The San Francisco 49ers were one win away from making their second trip to the Super Bowl in three years, but sadly came up short in the 2022 NFC Championship Game against the rivals and eventual Super Bowl Champion, Los Angeles Rams. Even though they won’t be picking until the second round, the Niners have been terrific at the NFL Draft and we’re curious as to how they’ll approach the rookie market later this month.

Nitrobetting is ready to equip its bettors with the latest news, futures odds, and special features for the duration of the 2022 NFL offseason. This time, let’s examine the best first-round prospects that the San Francisco 49ers may strongly consider picking up at the upcoming 2022 NFL Draft.

San Francisco 49ers 2022 NFL Draft Best First-Round Targets

READ MORE: Green Bay Packers 2022 NFL Draft Best First-Round Targets

Roger McCreary – Auburn (CB)

Even with Charvarius Ward joining the fray, San Francisco could still use more depth in its secondary. With the 61st-overall pick in the second round, Auburn’s Roger McCreary should still be on the board given the loaded cornerback class this year. McCreary stood out as a terrific man-to-man defender, securing a pair of interceptions and 12 passes defended in his final season as a Tiger.

Nick Cross – Maryland (S)

Another direction that the Niners could go is at safety instead of cornerback if the pool of CBs starts to dry up early. That being said, Nick Cross from Maryland is a well-rounded prospect that could fit in nicely in San Fran’s secondary. Cross is considered a top-five safety in this year’s draft class, finishing his final year for the Terps with 66 tackles, three sacks, three picks, and two forced fumbles.

Darian Kinnard – Kentucky (OT)

San Francisco’s offense has its own fair share of concerns. From the likely full-season debut of Trey Lance to the lingering rumors of a frustrated Deebo Samuel, the team sure could use a fresh body on the O-line to keep its stellar running game humming. Darian Kinnard of Kentucky comes to mind as a prospect who could fall on the Niners’ lap as a superb run-blocker from his time in Lexington. Kinnard would also make for a solid insurance policy next season should center Alex Mack decide to retire or Mike McGlinchey finding a new home as a free agent.

Updated San Francisco 49ers 2022 NFL Futures Odds

As of this writing, the 49ers are priced at (+1,400) to win Super Bowl 57. They have the seventh-best odds to win Super Bowl LVII amongst all 32 NFL teams to date and the fourth-best odds to win the NFC title at (+650) only behind perennial contenders in the Green Bay Packers (+400), Tampa Bay Buccaneers (+450), and the reigning champs, the Los Angeles Rams (+600). .

Check out our latest sports betting guides for the 2022 NFL season. Stay tuned for more football previews and articles and don’t forget to check out the latest football betting odds at our online Bitcoin sportsbook.

*All stated odds are subject to change without prior notice.