On Thursday, the Jaguars and Bengals kick off what promises to be a terrific NFL Week 4. Top matchups include the 2-1 Dallas Cowboys hosting the 3-0 Carolina Panthers, the Arizona Cardinals taking on the Rams in L.A., and Green Bay welcoming Big Ben and the Pittsburgh Steelers. Check out the latest 2021 NFL odds, analysis, and free picks for the top games in NFL Week 4.

Top 2021 NFL Week 4 Betting Picks

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READ MORE: Top Fantasy Waiver Wire Pickups for 2021 NFL Week 4

Thursday, Sep. 30

Jacksonville Jaguars vs. Cincinnati Bengals

• 2021 NFL Week 4 Odds: Cincinnati Bengals -7.5

The line has moved from Bengals -7 to Cincinnati -7.5. Most of the love flowing to Joe Burrow and his mates is due to the Bengals’ terrific victory over the Pittsburgh Steelers in week 3. But Steelers linebacker T.J. Ward didn’t play. The Jaguars can score. This will be closer than many believe.

NFL Week 4 Pick: Jacksonville Jaguars

Sunday, Oct. 3

Tennessee Titans vs. New York Jets

• 2021 NFL Week 4 Odds: Tennessee Titans -7.5

On paper, the Titans should dominate. But Tennessee has a tendency to play down to their competition. More importantly, Jets’ quarterback Zach Wilson should be much more careful with the ball than he has been. Not only that, but the Titans allow 28 points per. The Jets could win against the spread.

NFL Week 4 Pick: New York Jets

New York Giants vs. New Orleans Saints

• 2021 NFL Week 4 Odds: New Orleans Saints -7.5

The Giants are a bad football team. On Sunday, the G-Men face the NFL’s third-ranked defense in points allowed per, one that shut down Aaron Rodgers and the Green Bay Packers in the first week. Also, even though stats assume the Saints run a vanilla offense, Jameis Winston has become an effective quarterback who can sling it when required. New Orleans wins and covers.

NFL Week 4 Pick: New Orleans Saints

Carolina Panthers vs. Dallas Cowboys

• 2021 NFL Week 4 Odds: Dallas Cowboys -4

Panthers versus Cowboys should be a fantastic game. Carolina figures to lose both straight up and against the spread, though. Carolina is so thin at corner that they traded for Jaguars’ defensive back CJ Henderson. That’s not a good sign facing one of the top passing attacks in the league. The Cowboys are playing great on both sides of the ball. Dallas records another win and cover.

NFL Week 4 Pick: Dallas Cowboys

Kansas City Chiefs vs. Philadelphia Eagles

• 2021 NFL Week 4 Odds: Kansas City Chiefs -6.5

Most feel the Chiefs easily cover this spread. KC should, but before dumping on the Chiefs don’t forget that every team, it doesn’t matter the name of the team, runs against KC’s defense. If Philadelphia left tackle Jordan Mailata plays, Philly could surprise. They may not beat Kansas City, but they can keep this closer than the number..

NFL Week 4 Pick: Philadelphia Eagles

Seattle Seahawks vs. San Francisco 49ers

• 2021 NFL Week 4 Odds: San Francisco 49ers -3

Things aren’t going well for the Seattle Seahawks. For the second straight week, Seattle blew a big lead. This time, the Hawks were up 14-0 against the Vikings only to fall 30-14. San Francisco played well in a 1-points loss to Green Bay in their last. The 49ers should easily cover the spread.

NFL Week 4 Pick: San Francisco 49ers

Arizona Cardinals vs. Los Angeles Rams

• 2021 NFL Week 4 Odds: Los Angeles Rams -5.5

Arizona has a fantastic offense. It averages 432.3 yards and 34.3 points per. But the Cards have played and beaten Tennessee, Minnesota, and Jacksonville. The Rams are light years better than Jacksonville. They’re much better than the Titans and Vikings. The problem AZ has in this is stopping Matthews Stafford and the Rams’ offense. Even if the Cards score 34.3, there’s a good chance the Rams score 42.

NFL Week 4 Pick: Los Angeles Rams

Pittsburgh Steelers vs. Green Bay Packers

• 2021 NFL Week 4 Odds: Green Bay Packers -6.5

Pittsburgh’s biggest problem is on the offensive side of the football where they average 16 points and 53 yards rushing each game. Green Bay has a good defense. So even if T.J. Ward plays and he manages to contain Rodgers and the Packers’ offense, the Steelers won’t score enough to keep this close.

NFL Week 4 Pick: Green Bay Packers

Tampa Bay Buccaneers vs. New England Patriots

• 2021 NFL Week 4 Odds: New England Patriots -6.5

It sure looks as if Tom Brady and the Buccaneers’ offense will dominate the Patriots. Ah, but Tampa averages 56.3 rushing yards per. The reason that’s important is because New England’s defense ranks second in passing yards allowed at 159.7. If Mac Jones doesn’t beat his team, the rookie quarterback should find some success versus a Tampa D that ranks 32 nd in passing yards allowed. Pats cover.

NFL Week 4 Pick: New England Patriots

Monday, Oct. 4

Las Vegas Raiders vs. Los Angeles Chargers

• 2021 NFL Week 4 Odds: Los Angeles Chargers -3.5

On Monday night, the 3-0 Las Vegas Raiders face a major test versus a terrific Chargers squad. Las Vegas has played great so far this season. However, they showed a chink in the armor in their 31-28 overtime victory versus the Dolphins. Simply put, LAC is the more mature and solid team. The Raiders are good enough to make the playoffs. But the Bolts could blow them out.

NFL Week 4 Pick: Los Angeles Chargers

Check out our latest sports betting guides for the 2021 NFL season. Stay tuned for more Football previews and articles and don’t forget to check out the latest Football betting odds at our online Bitcoin sportsbook.

*All odds stated are subject to change without prior notice.