorite, but New England is the hotter team. Which squad prevails in NFL Week 13’s top contest?

NitroBetting assembled this Patriots vs. Bills preview for a better look at the contest. Find important event details, statistics, NFL odds, trends, and our very own expert betting predictions. Check out for more Football odds, analysis, and a free picks at our online Bitcoin sportsbook.

Patriots vs. Bills Game Information

  • When: Monday, December 6, 2021, 8:15 PM ET
  • Where: Highmark Stadium, Orchard Park, New York
  • TV: ESPN
  • Radio: 98.5 The Sports Hub (Patriots) / WGR 550 (Bills)
  • Live Stream:NFL Game Pass
  • NFL Odds: Patriots (-6.5) / Bills (+6.5)

READ MORE: 49ers vs. Seahawks 2021 NFL Week 13 Odds, Analysis and Prediction

Why Bet on the New England Patriots?

The Patriots offense has developed into one of the better units in the league. New England averages 355.3 total yards. Of the yardage, 115.3 comes via the rush. Rookie quarterback Mac Jones averages 240 passing yards per game. The Patriots score 28 points each contest. Going back to Jones, the rookie completes an exceptional 70.3% of his passes. Jones’ TD to INT ratio in the last 6 games is 11-to-3.

It was only a matter of time before Bill Belichick’s defense gelled. Now that it has, the Patriots send the top D in the league to the field. New England allows a fourth-ranked 316.7 total yards per game. Opponents pass for a paltry 200 yards against the Pats. Teams rush for 115.8 versus New England.

The Patriots top stat is in points allowed. Opponents average less than 16 points per game, ranking first in the NFL. The Pats have also forced 25 takeaways, ranking second in the league.

Why Bet on the Buffalo Bills?

Josh Allen and the Bills offense are a threat to score a touchdown every time they possess the ball. Allen averages 271 passing yards per while the team rushes for 118.3 yards each game. Buffalo scores close to 30 points on average. If the offense has a flaw, it’s turnovers. The Bills have committed 16 turnovers this season, ranking twenty-second in the NFL.Buffalo sends one of the best defenses in the league to the field. The Bills allow just 275.2 total yards per, ranking first. Opponents pass for 178.5 yards per game. Buffalo holds teams to 96.6 rushing yards each contest.

The Bills ranks second behind New England in points allowed. Buffalo gives up an avearge of 16.5 points per. Buffalo ranks third in takeaways with 23 on the season.

Patriots vs. Bills Betting Trends

  • Patriots are 6-0 ATS in their last 6.
  • New England is 4-1 ATS in their last 5 on the road.
  • Under is 5-1 in New England’s last 6 on a Monday night.
  • Bills are 4-0 in their last 4 games in December.
  • Buffalo is 3-1-1 ATS in the last 5 meetings.
  • Over is 4-1 in Buffalo’s last 5 following an ATS win.

Patriots vs. Bills Expert Betting Predictions

The Bills have a very good defense, but they’ll have an issue in this game. Buffalo starting cornerback Tre’Davious White is out for the season after suffering a knee injury in the win against the New Orleans Saints.

In 11 games, White had a pick, a forced fumble, and 27 solo tackles. He would have been counted on to cover New England’s top wide receiver, Kendrick Bourne. With White out, Buffalo will have trouble keeping Mac Jones from picking them apart. Expect Josh McDaniel to draw up plays specifically targeting White’s replacement. Also expect Bill Belichick to have a specific game plan on D that prevents Josh Allen from taking the game over. Allen has shown that at times he can struggle.

Pittsburgh upset Buffalo in the Bills’ first game of the season. The Jaguars held the Bills to 6 points in a 9-6 Buffalo loss. One of the other two losses was ugly, 41-15 agianst Indianapolis. When a defense puts Allen in tough situations, he often doesn’t respond well. Belichick will put Allen in plenty of tough situations on Monday night, making the play on the Patriots straight up.

Check out our latest sports betting guides for the 2021 NFL Regular Season. Stay tuned for more Football previews and articles and don’t forget to check out the latest Football betting odds at our online Bitcoin sportsbook.

*All odds stated are subject to change without prior notice.