Texans vs. Bills 2021 NFL Week 4 Odds, Preview and Pick

By Carlos Chacon • September 29, 2021

Two teams heading in opposite directions meet in Orchard Park this week, as the Buffalo Bills host the Houston Texans. Josh Allen has the Bills rolling with back-to-back wins, whereas the Texans are looking more like the rebuilding franchise that they were perceived with preseason expectations after dropping their second straight game in Week 3.

NitroBetting is ready to equip its bettors with all the latest previews and odds for Week 4 of the 2021 NFL season. This time, we look at the upcoming AFC clash between the Houston Texans and the Buffalo Bills. Find out more about the teams and the key players, event information, the latest NFL odds, and of course, helpful betting trends and expert betting predictions. Don’t forget to check for the latest 2021 NFL odds at out online Bitcoin sportsbook.

Texans vs. Bills Game Information

"Buffalo is heating up and the rest of the league should be on notice." ?#GoBills | #BillsMafia
— Buffalo Bills (@BuffaloBills) September 28, 2021

When: Sunday, October 3, 2021, 1:00 PM ET
Where: Highmark Stadium, Orchard Park, New York
TV: CBS
Radio: SportsRadio 610 AM (Texans) / WGR 550 AM (Bills)
Live Stream:NFL Game Pass
NFL Odds: Texans (+16.5) / Bills (-16.5)

Why Bet on the Houston Texans?

Although the Houston Texans suffered their worst loss of the 2021 season this past Sunday when they fell 24-9 to the surging Carolina Panthers, head coach David Culley still has the Texans playing relatively well compared to other much disappointing teams in the league.

There’s obviously more work to be done with rookie quarterback Davis Mills, who made his first official NFL start in Week 3. The former Stanford standout did not turn the ball over against a fierce Panthers defense, but Mills did complete just 19 of 28 passes for 168 yards and a touchdown. The running game was also rendered non-existent, as the Texans ran for just 42 rushing yards on 16 carries as a team.

Houston’s defense is allowing over 25 points per game and will face a frightening Bills passing attack ahead. Couple that porous scoring defense with an inept offense, and it stands to reason why the Texans are overwhelming underdogs in the season’s most lopsided matchup odds-wise early in this 2021 NFL campaign.

Why Bet on the Buffalo Bills?

Were there any doubts about Josh Allen’s MVP-worthy potential this season? After a slow start, the fourth-year QB now has the Buffalo Bills back with a winning record following their dominant 43-21 victory in Week 3 against a stout Washington Football Team defense.

Allen torched Washington for 358 passing yards and four passing TDs and also found the end zone with his own two feet, giving many fantasy football managers peace of mind. Buffalo’s ground game is also getting more involved on offense, with the team rushing for 122 yards on 33 carries.

Even the Bills’ defense is tightening up, forcing three Washington turnovers and holding the Football Team to just 212 yards on offense. The Texans are indeed their weakest competition this season to date, so many people are counting on the Bills to cruise towards back-to-back convincing home wins.

Texans vs. Bills Betting Trends

The Texans are 1-4 in their last four road games, but are 4-1 against the spread during that span.
The Texans are 2-2 in their last four meetings against the Bills (SU/ATS).
The totals have gone under in three of those four matchups against Buffalo.
The Bills are 8-2 at home since the start of the previous season (7-3 ATS).
The Bills are 3-2 in their last five games against AFC North teams (2-3 ATS).
The totals have gone over in four of the Bills’ last seven home games.

Texans vs. Bills Expert Betting Predictions

While a Texans upset of the Bills is far from happening, Houston’s record against the spread has been rather encouraging. Then again, the Bills have won their last two games by over 22 points apiece, making their odds to win by more than two scoring possessions a bit more enticing rather than intimidating.

Check out our latest sports betting guides for the 2021 NFL Regular Season. Stay tuned for more Football previews and articles and don’t forget to check out the latest Football betting odds at our online Bitcoin sportsbook.

*All odds stated are subject to change without prior notice.