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Top Fantasy Waiver Wire Pickups for 2021 NFL Week 6

By Carlos Chacon

Bye weeks are upon the NFL, and the change in schedule will play another huge role in the fantasy realm. As such, we’ve come up with another weekly list of possible waiver wire acquisitions who’ll fit right into any team in need of a bye week replacement or simply another valuable stash for the long fantasy season ahead.

NitroBetting is here to bring not only the latest NFL betting news and previews but also tips and updates from the realm of fantasy football. Let’s take a closer look at the top waiver wire pickups heading into NFL Week 6 of the 2021 NFL season. Learn more about the breakout players from Week 6 who are available in most fantasy leagues, as well as the latest NFL odds with regards to several of the teams featured below.

Top 2021 NFL Week 6 Fantasy Football Picks

READ MORE: 2021 NFL Week 6 Preview, Odds and Picks


Trey Lance – San Francisco 49ers

  • Pct. Owned: 35%

All the likely available and streamable quarterbacks who produced in Week 5 will be on bye in Week 6, which includes Matt Ryan, Jameis Winston, and San Francisco’s rookie QB, Trey Lance.

Lance makes for a superb speculative pickup to stash on the bench after a relatively decent showing in his first NFL start. Although the 21-year-old out of NDSU barely completed a little over half of his passes for 192 yards and a touchdown this past Sunday, he did tote the rock 16 times for 89 rushing yards. The Niners also return to the gridiron two weeks from now with favorable matchups against the Colts and Bears, and is a must-add across all dynasty leagues if he hasn’t been drafted yet at all somehow.

Running Back

Samaje Perine – Cincinnati Bengals

  • Pct. Owned: 34.7%

Considering the injury history of Bengals starting running back Joe Mixon, Samaje Perine has become highly sought after. The former Oklahoma standout showed what he can do in Week 5 when given more touches, as Perine finished with 17 points in PPR formats with 59 rushing yards along with four receptions for 24 yards and a TD catch.

Mixon and Perine each got 11 carries this past weekend and the latter was slightly more productive that afternoon than his fellow back. Here’s hoping that Cincy gives Perine a decent timeshare with Mixon once more when the team travels up north as (-3.5) road favorites against the winless Lions.

Devontae Booker – New York Giants

  • Pct. Owned: 3.8%

Another backup RB that will be a hot commodity on the waiver wire this week is New York’s Devontae Booker. With Saquon Barkley expected to be week-to-week with an ankle sprain, the former Denver Bronco will likely assume the starting role for the G-Men given his superb showing off the bench in Week 5.

Booker had 58 all-purpose yards and two trips in the end zone against the Cowboys this past Sunday; one through the air and one on the ground. The Giants won’t be on bye until Week 10, and five full weeks of rest could be Barkley’s reality until the team returns from its off week. In turn, Booker is definitely worth a peek for deeper PPR leagues as a serviceable RB3/flex play for the next month or so.

Wide Receiver

Josh Gordon – Kansas City Chiefs

  • Pct. Owned: 24.4%

Like a roach that will never die (weed pun intended), Josh Gordon made his NFL return in Week 5 as a member of the Kansas City Chiefs. Although the often-troubled wideout caught his lone target for just 11 receiving yards on Sunday night, he’s still an explosive downfield threat that compliments Kansas City’s high-flying aerial attack very well.

Funnily enough, Gordon is owned in more leagues than our next WR pickup of the week, who deserves a fantasy roster spot even more so than KC’s wideout. But seeing how the Chiefs are quite in a flux after their lackluster showing at home against the Bills in Week 5, Gordon has massive upside as a weapon that Patrick Mahomes will utilize more often in the near future in order to change up his offense’s predictability of always leaning on Travis Kelce and Tyreek Hill to do all the heavy lifting.

Kadarius Toney – New York Giants

  • Pct. Owned: 10.7%

There’s a reason why the Giants selected Kadarius Toney with their first pick at this year’s NFL Draft. The 20th-overall pick had his breakout Game in Week 5 against Dallas, hauling in 10 catches on 13 targets for 189 receiving yards. He’s now posted back-to-back double-digit fantasy performances in PPR leagues.

Working in Toney’s favor as well is that the Giants are totally depleted on offensive options with Barkley and their top three receivers all getting banged up this past week. And while New York is a (+7) home dog versus the Rams in Week 6, that just means even more passes going Toney’s way as the G-Men are expected to rally from behind in this rather lopsided matchup.

Tight End

Hunter Henry – New England Patriots

  • Pct. Owned: 35.6%

New England’s offense continues to baffle fantasy managers, but it’s possible that a clear receiving option at tight end has been decided once and for all. Hunter Henry was a beast this past weekend, turning eight targets into six receptions for 75 yards and a score.

Injuries have hampered Henry’s productivity over the years ever since he was a Charger. But now, it appears that Bill Belichick has full confidence in the six-year veteran in the passing game. The former second-round pick from Arkansas is averaging five catches for 47.7 receiving yards over his last three games and has found the end zone in back-to-back games as well. Henry’s availability on the waiver wire this week is a different matter, though, as serviceable tight ends have been hard to come by this entire season.

Check out our latest sports betting guides for the 2021 NFL Regular Season. Stay tuned for more Football previews and articles and don’t forget to check out the latest Football betting odds at our online Bitcoin sportsbook.

*All odds stated are subject to change without prior notice.